Target Design of Multinary Metal–Organic Frameworks for Near-Infrared Imaging and Chemodynamic Therapy

A small-molecule Fenton reagent for self-augmented chemodynamic therapy by intelligently regulating intracellular acidosis

“…Chemodynamic therapy (CDT), an emerging cancer therapy strategy, has garnered significant attention in recent years. 1–4 CDT relies on the Fenton (Fenton-like) reaction to catalyze the generation of hydroxyl radicals (˙OH) from less-reactive hydrogen peroxide (H 2 O 2 ). 5–9 These highly toxic ˙OH species can effectively oxidize and disrupt cellular macromolecules, such as lipids, DNA, and proteins, and could damage the intracellular reducing system represented by glutathione (GSH) and glutathione peroxidase 4 (GPX4).…”