TARC in allergic disease

Sugawara, Naoto; Yamashita, Tetsuji; Ote, Y.; Miura, Michi; Terada, Nobuhisa; Kurosawa, Motohiro

doi:10.1034/j.1398-9995.2002.1n3503.x

Cited by 36 publications

(38 citation statements)

References 3 publications

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“…Elevated levels of TARC [21] and MDC [21,27] were also found in the serum of atopic dermatitis (AD) patients compared with controls. In addition, serum TARC and MDC levels correlated with the clinical and laboratory markers for AD severity [17,21,28]. These results further substantiate that these Th2 chemokines play important roles in the pathogenesis of allergic diseases.…”

Section: Discussionsupporting

confidence: 64%

“…This inflammatory marker also showed positive correlation with plasma total IgE concentration. Two other groups have observed similar findings in serum [17,18] and induced sputum [18] from adult asthmatics. The aim of this study was to investigate whether plasma TARC and MDC concentrations would be useful inflammatory markers in evaluating the disease severity of asthmatic exacerbation in children.…”

supporting

confidence: 61%

“…Plasma TARC concentration also correlated with plasma levels of total and cat-specific IgE antibodies. SUGAWARA et al [17] also reported recently in a small study that plasma TARC levels were elevated in patients with asthma. However, the authors did not study the relationship between TARC and atopy-related traits or lung function parameters.…”

Section: Discussionmentioning

confidence: 94%

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Plasma TARC concentration may be a useful marker for asthmatic exacerbation in children

Leung¹,

Wong²,

Lam³

et al. 2003

Eur Respir J

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Recent studies suggested the T-helper cells type-2 lymphocytes-specific thymus and activation-regulated chemokine (TARC) and monocyte-derived chemokine (MDC) are useful inflammatory markers for chronic asthma. However, their roles in assessing the severity of acute asthma are unknown. This study aims to evaluate the serial changes of plasma TARC and MDC concentrations in children with asthmatic exacerbation.All patients with acute asthma were treated with systemic corticosteroid for 5 days. The severity of asthmatic exacerbation was classified according to the Global Initiative for Asthma guidelines. Plasma TARC and MDC concentrations were measured by sandwich enzyme immunoassays.Sixteen children, with a median (interquartile range) age of 9.3 (7.2-10.6) yrs and asthmatic exacerbation, were recruited. Plasma TARC concentration showed inverse correlation with peak expiratory flow rate at presentation. The median plasma TARC concentration was highest during the acute attacks (46 pg?mL -1 ) as compared to those levels at 1 (31 pg?mL -1 ) and 5 weeks (32 pg?mL -1 ) following treatment. The median plasma MDC level similarly decreased from 698 pg?mL -1 at baseline to 261 pg?mL -1 1 week later, but increased back to 574 pg?mL -1 at 5 weeks. These results suggest that plasma T-helper cells type-2 lymphocytes-specific thymus and activation-regulated chemokine but not monocyte-derived chemokine concentration may be a useful inflammatory marker in assessing asthmatic exacerbation in children. Eur Respir J 2003; 21: 616-620.

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Section: Discussionsupporting

confidence: 64%

supporting

confidence: 61%

Section: Discussionmentioning

confidence: 94%

See 1 more Smart Citation

Plasma TARC concentration may be a useful marker for asthmatic exacerbation in children

Leung¹,

Wong²,

Lam³

et al. 2003

Eur Respir J

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show abstract

“…Several studies have reported that both plasma concentrations of TARC and expression of its receptor, CCR4, on peripheral blood CD4C cells were increased in patients with atopic dermatitis, suggesting that elevated plasma TARC may reflect disease activity in atopic dermatitis (20)(21)(22). Furthermore, prevalence of CCR4C cells among peripheral blood cells correlated positively with serum IgE in patients with atopic dermatitis (20), linking the pathogenesis of atopic dermatitis to Th2 dominance. However, the present study showed the discordance between plasma concentrations of TARC and the percentage of CCR4-expressing cells among peripheral blood CD4C cells in hyperthyroid patients with Graves' disease.…”

Section: Discussionmentioning

confidence: 93%

Changes in expression of T-helper (Th) 1- and Th2-associated chemokine receptors on peripheral blood lymphocytes and plasma concentrations of their ligands, interferon-inducible protein-10 and thymus and activation-regulated chemokine, after antithyroid drug administration in hyperthyroid patients with Graves’ disease

Inukai

Momobayashi²,

Sugawara³

et al. 2007

eur j endocrinol

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Objective: Although Graves' disease is considered an autoantibody-mediated, T-helper 2 (Th2)-dominant disease, Th1-dominance may prevail in its initial phase. We longitudinally investigated Th1/Th2 balance in untreated hyperthyroid patients with Graves' disease after treatment of methimazole (MMI), an antithyroid drug. Design: University clinic outpatients were studied prospectively. Patients: Subjects included 23 untreated hyperthyroid patients with Graves' disease and 17 agematched control subjects. Methods: Before and after treatment, we measured Th1-and Th2-associated chemokine receptors (CXCR)3 and CCR4, on peripheral blood lymphocytes using flow cytometry, as well as plasma concentrations of their ligands, interferon-inducible protein (IP)-10 and thymus and activationregulated chemokine (TARC). Results: The percentage of CXCR3-expressing cells among CD4C T lymphocytes and plasma IP-10 was significantly higher in hyperthyroid Graves' disease patients than in controls. At 12 and 24 weeks after initiation of MMI, percentage of CXCR3-expressing CD4 C T lymphocytes had decreased significantly, while the percentage of CCR4-expressing CD4 C T lymphocytes had increased significantly at 24 weeks. The CXCR3/CCR4 ratio had decreased significantly at 24 weeks. Plasma concentrations of IP-10 had decreased significantly at 12 and 24 weeks. Plasma concentrations of TARC also had decreased significantly at 24 weeks. Conclusions: In hyperthyroid patients with Graves' disease in the active phase, Th1 cells rather than Th2 cells predominated among peripheral blood lymphocytes. After initiation of MMI, an ongoing transition from Th1 to Th2 dominance occurred. 156 623-630 European Journal of Endocrinology

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“…There are plenty of studies suggesting a role for CCL11, CCL17, CCL18 and CCL22 in allergic disease [101][102][103][104][105][106][107][108][109][110]. These Th2-associated chemokines are predominantly induced by IL-4 and IL-13, but production of CCL18 is considerably enhanced in synergy with IL-10 [50][51][52]111].…”

Section: Th2-associated Chemokinesmentioning

confidence: 99%

Immunological interactions between mother and child during pregnancy in relation to the development of allergic diseases in the offspring

Abelius¹

2014

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TARC in allergic disease

Cited by 36 publications

References 3 publications

Plasma TARC concentration may be a useful marker for asthmatic exacerbation in children

Plasma TARC concentration may be a useful marker for asthmatic exacerbation in children

Immunological interactions between mother and child during pregnancy in relation to the development of allergic diseases in the offspring

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