Target-Induced Aggregation of Gold Nanoparticles for Colorimetric Detection of Bisphenol A

Hwang, Sun Hee; Jeong, Sehan; Choi, Hyung Joo; Eun, Hyunmin; Jo, Min Geun; Kwon, Woo Young; Kim, Seokjoon; Kim, Yonghwan; Lee, Mi Ran; Park, Ki Soo

doi:10.1155/2019/3676384

Cited by 20 publications

(11 citation statements)

References 31 publications

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“…Binding of an analyte to the AuNPs modified with molecular bio-recognition elements (e.g., antibodies, peptides, aptamers, enzymes, etc.) induces a distinct shift in the LSPR, consequently resulting in the change of color from ruby red to blue [ 60 , 62 , 63 ]. The intensity of color is directly proportional to the concentration of an analyte and used to confirm the presence and state of the disease.…”

Section: Biological Application Of Aunpsmentioning

confidence: 99%

Multifunctional Gold Nanoparticles for Improved Diagnostic and Therapeutic Applications: A Review

et al. 2021

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The medical properties of metals have been explored for centuries in traditional medicine for the treatment of infections and diseases and still practiced to date. Platinum-based drugs are the first class of metal-based drugs to be clinically used as anticancer agents following the approval of cisplatin by the United States Food and Drug Administration (FDA) over 40 years ago. Since then, more metals with health benefits have been approved for clinical trials. Interestingly, when these metals are reduced to metallic nanoparticles, they displayed unique and novel properties that were superior to their bulk counterparts. Gold nanoparticles (AuNPs) are among the FDA-approved metallic nanoparticles and have shown great promise in a variety of roles in medicine. They were used as drug delivery, photothermal (PT), contrast, therapeutic, radiosensitizing, and gene transfection agents. Their biomedical applications are reviewed herein, covering their potential use in disease diagnosis and therapy. Some of the AuNP-based systems that are approved for clinical trials are also discussed, as well as the potential health threats of AuNPs and some strategies that can be used to improve their biocompatibility. The reviewed studies offer proof of principle that AuNP-based systems could potentially be used alone or in combination with the conventional systems to improve their efficacy.

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Section: Biological Application Of Aunpsmentioning

confidence: 99%

Multifunctional Gold Nanoparticles for Improved Diagnostic and Therapeutic Applications: A Review

et al. 2021

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“…In the presence of a proper target, the ssDNA aptamer binds to it, leaving AuNP to aggregate and change color ( Figure 1 C). One such cationic detergent, Cetrimonium bromide (CTAB), mediated AuNP aggregation and helped in the detection of the Bisphenol A (BPA) level in different daily used products where a BPA-specific aptamer played a role [ 26 ]. This helped to regulate its level to below toxicity.…”

Section: Applicationsmentioning

confidence: 99%

Identification and Engineering of Aptamers for Theranostic Application in Human Health and Disorders

Basu

Chakraborty

Pal

et al. 2021

IJMS

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An aptamer is a short sequence of synthetic oligonucleotides which bind to their cognate target, specifically while maintaining similar or higher sensitivity compared to an antibody. The in-vitro selection of an aptamer, applying a conjoining approach of chemistry and molecular biology, is referred as Systematic Evolution of Ligands by Exponential enrichment (SELEX). These initial products of SELEX are further modified chemically in an attempt to make them stable in biofluid, avoiding nuclease digestion and renal clearance. While the modification is incorporated, enough care should be taken to maintain its sensitivity and specificity. These modifications and several improvisations have widened the window frame of aptamer applications that are currently not only restricted to in-vitro systems, but have also been used in molecular imaging for disease pathology and treatment. In the food industry, it has been used as sensor for detection of different diseases and fungal infections. In this review, we have discussed a brief history of its journey, along with applications where its role as a therapeutic plus diagnostic (theranostic) tool has been demonstrated. We have also highlighted the potential aptamer-mediated strategies for molecular targeting of COVID-19. Finally, the review focused on its future prospective in immunotherapy, as well as in identification of novel biomarkers in stem cells and also in single cell proteomics (scProteomics) to study intra or inter-tumor heterogeneity at the protein level. Small size, chemical synthesis, low batch variation, cost effectiveness, long shelf life and low immunogenicity provide advantages to the aptamer over the antibody. These physical and chemical properties of aptamers render them as a strong biomedical tool for theranostic purposes over the existing ones. The significance of aptamers in human health was the key finding of this review.

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“…One of such cationic detergent, Cetrimonium bromide (CTAB) mediated AuNP aggregation helped in detection of Bisphenol A (BPA) level in different daily use products where BPA specific aptamer was used. This helps to regulate its level below toxicity (Hwang, 2019). Point of Care Test (POCT) or bed-side test is the diagnostic test which performed near the patient (Quesada-Gonzalez & Merkoci, 2018) among which Lateral Flow Assay (LFA) is considered to be very popular.…”

Section: Diagnosticsmentioning

confidence: 99%

“…The hybrid aptamer-antibody assay was superior to the aptamer-aptamer assay due to its low limit of detection (0.1-1 ng/ml). It has shown its efficiency even in human serum sample where proteases, other proteins, ions are present (detection limit >10ng/ml) which indicates its future application in clinical detection (Hwang, 2019). ALISA has been successfully used in detection of different forms of tuberculosis like tuberculous meningitis (A. , pleural tuberculosis (Kumari et al, 2019), pulmonary tuberculosis (Lavania, 2018) etc.…”

Section: Diagnosticsmentioning

confidence: 99%

Identification and Engineering of Aptamers for Theranostic Application in Human Health and Disorders

Sarkar¹,

Sharma²,

Basu³

et al. 2020

Preprint

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Aptamer is short sequence of synthetic oligonucleotides which bind to their cognate target specifically while maintaining similar or higher sensitivity as antibody. Small size, chemical synthesis, low batch variation, cost effectiveness, long shelf life and above all low immunogenicity provide advantages over antibody. The in-vitro selection of aptamer applying a conjoining approach of chemistry and molecular biology is referred as Systematic Evolution of Ligands by Exponential enrichment (SELEX). These initial products of SELEX are considered as first generation aptamers, further modified chemically in an attempt to make it stable in biofluid avoiding nuclease digestion and renal clearance. These types of aptamers are called second generation aptamers. While modification is incorporated, enough care should be taken to maintain its sensitivity and specificity. These modifications and several improvisations have widened the window frame of aptamer application that is currently not only restricted to in-vitro system, but have been used in molecular imaging for disease pathology and treatment. In food industry it is used as sensor for detection of different diseases or fungal infections. In this review we have discussed a brief history of its journey, process of synthesis, different types of modifications to improve its characters. We have also focused on its applications and highlighted its role as therapeutic plus diagnostic; theranostic tools. Finally, the review is concluded with a brief discussion on future prospective in immunotherapy, as well as in identification of novel biomarkers in stem cell, and also in single cell proteomics (scProteomics) to study intra or intertumor heterogeneity at protein level.

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Target-Induced Aggregation of Gold Nanoparticles for Colorimetric Detection of Bisphenol A

Cited by 20 publications

References 31 publications

Multifunctional Gold Nanoparticles for Improved Diagnostic and Therapeutic Applications: A Review

Multifunctional Gold Nanoparticles for Improved Diagnostic and Therapeutic Applications: A Review

Identification and Engineering of Aptamers for Theranostic Application in Human Health and Disorders

Identification and Engineering of Aptamers for Theranostic Application in Human Health and Disorders

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