Targeted anticancer therapy: Overexpressed receptors and nanotechnology

Silver Nanoparticles Induce Degradation of the Endoplasmic Reticulum Stress Sensor Activating Transcription Factor-6 Leading to Activation of the NLRP-3 Inflammasome

“…7A, AgNP 15 induced formation of a pyroptosome structure (Fig. 7A, arrows) similar to that of ATP (positive control) (31), whereas the localization of ASC protein remained diffuse in control cells. The number of cells expressing pyroptosome structures was also quantified in response to 25 g/ml AgNP 15 where close to 20% of cells showed the presence of ASC pyroptosome in the experimental conditions tested (Fig.…”

Peptide-Based Cancer-Targeted DDS and Molecular Imaging

“…3,4) For cancer targeting, a desired receptor is overexpressed in tumor cells or tumor-related blood vessels but not in normal cells. 5) Many cell-surface receptors have been found in cancer cells, for example, integrin receptors as extracellular matrixadhesion molecules, 6) epidermal growth factor receptors (EGFRs) and human epidermal growth factor 2 (HER2) as tyrosine kinase receptors, 7,8) somatostatin receptors as Gprotein-coupled receptors (GPCRs), and luteinizing hormonereleasing hormone (LHRH) receptor as a hormone receptor. 9) Selective ligands binding to these receptors have been developed based on the structure of chemotherapeutic molecules, carbohydrates, peptides, and antibodies.…”

Transferrin-functionalized nanographene oxide for delivery of platinum complexes to enhance cancer-cell selectivity and apoptosis-inducing efficacy

“…[11][12][13] This contributes significantly to achieving maximum anticancer effect and significantly reducing side effects. [14][15][16] This study reports on the design of a transferrin (Tf)-conjugated NGO nanosystem, which is a specific targeting molecule for oncotherapy. [17][18][19] Tf-NGO@Pt nanoparticles exhibit good water solubility through polyethylenimine (PEI) decoration.…”