Target motion management in breast cancer radiation therapy

Piruzan, Elham; Vosoughi, Naser; Mahdavi, Seied Rabi; Khalafi, Leila; Mahani, Hojjat

doi:10.2478/raon-2021-0040

Cited by 9 publications

(7 citation statements)

References 146 publications

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“…Oxygen Hydrogen Carbon Nitrogen Sulfur Sodium phosphor Chlorine Density = 1.02 g/cm 3 Weight fraction 0.527 0.106 0.332 0.03 0.002 0.001 0.001 0.001…”

Section: Methodsmentioning

confidence: 99%

“…Breast cancer is one of the most common cancers among women worldwide [1]. Early detection and diagnosis play a key role in the treatment of breast cancer [1][2][3]. Dedicated molecular breast imaging has been made possible by developments in both fields of single-photon emission tomography (SPECT) and positron emission tomography (PET).…”

Section: Introductionmentioning

confidence: 99%

“…Dedicated molecular breast imaging has been made possible by developments in both fields of single-photon emission tomography (SPECT) and positron emission tomography (PET). So far, several higher resolution, small field-ofview (FOV) cameras for planner scintimammography have been introduced and developed [2][3][4][5][6][7]. Wang et al [8] in 1997, introduced a multiple-camera vertical axis-of-rotation SPECT system to image breast cancer for patients in the prone position.…”

Section: Introductionmentioning

confidence: 99%

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Design and optimization of a breast-dedicated SPECT scanner with multi-lofthole collimation

Saed¹,

Sadremomtaz²,

Mahani³

2022

J. Inst.

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Background: the need for simultaneous high-sensitivity and high-resolution breast SPECT imaging mandates to design and optimize dedicated scanners. Therefore, this work aims to design and optimize a novel breast-dedicated SPECT system with multi-lofthole collimator. Materials and Methods: in this research, a novel breast-dedicated scanner is designed and then optimized. The scanner is equipped with a single full-ring multi-lofthole collimation long with modular NaI(Tl) detectors. The step-and-shoot data acquisition was considered with two steps. Then, an analytic optimization was conducted to balance the existing sensitivity-resolution tradeoff. To do so, several scanner geometries were investigated. The optimal configuration maximized the system sensitivity at a given system resolution. Furthermore, the scanner was also modeled within the GATE simulator. Then, detector energy resolution, septal penetration and scattering, and system sensitivity were calculated. Analytic findings were also compared with the simulated ones. Results: the results showed that high sensitivity of about 2 cps/kBq can be obtained for a diameter of lofthole 3.05 mm with a 75° opening angle. Results of GATE simulations showed clinically acceptable performance of the system offering 9% energy resolution for a point source. The septal penetration and scattering were approximately 0.5% and 0.2%, respectively, for cylindrical water phantom and tungsten as collimator material. Conclusion: the designed SPECT scanner provides promising results in terms of sensitivity and spatial resolution and therefore outperforms the traditional multi-pinhole collimation by a much higher sensitivity at a given system resolution.

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“…Oxygen Hydrogen Carbon Nitrogen Sulfur Sodium phosphor Chlorine Density = 1.02 g/cm 3 Weight fraction 0.527 0.106 0.332 0.03 0.002 0.001 0.001 0.001…”

Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Design and optimization of a breast-dedicated SPECT scanner with multi-lofthole collimation

Saed¹,

Sadremomtaz²,

Mahani³

2022

J. Inst.

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“…Hence, the DIBH is not an ideal approach for addressing the dosimetric accuracy issue caused by the chest wall motion. In addition, interfractional breast edema and positioning error can further increase the magnitude of chest wall displacement [14][15][16].…”

Section: Introductionmentioning

confidence: 99%

Comparative Study of Plan Robustness for Breast Radiotherapy: Volumetric Modulated Arc Therapy Plans with Robust Optimization versus Manual Flash Approach

