Target Identification and Polypharmacology of Nutraceuticals

Dormán, György; Flachner, Beáta; Hajdú, István; András, Csaba

doi:10.1016/b978-0-12-802147-7.00021-8

Cited by 15 publications

(10 citation statements)

References 99 publications

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“…Several toxic adulterants or contaminants such as heavy metals, pesticides, mycotoxins, phytotoxicants, and abused drugs can significantly compromise the quality as well as use of nutraceuticals. Mixing of these adulterants in high amounts can lead to severe health consequences and even death [242]. For instance, pyrrolizidine alkaloids are among the most toxic alkaloids present in several plant species.…”

Section: Contaminants Compromising the Quality Of Nutraceuticalsmentioning

confidence: 99%

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Nutraceuticals: Transformation of Conventional Foods into Health Promoters/Disease Preventers and Safety Considerations

et al. 2021

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Nutraceuticals are essential food constituents that provide nutritional benefits as well as medicinal effects. The benefits of these foods are due to the presence of active compounds such as carotenoids, collagen hydrolysate, and dietary fibers. Nutraceuticals have been found to positively affect cardiovascular and immune system health and have a role in infection and cancer prevention. Nutraceuticals can be categorized into different classes based on their nature and mode of action. In this review, different classifications of nutraceuticals and their potential therapeutic activity, such as anti-cancer, antioxidant, anti-inflammatory and anti-lipid activity in disease will be reviewed. Moreover, the different mechanisms of action of these products, applications, and safety upon consumers including current trends and future prospect of nutraceuticals will be included.

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Section: Contaminants Compromising the Quality Of Nutraceuticalsmentioning

confidence: 99%

“…These alkaloids contaminate several foods and nutraceuticals and react with proteins causing abnormal mitosis, tissue necrosis, and cellular dysfunctions [243][244][245]. These are hepatotoxic and have carcinogenic and cytotoxic potentials [242].…”

Section: Contaminants Compromising the Quality Of Nutraceuticalsmentioning

confidence: 99%

Nutraceuticals: Transformation of Conventional Foods into Health Promoters/Disease Preventers and Safety Considerations

et al. 2021

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“…Results revealed their potential to support the immune system and metabolic activity of the main organs (such as liver, mammary gland, and gut) prior to and after parturition, especially when inflammatory response activate various components of the immune system and alterations in metabolism [4]. These motives have promoted the value of nutraceuticals, where complex multitarget polypharmacological mechanisms, such as activation of antioxidant defense and anti-inflammatory pathways (along with beneficial effects on cells through integrity, survival, proliferation, and differentiation), are exhibited [5].…”

Section: Introductionmentioning

confidence: 99%

Role of nutraceuticals during the transition period of dairy cows: a review

Lopreiato

Mezzetti

Cattaneo

et al. 2020

J Animal Sci Biotechnol

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The transition period of dairy cattle is characterized by a number of metabolic, endocrine, physiologic, and immune adaptations, including the occurrence of negative energy balance, hypocalcemia, liver dysfunction, overt systemic inflammatory response, and oxidative stress status. The degree and length of time during which these systems remain out of balance could render cows more susceptible to disease, poor reproductive outcomes, and less efficient for milk production and quality. Studies on both monogastrics and ruminants have reported the health benefits of nutraceuticals (e.g. probiotics, prebiotics, dietary lipids, functional peptides, phytoextracts) beyond nutritional value, interacting at different levels of the animal's physiology. From a physiological standpoint, it seems unrealistic to disregard any systemic inflammatory processes. However, an alternate approach is to modulate the inflammatory process per se and to resolve the systemic response as quickly as possible. To this aim, a growing body of literature underscores the efficacy of nutraceuticals (active compounds) during the critical phase of the transition period. Supplementation of essential fatty acids throughout a 2-month period (i.e. a month before and a month after calving) successfully attenuates the inflammatory status with a quicker resolution of phenomenon. In this context, the inflammatory and immune response scenario has been recognized to be targeted by the beneficial effect of methyl donors, such as methionine and choline, directly and indirectly modulating such response with the increase of antioxidants GSH and taurine. Indirectly by the establishment of a healthy gastrointestinal tract, yeast and yeast-based products showed to modulate the immune response, mitigating negative effects associated with parturition stress and consequent disorders. The use of phytoproducts has garnered high interest because of their wide range of actions on multiple tissue targets encompassing a series of antimicrobial, antiviral, antioxidant, immune-stimulating, rumen fermentation, and microbial modulation effects. In this review, we provide perspectives on investigations of regulating the immune responses and metabolism using several nutraceuticals in the periparturient cow.

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“…Pn was identified in cherries, blueberries, cranberries, mango, or sweet potato [26]. Mv and Pt, the least frequent anthocyanidins, are of no less importance, as they are present in important quantities in red berries, black currant, bilberries, grapes, and red wine [27]. Anthocyanidins can be further modified in versatile ways, an example being their glycosylation by attaching 1 to 3 glycosidic groups such as arabinose, glucose, xylose, galactose, and rhamnose [10].…”

Section: Chemistrymentioning

confidence: 99%

Anthocyanins as Key Phytochemicals Acting for the Prevention of Metabolic Diseases: An Overview

et al. 2022

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Anthocyanins are water-soluble pigments present in fruits and vegetables, which render them an extensive range of colors. They have a wide distribution in the human diet, are innocuous, and, based on numerous studies, have supposed preventive and therapeutical benefits against chronic affections such as inflammatory, neurological, cardiovascular, digestive disorders, diabetes, and cancer, mostly due to their antioxidant action. Despite their great potential as pharmaceutical applications, they have a rather limited use because of their rather low stability to environmental variations. Their absorption was noticed to occur best in the stomach and small intestine, but the pH fluctuation of the digestive system impacts their rapid degradation. Urine excretion and tissue distribution also occur at low rates. The aim of this review is to highlight the chemical characteristics of anthocyanins and emphasize their weaknesses regarding bioavailability. It also targets to deliver an update on the recent advances in the involvement of anthocyanins in different pathologies with a focus on in vivo, in vitro, animal, and human clinical trials.

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Target Identification and Polypharmacology of Nutraceuticals

Cited by 15 publications

References 99 publications

Nutraceuticals: Transformation of Conventional Foods into Health Promoters/Disease Preventers and Safety Considerations

Nutraceuticals: Transformation of Conventional Foods into Health Promoters/Disease Preventers and Safety Considerations

Role of nutraceuticals during the transition period of dairy cows: a review

Anthocyanins as Key Phytochemicals Acting for the Prevention of Metabolic Diseases: An Overview

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