Target-switchable DNA hydrogels coupled with a Bi2Sn2O7/Bi2S3 heterojunction based on in situ anion exchange for the “signal-on” photoelectrochemical detection of DNA

Li, Hongkun; Cai, Qianqian; Yan, Xiaoshi; Jie, Guifen

doi:10.1039/d1nr00573a

Cited by 31 publications

(19 citation statements)

References 32 publications

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“…In another instance, Li et al designed a photo-electrochemical biosensor using similar concepts of DNA-grafted polyacrylamide and competitive-binding-induced hydrogel collapse for selective detection of the p53 gene, a known tumor suppressor. [106]…”

Section: Supramolecular Polymer Hydrogel Sensorsmentioning

confidence: 99%

Advances in the Translation of Electrochemical Hydrogel‐Based Sensors

Shafique

Vries

Strauss

et al. 2022

Adv Healthcare Materials

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Novel biomaterials for bio‐ and chemical sensing applications have gained considerable traction in the diagnostic community with rising trends of using biocompatible and lowly cytotoxic material. Hydrogel‐based electrochemical sensors have become a promising candidate for their swellable, nano‐/microporous, and aqueous 3D structures capable of immobilizing catalytic enzymes, electroactive species, whole cells, and complex tissue models, while maintaining tunable mechanical properties in wearable and implantable applications. With advances in highly controllable fabrication and processability of these novel biomaterials, the possibility of bio‐nanocomposite hydrogel‐based electrochemical sensing presents a paradigm shift in the development of biocompatible, “smart,” and sensitive health monitoring point‐of‐care devices. Here, recent advances in electrochemical hydrogels for the detection of biomarkers in vitro, in situ, and in vivo are briefly reviewed to demonstrate their applicability in ideal conditions, in complex cellular environments, and in live animal models, respectively, to provide a comprehensive assessment of whether these biomaterials are ready for point‐of‐care translation and biointegration. Sensors based on conductive and nonconductive polymers are presented, with highlights of nano‐/microstructured electrodes that provide enhanced sensitivity and selectivity in biocompatible matrices. An outlook on current challenges that shall be addressed for the realization of truly continuous real‐time sensing platforms is also presented.

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Section: Supramolecular Polymer Hydrogel Sensorsmentioning

confidence: 99%

Advances in the Translation of Electrochemical Hydrogel‐Based Sensors

Shafique

Vries

Strauss

et al. 2022

Adv Healthcare Materials

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“…Li et al. reported a photoelectrochemical (PEC) sensor [ 74 ] based on DNA hydrogel and S 2− -sensitizing-Bi 2 Sn 2 O 7 by the anion-exchange reaction and applied it to the ultrasensitive detection of p53 gene DNA ( Fig. 4 A).…”

Section: Biological Stimuli-responsive Dna Hydrogelsmentioning

confidence: 99%

Design and application of stimuli-responsive DNA hydrogels: A review

Chen¹,

Yang

Li³

et al. 2022

Materials Today Bio

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“…In this work, DNA hydrogels encapsulating Fe 3 O 4 superparamagnetic iron oxide nanoparticles (SPIONs) are synthesized using the target aptamer as a cross-linking agent, at which time the Fe 3 O 4 SPIONs are in the aggregated state. Upon addition of the target, the [51] aptamer dissociates by binding to it, causing the DNA hydrogel to disintegrate and the released aggregated particles to disperse, resulting in a decrease in relaxation time T2, leading to quantitative detection of the signal change detected by LF-NMR. Through the flexible design of the probe, the method can provide alternative assays for clinical diagnostics, environmental monitoring and food safety testing etc.…”

Section: Dna Hydrogels In Other Biosensing Signals Dna Hydrogel-based...mentioning

confidence: 99%

“…This ensues the reversible and switchable hydrogel-to-sol or hydrogel-to-solid transitions at the macroscopic scale, which makes the hydrogels highly promising for drug delivery [31][32][33][34][35][36], controlled release [37][38][39][40][41], tissue engineering [42][43][44] and sensing applications [45][46][47]. Especially in the field of sensing, the DNA hydrogels combined with the diverse sensing platforms react with the metal ions [48,49], nucleic acids [50][51][52][53][54], proteins [55,56] and carcinogens [57], thereby converting them as changes in DNA hydrogel material properties, allowing the sensitive and specific target detection [58,59]. Therefore, the DNA hydrogels are the functional platforms to detect a wide range of stimuli under different conditions.…”

Section: Introductionmentioning

confidence: 99%

Stimuli-responsive DNA-based hydrogels for biosensing applications

Chen¹,

Wang²,

Zhang³

et al. 2022

J Nanobiotechnol

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The base sequences of DNA are endowed with the rich structural and functional information and are available for the precise construction of the 2D and 3D macro products. The hydrogels formed by DNA are biocompatible, stable, tunable and biologically versatile, thus, these have a wide range of promising applications in bioanalysis and biomedicine. In particular, the stimuli-responsive DNA hydrogels (smart DNA hydrogels), which exhibit a reversible and switchable hydrogel to sol transition under different triggers, have emerged as smart materials for sensing. Thus far, the combination of the stimuli-responsive DNA hydrogels and multiple sensing platforms is considered as biocompatible and is useful as the flexible recognition components. A review of the stimuli-responsive DNA hydrogels and their biosensing applications has been presented in this study. The synthesis methods to prepare the DNA hydrogels have been introduced. Subsequently, the current status of the stimuli-responsive DNA hydrogels in biosensing has been described. The analytical mechanisms are further elaborated by the combination of the stimuli-responsive DNA hydrogels with the optical, electrochemical, point-of-care testing (POCT) and other detection platforms. In addition, the prospects of the application of the stimuli-responsive DNA hydrogels in biosensing are presented. Graphical abstract

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Target-switchable DNA hydrogels coupled with a Bi₂Sn₂O₇/Bi₂S₃ heterojunction based on in situ anion exchange for the “signal-on” photoelectrochemical detection of DNA

Abstract: In this paper, a novel photoelectrochemical (PEC) “signal-on” biosensor based on Bi2Sn2O7/Bi2S3 heterojunction coupled with target-switchable DNA hydrogels was reported for ultrasensitive detection of P53 gene DNA. Sulfide ions are...

Cited by 31 publications

References 32 publications

Advances in the Translation of Electrochemical Hydrogel‐Based Sensors

Advances in the Translation of Electrochemical Hydrogel‐Based Sensors

Design and application of stimuli-responsive DNA hydrogels: A review

Stimuli-responsive DNA-based hydrogels for biosensing applications

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