Target of rapamycin (TOR) regulatesCURLY LEAF(CLF) translation in response to environmental stimuli
Yihan Dong,
Ez-Zahra Oubassou,
Elise Hoffmann
et al.
Abstract:The target of rapamycin (TOR)-Polycomb repressive complex 2 (PRC2) pathway is a crucial link that translates environmental and developmental cues into chromatin, thus reprogramming transcription. While the PRC2 methyltransferase Curly leaf (CLF) is known to be specifically involved, the underlying mechanism remains unclear. This study sheds light on how TOR fine-tunes CLF protein levels by promoting translation re-initiation mediated by eIF3h. We found that the second upstream open reading frame (uORF) located… Show more
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