Target based chemotherapeutic advancement of ruthenium complexes

A Novel Copper(II) Indenoisoquinoline Complex Inhibits Topoisomerase I, Induces G2 Phase Arrest, and Autophagy in Three Adenocarcinomas

“…ferrocen/ferroquine ( 43 , 64 )], ruthenium [e.g. indenoisoquinoline ( 55 ) and various complexes ( 65 , 66 )], or platin [e.g. cisplatin ( 67 )], and demonstrate the interest of these organometallic compounds in cancerology.…”

A fundamental role of the solvent polarity and remote substitution of the 2-(4-R-phenyl)-1H-imidazo[4,5-f][1,10]phenanthroline framework in controlling the ground- and excited-state properties of Re(i) chromophores [ReCl(CO)3(R-C6H4-imphen)]

“…1–20 Possessing the 1,10-phenanthroline unit with strong abilities to bind transition metals, imidazo[4,5- f ][1,10]phenanthrolines have also become very popular ligands for controlling the photophysical and antiproliferative behaviour of transition metal complexes. They have been combined with numerous transition metal ions including Cu( i ), 21–25 Cu( ii ), 26–28 Ru( ii ), 29–40 and Ir( iii ). 41–46 The vast majority of these coordination compounds have potential uses in anticancer therapy, 26–28,31,34–37,39–46 bioimaging, 32,47 the conversion of solar energy, 22,29 organic light-emitting diodes, 21,23,48–50 photoredox catalysis, 38,51,52 and luminescence sensing.…”

Pyrene-based fluorescent Ru(ii)-arene complexes for significant biological applications: catalytic potential, DNA/protein binding, two photon cell imaging andin vitrocytotoxicity

“…The contribution of transition metal ion chemistry towards cancer therapy started with the introduction of cisplatin in the treatment of cancers of the ovary, lungs, testicles, bladder, and head neck area about 40 years ago. 1 After the initial success of platinum-based metallodrugs, it has been found that there are several drawbacks to this class of complexes as well which need to be taken care of additionally. Among them, the reduced aqueous solubility of the complexes, poor selectivity towards cancer cells, associated toxicity towards healthy cells and resistance towards platinum drugs are prominent.…”