Target-organ damage and incident hypertension

Abstract

In the nonhypertensive population, each subclinical form of TOD independently predicts incident hypertension. In addition, the combinations of various forms of TOD are associated with stepwise increases in the risk for developing hypertension. The results suggest that asymptomatic TOD does not always exist in an intermediate stage in the cardiovascular continuum.

Brachial-Ankle Pulse Wave Velocity Predicts New-Onset Hypertension and the Modifying Effect of Blood Pressure in a Chinese Community-Based Population

“…Our finding of the relation between baPWV, as an indicator of artery stiffness, and an increased risk of hypertension or BP progression is consistent with previous studies [13][14][15][16][17][18][19][20][21][22][23]. Early in ARIC study [13], data of 6 years' follow-up among 6992 normotensive individuals aged 45-64 years revealed that arterial elasticity, measured from B-mode ultrasound of carotid artery, was associated with 15% elevated risk of hypertension per 1 SD decrease.…”

“…Adding to prior reports on the existence of association between baPWV and BP increment or incident hypertension, our study is novel in showing that baseline SBP could modify this interrelationship. It is worth noting that there was obvious interactive effect between baPWV and SBP, and a stronger predicting value of baPWV existed in individuals with optimal SBP level, in accordance with the data in normotensive participants of a Korean genome and epidemiology study [22]. One possible speculation is that in those with optimal SBP level, baPWV as a representor of other risk factor clusters may have more important role than in those with higher SBP levels; however, we have already adjusted other common covariates, and the baseline characteristics of the optimal SBP group were related to a low arteriosclerosis risk.…”

“…We also performed subgroup and interactive analysis to explore the modification effect of covariates, especially baseline SBP levels, on the relationships between baseline baPWV and BP progression and new-onset hypertension. baPWV ≥1400 m/s was adopted as the cut-off value of increased artery stiffness or arteriosclerosis as previously reported [22,30].…”

“…However, the causal relation between them is of continuous debate [10]. Early studies demonstrated that elevated BP or poorly controlled hypertension can increase artery stiffness [11,12], whereas cumulating evidence revealed that higher artery stiffness preceded hypertension and should play an important role in the pathogenesis of arterial hypertension and also the BPcontrolling process [13][14][15][16][17][18][19][20][21][22][23][24][25].…”

Subclinical left ventricular diastolic dysfunction and incident type 2 diabetes risk: the Korean Genome and Epidemiology Study

“…However, recent literatures have reported that increased LV mass and arterial stiffness are predictors of incident hypertension in both normotensive and prehypertensive individuals [16, 17]. Moreover, our previous findings demonstrated that the clustering of target organ damage types, including LV hypertrophy, LV diastolic dysfunction, carotid atherosclerosis, and arterial stiffness, substantially increases the risk of developing hypertension in the non-hypertensive population, irrespective of baseline BP category and obesity status [18]. Similar to previous reports regarding the temporal correlation between incident hypertension and preclinical types of target organ damage, Izzo et al [2] reported that the presence of target organ damage, such as LV hypertrophy and carotid atherosclerosis, is a significant predictor of new-onset T2D in a population of treated hypertensive patients.…”