DOI: 10.33540/1534
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Target site bioanalysis and pharmacokinetics of antileishmanial drugs

Abstract: This thesis focuses on bioanalytical method development and validation of antileishmanial drugs amphotericin B, miltefosine, and paromomycin in human plasma and human skin tissue followed by clinical target site pharmacokinetic outcomes induced by these developed bioanalytical methods. Chapter 1 provides an overview of bioanalytical quantification methods of the most relevant antileishmanial used in human pharmacokinetic studies and clinical trials. It covers (liposomal) amphotericin B, miltefosine, paromomyc… Show more

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