Targeted chemoembolization of tumors with poly(2-hydroxyethyl methacrylate) particles

Abstract

Thirty-four patients suffering from various kinds of tumors, including metastasis, were treated by selective embolization with both spherical and cylindrical poly(2-hydroxyethyl methacrylate) [poly(HEMA)] particles and topical chemotherapy. Treatment of a patient with carcinoid metastases in the liver is discussed. Immediately after embolization, 5-fluorouracil, and later, doxorubicin and Lipiodol, were selectively infused into the tumorous tissue for approximately 1 week. Patient received four cycles of this infusion. Chemoembolization proceeded against the background of anticoagulant therapy using small doses of heparin or its low-molecular-weight analogue, dalteparin. This was followed by transcutaneous transhepatic portography and embolization. Finally, the tumor-feeding artery and portal vein were sealed by a hydrogel. After 1.5 months, the affected liver lobe was resected. Although 4 years from the beginning of treatment, the patient is still alive. Embolization with poly(HEMA) hydrogel particles in conjunction with an anticancer drug infusion via catheter is recommended as an efficient method of tumor treatment. The therapeutic effect has been shown to be a function of ischemia and slow local infusion of drug into the tumor, and systemic drug levels can be kept low.

Possibility of Using Embolizing Preparation Derived from Poly(2-Hydroxyethyl Methacrylate) (Poly-HEMA) for Chemoemobolization

“…It explains searching for a solution, which would allow the targeted effect of cytostatics on the damaged organ and, therefore, reduction of adverse side effects. The studies performed in this direction indicate that in some cases, at simultaneous use of cytostatic preparations and embolization of vessels, the greater effect than in the case of individual use of embolization method can be reached [1][2][3][4]. Although embolizing systems used in these works…”

Peptide-Based Nanoparticles Mimic Fibrillogenesis of Laminin in Tumor Vessels for Precise Embolization

“…From the perspective of material science, one needs to in situ prepare and position an embolus, such as natural clotting (blood gel), artificial blood gel, and SiO 2 aggregates inside the tumor’s blood vessels to block it based on its specific microenvironment. In this study, we in situ prepare the embolus through mimicking the laminin fibrillogenesis specifically in blood vessels of tumors and inhibit tumor growth.…”