Taraxacin, a New Guaianolide from Taraxacum wallichii

Abstract

A new guaianolide, taraxacin (1), and a known sesquiterpene ketolactone (2) have been isolated from an ethyl acetate-soluble part of a methanolic extract of Taraxacum wallichii. The structure of 1 was established using NMR, MS, and X-ray crystallographic methods. The (13)C NMR data of 2 is also being reported for the first time.

Anti-inflammatory activity of Taraxacum officinale

“…Some plants of the genus Taraxacum, known as dandelion, have long been used in folk medicine to treat hepatic disorders and some women's diseases, such as breast and uterus cancers, and as lactating, choleretic, diuretic, and anti-inflammatory remedies (Ahmad et al, 2000;Kisiel and Barszcz, 2000). Pharmacological activities of Taraxacum plants, especially Taraxacum officinale F. Weber ex Wiggers (Asteraceae), have been in part evaluated so far (Schutz et al, 2006).…”

Eudesmanolides from Taraxacum mongolicum and their inhibitory effects on the production of nitric oxide

“…Some plants of the genus Taraxacum, known as dandelion, have long been used in folk medicine to treat hepatic disorders and some women's diseases, such as breast and uterus cancers, and as lactating, choleretic, diuretic, and anti-inflammatory remedies (Ahmad et al, 2000;Kisiel and Barszcz, 2000). Especially Taraxacum officinale was assessed to contain acute antiinflammatory activity by showing its protective effect against cholecystokinin-induced acute pancreatitis in rats (Seo et al, 2005).…”

Difference in in vitro response and esculin content in two populations of Taraxacum officinale Weber

“…Whole plant extracts possess choleretic, diuretic, anti-inflammatory and -carcinogenic activities (Ahmad et al 2000;Choi et al 2002;Yun et al 2002;IIu and Kitts 2003). Dried Taraxacum leaves and roots are available as herbal tea.…”