Chan,

Ng,

Hung

et al. 2023

Diagnostics

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A previous study investigated robustness of manual flash (MF) and robust optimized (RO) volumetric modulated arc therapy plans for breast radiotherapy based on five patients in 2020 and indicated that the RO was more robust than the MF, although the MF is still current standard practice. The purpose of this study was to compare their plan robustness in terms of dose variation to clinical target volume (CTV) and organs at risk (OARs) based on a larger sample size. This was a retrospective study involving 34 female patients. Their plan robustness was evaluated based on measured volume/dose difference between nominal and worst scenarios (ΔV/ΔD) for each CTV and OARs parameter, with a smaller difference representing greater robustness. Paired sample t-test was used to compare their robustness values. All parameters (except CTV ΔD98%) of the RO approach had smaller ΔV/ΔD values than those of the MF. Also, the RO approach had statistically significantly smaller ΔV/ΔD values (p < 0.001–0.012) for all CTV parameters except the CTV ΔV95% and ΔD98% and heart ΔDmean. This study’s results confirm that the RO approach was more robust than the MF in general. Although both techniques were able to generate clinically acceptable plans for breast radiotherapy, the RO could potentially improve workflow efficiency due to its simpler planning process.

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“…Radiotherapy has been demonstrated to be effective for breast cancer ( 9 ). It can not only kill tumor cells but also directly promote immune-mediated tumor rejection by enhancing the total effect of tumor antigen processing and cross presentation, making tumor cells sensitive to immune recognition and attack, and increasing the immunosuppressive state of the tumor microenvironment, which promotes the recruitment, activation and action of T cells ( 10 , 11 ).…”

Section: Introductionmentioning

confidence: 99%

The effect of tumor vascular remodeling and immune microenvironment activation induced by radiotherapy: quantitative evaluation with magnetic resonance/photoacoustic dual-modality imaging

Xu,

Wu,

Gao

et al. 2023

Quant Imaging Med Surg

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Background Tumor radiotherapy combined with immunotherapy for solid tumors has been proposed, but tumor vascular structure abnormalities and immune microenvironment often affect the therapeutic effect of tumor, and multimodal imaging technology can provide more accurate and comprehensive information in tumor research. The purpose of this study was to evaluate the dynamic monitoring of tumor blood vessels and microenvironment induced by radiotherapy by magnetic resonance/photoacoustic (MR/PA) imaging, and to explore its application value in radiotherapy combined with immunotherapy. Methods The tumor-bearing mice were randomly allocated into six groups, which received different doses of radiation therapy (2 Gy ×14 or 8 Gy ×3) and anti-programmed death ligand-1 (PD-L1) antibody for two consecutive weeks. MR/PA imaging was used to noninvasively evaluate the response of tumor to different doses of radiotherapy, combined with histopathological techniques to observe the tumor vessels and microenvironment. Results The inhibitory effect of high-dose radiotherapy on tumors was significantly greater than that of low-dose radiotherapy, with the MR images revealing that the signal intensity decreased significantly (P<0.05). Compared with those in the other groups, the tumor vascular density decreased significantly (P<0.01), and the vascular maturity index increased significantly in the low-dose group (P<0.05). The PA images showed that the deoxyhemoglobin and total hemoglobin levels decreased and the SO 2 level increased after radiation treatment (P<0.05). In addition, the high-dose group had an increased number of tumor-infiltrating lymphocytes (CD4+ T and CD8+ T cells) (P<0.01, P<0.05) and natural killer cells (P<0.001) and increased PD-L1 expression in the tumors (P<0.05). The combination of radiotherapy and immunotherapy increased the survival rate of the mice (P<0.05), and a regimen of an 8 Gy dose of radiation combined with immunotherapy inhibited tumor growth and increased the survival rate of the mice to a greater degree than the 2 Gy radiation dose with immunotherapy combination (P=0.002). Conclusions Differential fractionation radiotherapy doses exert biological effects on tumor vascular and the immune microenvironment, and MR/PA can be used to evaluate tumor vascular remodeling after radiotherapy, which has certain value for the clinical applications of radiotherapy combined with immunotherapy.

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Target motion management in breast cancer radiation therapy

Cited by 9 publications

References 146 publications

Design and optimization of a breast-dedicated SPECT scanner with multi-lofthole collimation

Design and optimization of a breast-dedicated SPECT scanner with multi-lofthole collimation

Comparative Study of Plan Robustness for Breast Radiotherapy: Volumetric Modulated Arc Therapy Plans with Robust Optimization versus Manual Flash Approach

The effect of tumor vascular remodeling and immune microenvironment activation induced by radiotherapy: quantitative evaluation with magnetic resonance/photoacoustic dual-modality imaging

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