Targeted cancer cell inhibition using multifunctional dendrimer-entrapped gold nanoparticles

Targeted cancer theranostics using alpha-tocopheryl succinate-conjugated multifunctional dendrimer-entrapped gold nanoparticles

“…These advantages of PAMAM dendrimers enable them to be used as an ideal multifunctional nanoplatform for both imaging and drug delivery applications. However, a thorough literature investigation reveals that there are few reports dealing with the incorporation of both imaging element and drug into a single dendrimer-based nanoplatform for cancer theranostic applications [36,40]. Not to mention that the developed nanoplatforms in the literature have not been completely investigated in terms of the in vivo performance of either cancer imaging or therapy.…”

RGD peptide-modified multifunctional dendrimer platform for drug encapsulation and targeted inhibition of cancer cells

“…The past decades have seen an increasing interest in the use of various nanoparticulate systems for therapeutics (drug and gene delivery) [1][2][3][4][5][6], diagnostics [7][8][9][10], and the combination of both therapeutics and diagnostics (theranostics) [11][12][13]. In particular, the use of nanoparticles (NPs) as a drug carrier is able to overcome some of the current drawbacks of conventional cancer ligands, imaging agents, and anticancer drugs for simultaneous targeting, imaging, and therapeutic treatment of cancer cells [23][24][25][26][27].…”

Dendrimer-entrapped gold nanoparticles modified with RGD peptide and alpha-tocopheryl succinate enable targeted theranostics of cancer cells

“…A variety of nanoplatforms, including but not limited to iron oxide nanoparticles (NPs) [1][2][3], quantum dots [4,5], carbon nanotubes [6,7], gold NPs (AuNPs) [8,9], dendrimers [10][11][12], and silica NPs [13,14] have been functionalized to have both imaging and therapeutic functionalities. The major concern to build up a theranostic nanoplatform is to render the nanoplatforms with capacity to load both imaging (e.g., contrast agents) and therapeutic (e.g., drug) elements within a single nanoparticulate system.…”

“…These characteristics of dendrimers make them an ideal platform for theranostics of cancer. However, dendrimer-based theranostic nanosystems having both imaging and therapeutic functionalities have been rarely reported [10][11][12]35]. In our previous study [12], we utilized generation 5 (G5) poly(amidoamine) (PAMAM) dendrimers as a platform to link PEGylated folic acid (FA) and PEGylated ␣-tocopheryl succinate (␣-TOS) on the dendrimer periphery and to entrap AuNPs within the dendrimer interior.…”