Targeted Adsorptive Removal of Nonsteroidal Anti-inflammatory Drugs for Water Purification Using Nanoporous Zr-Based Metal–Organic Framework Microcubes

Abstract

Chemically synthesized drugs used in the industry are associated with potential environmental risks. Herein, we report the targeted adsorption of nonsteroidal anti-inflammatory drugs, with and without a carboxylic acid group, using a water-stable Zr-based porphyrinic metal–organic framework (MOF), PCN–224. Nanoporous PCN–224 contains interaction sites for drugs and thus enables the removal of organic pollutants. The removal efficiency of NPX and IBP was 96 and 94%, but PCN–224 removed only 37% of SMX from water. The apparent difference in the adsorption efficiency of PCN–224 indicates that the carboxylic acid functional groups in drugs strongly interacted with the open metal sites of the PCN–224 Zr6 node via coordination bonding, resulting in a high adsorption capacity. This discovery provided a practical approach for the selective adsorptive removal of various other drugs with carboxylate groups.

Lewis Acidic Metal–Organic Framework Assisted Ambient Liquid Extraction Mass Spectrometry Imaging for Enhancing the Coverage of Poorly Ionizable Lipids in Brain Tissue

“…Metal–organic frameworks are a class of porous crystal materials with ordered network structures formed by the chelation of metal ions or metal clusters with organic ligands. , It has lots of unique advantages such as diverse structure, adjustable pore size, large specific surface area, easy functionalization, and good thermal stability. , The large specific surface area and flexible adjustment of pore structure of MOFs provide high adsorption capacity and more active binding sites . Functionalization can be easily achieved through presynthesis or postsynthesis methods to meet different practical demands, so MOFs play an important role in the separation field. , Currently, MOFs are mainly used to assist laser desorption/ionization in MSI applications due to its good UV absorption capability and low background peaks in LDI-MS. − However, other applications of MOFs to MSI utilizing their excellent chemical adsorptive properties are still lacking.…”