Targeted and theranostic applications for nanotechnologies in medicine

Setua, Saini; Jaggi, Meena; Yallapu, Murali M.; Chauhan, Subhash C.

doi:10.1016/b978-0-323-48063-5.00006-x

Cited by 13 publications

(8 citation statements)

References 518 publications

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“…Spleen and liver as the initial sites of the accumulation of MNPs could be targeted with such particles (Quini et al, 2017). The median size of 10-50 nm is supposed to exert optimal properties, including longer circulation time (Setua et al, 2018). However, other properties such as hydrophobic/hydrophilic features and zeta potential of the particles interfere with their biodistribution (Socoliuc et al, 2020).…”

Section: Magnetic Nanoparticles For Liver Fibrosis Theranosticsmentioning

confidence: 99%

The Potential Application of Magnetic Nanoparticles for Liver Fibrosis Theranostics

et al. 2021

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Liver fibrosis is a major cause of morbidity and mortality worldwide due to chronic liver damage and leading to cirrhosis, liver cancer, and liver failure. To date, there is no effective and specific therapy for patients with hepatic fibrosis. As a result of their various advantages such as biocompatibility, imaging contrast ability, improved tissue penetration, and superparamagnetic properties, magnetic nanoparticles have a great potential for diagnosis and therapy in various liver diseases including fibrosis. In this review, we focus on the molecular mechanisms and important factors for hepatic fibrosis and on potential magnetic nanoparticles-based therapeutics. New strategies for the diagnosis of liver fibrosis are also discussed, with a summary of the challenges and perspectives in the translational application of magnetic nanoparticles from bench to bedside.

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Section: Magnetic Nanoparticles For Liver Fibrosis Theranosticsmentioning

confidence: 99%

The Potential Application of Magnetic Nanoparticles for Liver Fibrosis Theranostics

et al. 2021

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“…Recent years have witnessed unprecedented advances in scientific research and technological applications, especially in the field of nanotechnology [ 1 , 2 , 3 ]. A recent example of how nanotechnologies can positively impact our lives is their role in fighting COVID-19 global outbreak, where mRNA vaccines have been made using a nanotechnology-assisted RNA delivery approach.…”

Section: Introductionmentioning

confidence: 99%

Transition Metal Dichalcogenides (TMDC)-Based Nanozymes for Biosensing and Therapeutic Applications

et al. 2022

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Nanozymes, a type of nanomaterial with enzyme-like properties, are a promising alternative to natural enzymes. In particular, transition metal dichalcogenides (TMDCs, with the general formula MX2, where M represents a transition metal and X is a chalcogen element)-based nanozymes have demonstrated exceptional potential in the healthcare and diagnostic sectors. TMDCs have different enzymatic properties due to their unique nano-architecture, high surface area, and semiconducting properties with tunable band gaps. Furthermore, the compatibility of TMDCs with various chemical or physical modification strategies provide a simple and scalable way to engineer and control their enzymatic activity. Here, we discuss recent advances made with TMDC-based nanozymes for biosensing and therapeutic applications. We also discuss their synthesis strategies, various enzymatic properties, current challenges, and the outlook for future developments in this field.

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“…These nanoparticles are very well known from ancient times [3]. Nowadays, AuN P s are widely used nano-carriers in targeted drug delivery systems (T DDSs) for biological and theranostic applications [4], due to their physico-chemical, optical and size tunability properties [5,6] . T DDSs are relatively new techniques for delivering drugs directly to specific sites (organ, receptor, etc...).…”

Section: Introductionmentioning

confidence: 99%

Gold nanoparticles’ concentration dependent reactivity to alendronate, memantine, and tobramycin

Eissa

Mabrouk

Ebeid

et al. 2022

Preprint

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Turkevich Gold nanoparticles are the original nanoparticles that have been modified over time. Combining nanoparticles with targeting medications such as alendronate, memantine, and tobramycin will provide additional benefits in targeting specific areas in the bone, brain, and microorganisms, respectively. The reactivity and stability of nanoparticles in the presence of various drug concentrations (micro-, nano-, and milli-levels) have been studied. The absorbance spectra of nanoparticles at λmax 520 nm were always stable with alendronate, whereas with memantine and tobramycin, the spectra were unchanged (no color change) in the nano- level over twenty minutes and red shifts (color change) occurred in the micro-level. High Resolution Transmission Electron Microscopy (HRTEM) and Dynamic light scattering (DLS) revealed that the core diameter was relatively stable in all cases, whereas the hydrodynamic diameter and zeta potential varied with drug concentration. Increasing concentration increased hydrodynamic diameter slightly with memantine (from 64.99 to 98.41 nm), dramatically with tobramycin (from 135.3 to 332.16 nm), and almost negligibly with alendronate (from 52.08 to 58.94 nm). Zeta potential, conversely, is reduced as concentration increases. Memantine had the greatest reduction in negativity, followed by tobramycin, but alendronate had a slight increase in negativity. This research would be useful for the application of gold nanoparticles in targeted drug delivery, where stability and reactivity of gold nanoparticles are critical.

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Targeted and theranostic applications for nanotechnologies in medicine

Cited by 13 publications

References 518 publications

The Potential Application of Magnetic Nanoparticles for Liver Fibrosis Theranostics

The Potential Application of Magnetic Nanoparticles for Liver Fibrosis Theranostics

Transition Metal Dichalcogenides (TMDC)-Based Nanozymes for Biosensing and Therapeutic Applications

Gold nanoparticles’ concentration dependent reactivity to alendronate, memantine, and tobramycin

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