Targeted 8-hydroxyquinoline fragment based small molecule drug discovery against neglected botulinum neurotoxin type F

Chauhan, Ritika; Chauhan, Vinita; Sonkar, Priyanka; Vimal, Manorama; Dhaked, Ram Kumar

doi:10.1016/j.bioorg.2019.103297

Cited by 5 publications

(3 citation statements)

References 43 publications

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“…Several works have focused on the search of 7-substituted 8HQs with inhibitory activity against BoNTs (Figure ). − In the study of Roxas-Duncan et al, compound 45a was discovered, in a virtual screening, as an interesting BoNT/A LC inhibitor. However, the toxicity of this derivative in neuroblastoma N2a cells led to the search of analogues.…”

Section: Molecular Targets Of Antimicrobial 8hqsmentioning

confidence: 96%

“…The results were promising, since these compounds promoted an increase in the survival time in both prophylactic and therapeutic treatment. In the second case, the increase of survival time ranged from 16 to 24 h . Taken together, these findings are encouraging, since they demonstrate that 8HQ derivatives have a perspective of evolution to clinical trials and human use for the treatment of botulism in the future.…”

Section: Molecular Targets Of Antimicrobial 8hqsmentioning

confidence: 99%

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Novel Antimicrobial 8-Hydroxyquinoline-Based Agents: Current Development, Structure–Activity Relationships, and Perspectives

et al. 2021

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The search for new antimicrobials is imperative due to the emergent resistance of new microorganism strains. In this context, revisiting known classes like 8-hydroxyquinolines could be an interesting strategy to discover new agents. The 8-hydroxyquinoline derivatives nitroxoline and clioquinol are used to treat microbial infections; however, these drugs are underused, being available in few countries or limited to topical use. After years of few advances, in the last two decades, the potent activity of clioquinol and nitroxoline against several targets and the privileged structure of 8-hydroxyquinoline nucleus have prompted an increased interest in the design of novel antimicrobial, anticancer, and anti-Alzheimer agents based on this class. Herein, we discuss the current development and antimicrobial structure–activity relationships of this class in the perspective of using the 8-hydroxyquinoline nucleus for the search for novel antimicrobial agents. Furthermore, the most investigated molecular targets concerning 8-hydroxyquinoline derivatives are explored in the final section.

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Section: Molecular Targets Of Antimicrobial 8hqsmentioning

confidence: 96%

Section: Molecular Targets Of Antimicrobial 8hqsmentioning

confidence: 99%

Novel Antimicrobial 8-Hydroxyquinoline-Based Agents: Current Development, Structure–Activity Relationships, and Perspectives

et al. 2021

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“…Compounds like 8-hydroxyquinoline have been explored for their potential against many BoNT subtypes. Chauhan et al [ 51 ] in their study have shown their two 8-hydroxyquinoline candidate compounds: NSC1011 and NSC1014 to have remarkable extension in survival in mice models against BoNT/F challenge. Receptor binding inhibitor molecules like aurintricarboxylic acid (ATA) provided protection against BoNT A/E challenge [ 52 ].…”

Section: Introductionmentioning

confidence: 99%

Recent Advancements and Novel Approaches Contributing to the Present Arsenal of Prophylaxis and Treatment Strategies Against Category A Bacterial Biothreat Agents

2023

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Bacterial pathogens have always been a part of the ecosystem in which we thrive. Some pathogens have caused deadly outbreaks in the past and have been exploited as an agent of threat. Natural hotspots for these biological pathogens are widely distributed throughout the world and hence they remain clinically important. Technological advancement and change in general lifestyle has driven the evolution of these pathogens into more virulent and resistant variants. There has been a growing concern over the development of multidrug-resistant bacterial strains that could be used as bioweapons. This rapid change in pathogens also propels the field of science to develop and innovate new strategies and methodologies which are superior and safer to the existing ones. Some bacterial agents like— Bacillus anthracis , Yersinia pestis, Francisella tularensis and toxins produced by strains of Clostridium botulinum , have been segregated as Category A substances as they pose imminent threat to public health with a history of life threatening and catastrophic disease. This review highlights some encouraging developments and value additions in the current plan of action for protection against these select biothreat bacterial pathogens.

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Novel 2-[(8-hydroxyquinolin-7-yl)(phenyl)methylamino]benzoic acid analogs targeting the active site of botulinum neurotoxins: designing, synthesis, and biological evaluation

Agnihotri,

Kushwah,

Bansal

et al. 2024

Med Chem Res

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Targeted 8-hydroxyquinoline fragment based small molecule drug discovery against neglected botulinum neurotoxin type F

Cited by 5 publications

References 43 publications

Novel Antimicrobial 8-Hydroxyquinoline-Based Agents: Current Development, Structure–Activity Relationships, and Perspectives

Novel Antimicrobial 8-Hydroxyquinoline-Based Agents: Current Development, Structure–Activity Relationships, and Perspectives

Recent Advancements and Novel Approaches Contributing to the Present Arsenal of Prophylaxis and Treatment Strategies Against Category A Bacterial Biothreat Agents

Novel 2-[(8-hydroxyquinolin-7-yl)(phenyl)methylamino]benzoic acid analogs targeting the active site of botulinum neurotoxins: designing, synthesis, and biological evaluation

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