2019
DOI: 10.2174/092986732628191025094205
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Targeted and Immune-Based Therapies for Acute Myeloid Leukemia: Inflammatory Signaling and Multiple Post-Translational Modifications

Abstract: Acute myeloid leukemia (AML) is an aggressive cancer of cells derived from the myeloid lineage. The disease is characterized by an arrest in cellular differentiation and subsequent accumulation of abnormal myeloid precursor cells in the bone marrow. The standard treatment is combination chemotherapy comprising cytarabine plus an anthracycline. However, long-term survival outcomes for adult AML patients remain unchanged the past 40 years. Without postremission treatment, most patients relapse and die of the dis… Show more

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