Targeted Activation of G-Protein Coupled Receptor-Mediated Ca<sup>2+</sup> Signaling Drives Enhanced Cartilage-Like Matrix Formation

McDonough, Ryan C.; Price, Christopher

doi:10.1089/ten.tea.2021.0078

Cited by 3 publications

(2 citation statements)

References 114 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The cAMP signaling pathway plays a prominent role in MSC fate decision . Chondrocytes are responsible for the homeostasis of the ECM through communication, which can be mediated by the calcium ions, , and calcium ions take part in the regulation of chondrogenesis . However, the specific mechanism of these pathways in cartilage dysplasia of NSM is still unclear and needs further research.…”

Section: Discussionmentioning

confidence: 99%

Key Genes Identified in Nonsyndromic Microtia by the Analysis of Transcriptomics and Proteomics

Chen

et al. 2022

ACS Omega

View full text Add to dashboard Cite

As one of the common birth defects worldwide, nonsyndromic microtia is a complex disease that results from interactions between environmental and genetic factors. However, the underlying causes of nonsyndromic microtia are currently not well understood. The present study determined transcriptomic and proteomic profiles of auricular cartilage tissues in 10 patients with third-degree nonsyndromic microtia and five control subjects by RNA microarray and tandem mass tag-based quantitative proteomics technology. Relative mRNA and protein abundances were compared and evaluated for their function and putative involvement in nonsyndromic microtia. A total of 3971 differentially expressed genes and 256 differentially expressed proteins were identified. Bioinformatics analysis demonstrated that some of these genes and proteins showed potential associations with nonsyndromic microtia. Thirteen proteins with the same trend at the mRNA level obtained by the integrated analysis were validated by parallel reaction monitoring analysis. Several key genes, namely, LAMB 2 , COMP , APOA 2, APOC 2, APOC 3, and A 2 M , were found to be dysregulated, which could contribute to nonsyndromic microtia. The present study is the first report on the transcriptomic and proteomic integrated analysis of nonsyndromic microtia using the same auricular cartilage sample. Additional studies are required to clarify the roles of potential key genes in nonsyndromic microtia.

show abstract

Section: Discussionmentioning

confidence: 99%

Key Genes Identified in Nonsyndromic Microtia by the Analysis of Transcriptomics and Proteomics

Chen

et al. 2022

ACS Omega

View full text Add to dashboard Cite

show abstract

“…Injuries limited to only the matrix have the potential for restoration of the matrix by chondrocyte matrix synthesis [ 38 , 66 ]. If such injuries also involve chondrocyte death, spontaneous repair is limited and results in a matrix with a changed structure [ 59 ].…”

Section: Introductionmentioning

confidence: 99%

Treatment of knee cartilage lesions in 2024: From hyaluronic acid to regenerative medicine

Brittberg

2024

J. exp. orthop.

View full text Add to dashboard Cite

Intact articular cartilage plays a vital role in joint homeostasis. Local cartilage repairs, where defects in the cartilage matrix are filled in and sealed to congruity, are therefore important treatments to restore a joint equilibrium. The base for all cartilage repairs is the cells; either chondrocytes or chondrogeneic cells from bone, synovia and fat tissue. The surgical options include bone marrow stimulation techniques alone or augmented with scaffolds, chondrogeneic cell implantations and osteochondral auto‐ or allografts. The current trend is to choose one‐stage procedures being easier to use from a regulatory point of view. This narrative review provides an overview of the current nonoperative and surgical options available for the repair of various cartilage lesions.Level of EvidenceLevel IV.

show abstract

Calcium signaling of primary chondrocytes and ATDC5 chondrogenic cells under osmotic stress and mechanical stimulation

Zhou

Han

et al. 2022

Journal of Biomechanics

View full text Add to dashboard Cite

Targeted Activation of G-Protein Coupled Receptor-Mediated Ca²⁺ Signaling Drives Enhanced Cartilage-Like Matrix Formation

Cited by 3 publications

References 114 publications

Key Genes Identified in Nonsyndromic Microtia by the Analysis of Transcriptomics and Proteomics

Key Genes Identified in Nonsyndromic Microtia by the Analysis of Transcriptomics and Proteomics

Treatment of knee cartilage lesions in 2024: From hyaluronic acid to regenerative medicine

Calcium signaling of primary chondrocytes and ATDC5 chondrogenic cells under osmotic stress and mechanical stimulation

Contact Info

Product

Resources

About

Targeted Activation of G-Protein Coupled Receptor-Mediated Ca2+ Signaling Drives Enhanced Cartilage-Like Matrix Formation

Cited by 3 publications

References 114 publications

Key Genes Identified in Nonsyndromic Microtia by the Analysis of Transcriptomics and Proteomics

Key Genes Identified in Nonsyndromic Microtia by the Analysis of Transcriptomics and Proteomics

Treatment of knee cartilage lesions in 2024: From hyaluronic acid to regenerative medicine

Calcium signaling of primary chondrocytes and ATDC5 chondrogenic cells under osmotic stress and mechanical stimulation

Contact Info

Product

Resources

About

Targeted Activation of G-Protein Coupled Receptor-Mediated Ca²⁺ Signaling Drives Enhanced Cartilage-Like Matrix Formation