Target hematologic values in the management of essential thrombocythemia and polycythemia vera

Hernández‐Boluda, Juan Carlos; Gómez, Montse

doi:10.1111/ejh.12381

Cited by 19 publications

(14 citation statements)

References 61 publications

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“…Thrombosis in large arteries is a major cause of mortality or can induce neurologi-cal, cardiac, and peripheral arterial disorders. (1,3,(8)(9)(10) Splenomegaly or hepatomegaly can be found in some cases that is about 15 -20%, but we didn't find in this case.…”

Section: Discussionmentioning

confidence: 74%

Diagnosis and Management of Essential Thrombocythemia in Sanjiwani Hospital Gianyar, Bali: A Case Report

Wardani¹,

Putra²,

Rena³

2018

WMJ

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Abstract.Essential thrombocythemia (ET) is a very rare disorder with 1-/100,000 population in the world. The incidence of this abnormality is still obscure in Indonesia. We report a case of ET, women of age 74 years old that came to Sanjiwani Hospital with gum bleeding. This case is confirmed based on WHO criteria of ET which are the increasing of thrombocyte of a number of increase >450 /µL 3, proliferation of megakaryocyte cell on bone marrow biopsy, also not meeting any other WHO criteria for also not meeting any other WHO criteria for BCR-ABL1 + CML, Polycythemia Vera, Chronic Myeloid Leukemia, Myelodysplastic Syndrome, or other myeloid neoplasm diseases. Management of this case is based on risk adapted treatment algorithm considering three major risk factors for thrombosis (history of thrombosis, JAK2/MPL mutations, and advanced age). This case is categorized as high risk patient for thrombosis, so that treated with antiplatelet aggregation (aspilets) and anagrelide after hydroxyurea clinically unresponsive. Keywords: Essential Thrombocythemia, Thrombosis, Haemorrhage Abstrak

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Section: Discussionmentioning

confidence: 74%

Diagnosis and Management of Essential Thrombocythemia in Sanjiwani Hospital Gianyar, Bali: A Case Report

Wardani¹,

Putra²,

Rena³

2018

WMJ

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“…Por otro lado, nuestro paciente tuvo el diagnóstico de policitemia vera, enfermedad crónica mieloproliferativa caracterizada por una excesiva producción de eritrocitos y, en un 50% de los casos, de leucocitos y plaquetas [16] . Esta enfermedad incrementa el riesgo de eventos trombóticos y hemorrágicos, siendo los predictores mayores de trombosis el tener más de 60 años e historia previa de trombosis, mientras que para eventos hemorrágicos lo es tener un recuento plaquetario mayor de 1 500 x 10 9 /L [17] . Por eso, actualmente se recomienda un hematocrito objetivo < 45% a fin de evitar las complicaciones relacionadas a la enfermedad [18] .…”

Section: Discussionunclassified

Implante de válvula aórtica transcatéter transapical: un procedimiento novedoso en el norte peruano

Zamora-Rodríguez

León-Burgos

Yucra-Lazo³

et al. 2018

Acta Med Peru

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Severe symptomatic aortic stenosis secondary to degenerative calcification may be a real therapeutic challenge if the patient does not undergo an aortic valve replacement. Transapical transcatheter aortic valve replacement is a valid therapeutic option for these cases. We present the case of a 78-year old male with the following past and current medical history: high blood pressure, chronic kidney disease (stage IIIa), heavy tobacco smoking, use of a permanent pacemaker, peripheral arterial disease, and polycythemia vera. When assessed, the patient had had class III heart failure (NYHA classification) for one year. Transthoracic ultrasonography showed severe calcification of the aortic cusps, a 44.7% left ventricular ejection fraction, and a 0.58 cm 2 (0.31 cm 2 /m 2 ) valve surface area. Angiography showed moderate coronary heart disease, and angiotomography showed severe calcification of the aortic valve ('porcelain aorta'). Since this patient was considered at high-risk, a transapical transcatheter aortic valve replacement was performed (Braille Biomedical N° 30 bioprosthetic valve), and the ultrasonography controls showed satisfactory results. This case is the first procedure of its kind performed in Northern Peru.

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“…[11][12][13] Therefore, prognostic systems to classify patients into risk categories are critical because they should receive myelosuppressive therapy if classified as high risk. However, if patients are deemed as having low risk for thrombosis, myelosuppressive therapy can be avoided.…”

Section: Discussionmentioning

confidence: 99%

Application of prognostic score IPSET-thrombosis in patients with essential thrombocythemia of a Brazilian public service

Navarro

Trufelli

Bonito

et al. 2016

Rev. Assoc. Med. Bras.

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Target hematologic values in the management of essential thrombocythemia and polycythemia vera

Abstract: Treatment of essential thrombocythemia (ET) and polycythemia vera (PV) is aimed at preventing vascular complications, which are the main cause of morbidity and mortality in these diseases.

Cited by 19 publications

References 61 publications

Diagnosis and Management of Essential Thrombocythemia in Sanjiwani Hospital Gianyar, Bali: A Case Report

Diagnosis and Management of Essential Thrombocythemia in Sanjiwani Hospital Gianyar, Bali: A Case Report

Implante de válvula aórtica transcatéter transapical: un procedimiento novedoso en el norte peruano

Application of prognostic score IPSET-thrombosis in patients with essential thrombocythemia of a Brazilian public service

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