Targeted chemoradiation for advanced head and neck cancer: Analysis of 213 patients

Superselective Neck Dissection After Chemoradiation<subtitle>Feasibility Based on Clinical and Pathologic Comparisons</subtitle>

“…RADPLAT consisted of the administration of intra-arterial cisplatin (150 mg/ m 2 ) on days 1, 8, 15, and 22 and radiation therapy (1.8-2.0 Gy/d) 5 times a week for 7 weeks. 3 Collectively, there were 239 heminecks with clinically positive nodal disease among the 177 patients in the series. Tumor sites included the oropharynx (n=81), hypopharynx (n=39), larynx (n=27), oral cavity (n=19), and other (n = 11).…”

Radiation-Induced trismus in head and neck cancer patients

“…Radiotherapy (RT) is a major treatment modality for the management of head and neck malignancies; a primary therapy for many early stage malignancies, an adjuvant therapy following surgical resection, and curative as well as palliative therapy in conjunction with concurrent chemotherapy (CT) for late stage and unresectable head and neck malignancies [5,8,9,[15][16][17]19]. A meta-analysis of 120 randomized trials and approximately 25,000 patients showed that the concomitant cisplatinbased RT/CT provided the most benefit for locoregional control and survival, both in head and neck squamous cell carcinomas and nasopharyngeal carcinomas [4] On the other hand, concomitant RT/CT has a higher level of toxicity compared to RT alone [4].…”

Professional oral health care reduces oral mucositis pain in patients treated by superselective intra-arterial chemotherapy concurrent with radiotherapy for oral cancer

“…This approach has been reported to show an 80 % complete response rate in advanced HNC [8]. RADPLAT has also been reported as effective for the control of bulky nodal disease (N2-3), with a complete response rate of 66 % [9].…”