TaqIB polymorphism in the CETP gene modulates the impact of HC/LF diet on the HDL profile in healthy Chinese young adults

Du, Juan; Fang, Ding Zhi; Lin, Jen‐Der; Xiao, Li; Zhou, Xue; Shigdar, Sarah; Duan, Wei

doi:10.1016/j.jnutbio.2009.09.009

Cited by 15 publications

(26 citation statements)

References 40 publications

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“…Previous studies by the present authors have found that polymorphisms in the key enzymes and lipoproteins involved in lipid metabolism, such as TaqIB polymorphism of the cholesterol ester transfer protein (CETP) gene (16) and polymorphism of sterol regulatory element-binding protein (SREBP) genes (Zhang et al, accepted by "Applied Physiology, Nutrition and Metabolism"), may modify the impact of an HC/LF diet on the lipid profile. Therefore, this study sought to test the hypothesis that LPL polymorphisms of Hind III and Ser447Stop affect changes in serum lipid levels in response to an HC/LF diet.…”

Section: Introductionmentioning

confidence: 81%

Effects of lipoprotein lipase gene variations, a high-carbohydrate low-fat diet, and gender on serum lipid profiles in healthy Chinese Han youth

Huang

Gong

Lin

et al. 2011

BST

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Section: Introductionmentioning

confidence: 81%

Effects of lipoprotein lipase gene variations, a high-carbohydrate low-fat diet, and gender on serum lipid profiles in healthy Chinese Han youth

Huang

Gong

Lin

et al. 2011

BST

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“…A total of 209 University students were screened and 60 who met the above criteria were enrolled in the study. Baseline characteristics of these subjects have been reported in our previous publications [11,12]. All subjects appeared healthy, as judged by the medical questionnaire and a physical examination.…”

Section: Methodsmentioning

confidence: 99%

“…However, little is known of the interaction between these 3 LEPR polymorphisms and HC/LF induced lipid and insulin changes. Previous studies from our lab found that polymorphisms in the key enzymes and lipoproteins that are involved in lipid metabolism [11,12] may modify the impact of a HC/LF diet on lipid profiles and insulin levels. Therefore, this study sought to test the hypothesis that LEPR polymorphisms affect changes in serum lipid profiles and insulin levels in response to a HC/LF diet.…”

Section: Introductionmentioning

confidence: 99%

High-Carbohydrate/Low-Fat Diet-Induced Gender-Specific Serum Lipid Profile Changes Are Associated with <b><i>LEPR</i></b> Polymorphisms in Chinese Youth

Tang

Zhang²,

Li³

et al. 2017

Ann Nutr Metab

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Background/Aims: The study aimed to investigate the interactions of genetic variants in the leptin receptor (LEPR) gene with lipid profile changes following a high-carbohydrate/low-fat (HC/LF) diet in a Chinese Han population. Methods: Fifty-six healthy young subjects were given washout diets, followed by HC/LF diets consisting of 15% fat and 70% carbohydrate for 6 days. Serum lipid profiles and insulin levels before and after HC/LF diets were analyzed. Results: Statistically elevated high-density lipoprotein cholesterol (HDL-C), apolipoprotein A-1 (apoA-I), and insulin levels were only observed in the GG genotype of LEPR Lys109Arg but not in the A carriers after HC/LF diet. When gender was taken into account, significantly increased HDL-C, apoA-I, and insulin levels were found in women with the GG genotype. Moreover, lower low-density lipoprotein cholesterol (LDL-C) and higher insulin levels were only observed in subjects with the GG genotype of LEPR Gln223Arg, while higher HDL-C and apoA-I were only found in the A allele carriers. Additionally, the lower LDL-C and body mass index (BMI), and higher HDL-C and insulin levels were only observed in subjects with the GG genotype of LEPR Lys656Asn. Conclusions:LEPR polymorphisms contribute to the heterogeneities in BMI, LDL-C, and HDL-C responsiveness that are induced by a HC/LF diet in healthy young Chinese adults.

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“…While dietary intervention has become an effective method of primordial prevention on dyslipidemia [23], the HC/LF diet was found to have different effects on plasma lipids in different subjects [19,24]. The mechanism of the discrepancy has not been elucidated yet.…”

Section: Resultsmentioning

confidence: 99%

Associations of Lipoprotein Lipase Gene rs326 with Changes of Lipid Profiles after a High-Carbohydrate and Low-Fat Diet in Healthy Chinese Han Youth

Zhu

Lin

Wang

et al. 2014

IJERPH

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To investigate the effects of a high-carbohydrate and low-fat (HC/LF) diet on plasma lipids and apolipoproteins (Apos) of healthy Chinese Han youth with different genotypes of lipoprotein lipase gene (LPL) rs326, 56 subjects were given a washout diet of 30.1% fat and 54.1% carbohydrate for seven days, followed by the HC/LF diet of 13.8% fat and 70.1% carbohydrate for six days, with no total energy restriction. Plasma glucose, triglyceride (TG), total cholesterol (TC), high density lipoprotein cholesterol (HDL-C), low density lipoprotein cholesterol (LDL-C), Apo B-100 and Apo A-I were analyzed at baseline and before and after the HC/LF diet. The results show that, when compared with before the HC/LF diet, only the male G carriers experienced increased HDL-C (p = 0.008) and Apo A-I (p = 0.005) after the HC/LF diet. Decreased TC in both males and females and increased TG in females were found regardless of the genotype after the HC/LF diet. LDL-C decreased in all the subjects although the decrease was not significant in the female G carriers. These results demonstrate that the G allele of LPL rs326 associates with the elevated levels of HDL-C and Apo A-I after the HC/LF diet in males of the healthy Chinese Han Youth.

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TaqIB polymorphism in the CETP gene modulates the impact of HC/LF diet on the HDL profile in healthy Chinese young adults

Cited by 15 publications

References 40 publications

Effects of lipoprotein lipase gene variations, a high-carbohydrate low-fat diet, and gender on serum lipid profiles in healthy Chinese Han youth

Effects of lipoprotein lipase gene variations, a high-carbohydrate low-fat diet, and gender on serum lipid profiles in healthy Chinese Han youth

High-Carbohydrate/Low-Fat Diet-Induced Gender-Specific Serum Lipid Profile Changes Are Associated with <b><i>LEPR</i></b> Polymorphisms in Chinese Youth

Associations of Lipoprotein Lipase Gene rs326 with Changes of Lipid Profiles after a High-Carbohydrate and Low-Fat Diet in Healthy Chinese Han Youth

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