TaqIB and severity of coronary artery disease in the Turkish population: a pilot study

Kaman, Dilara; İlhan, Nevin; Akbulut, Mehmet

doi:10.17305/bjbms.2015.157

Cited by 13 publications

(17 citation statements)

References 29 publications

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“…Our previous preliminary study on the relationships between polymorphisms in CETP and apo AI genes and parameters of lipid metabolism were performed in a relatively small group of subjects [40, 41]. Data of the present study are in agreement with previous reports indicating that the B2 allele is related to decreased CETP mass and activity, and increased HDL cholesterol concentrations and B1B1 carriers show the lowest and B2B2 carriers the highest HDL cholesterol concentrations [42, 43]. B2B2 genotype has been reported to be a protective factor against development of myocardial infarction, and B1B1 homozygotes are likely to have higher risk of CVD [44].…”

Section: Discussionsupporting

confidence: 91%

Impact of variants in CETP and apo AI genes on serum HDL cholesterol levels in men and women from the Polish population

Włodarczyk

Wrzosek

Jabłonowska-Lietz

2016

aoms

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IntroductionPolymorphisms in the cholesterol ester transfer protein (CETP) gene and apolipoprotein AI (apo AI) gene are identified as the most common genetic factors influencing high-density lipoprotein cholesterol (HDL cholesterol) levels. Low HDL cholesterol is an important risk factor for cardiovascular disease. We investigated the effect of the TaqIB polymorphism of the CETP gene and the 75G/A polymorphism of the apo AI gene on the HDL cholesterol concentration in a sample of Polish adults.Material and methodsA total of 621 subjects, 414 women and 207 men, were included in this study. Lipid levels were measured using standard protocols, and apolipoprotein AI was determined by immunoturbidimetric assay. CETP and apo AI genotyping was performed using a restriction fragment length polymorphism based method.ResultsSignificantly lower HDL cholesterol concentrations were found in B1B1 homozygotes than in carriers of the B2 allele of the TaqIB polymorphism in the CETP gene among both men and women. In GG homozygotes of the 75G/A polymorphism in the apo AI gene lower HDL cholesterol levels were observed, but the difference did not reach statistical significance. A statistically significant association of low HDL cholesterol (< 25th percentile) with CETP genotypes was found in women (p < 0.0001) and in men (p = 0.0368).ConclusionsThese data demonstrate a significant impact of the TaqIB polymorphism in the CETP gene on HDL cholesterol levels in the studied Polish population, while the effect of the 75G/A polymorphism in the apo AI gene appears not to be significant.

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Section: Discussionsupporting

confidence: 91%

Impact of variants in CETP and apo AI genes on serum HDL cholesterol levels in men and women from the Polish population

Włodarczyk

Wrzosek

Jabłonowska-Lietz

2016

aoms

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“…The study selection process is detailed in Figure 1 . Through a comprehensive retrieval and evaluation, 45 studies from 44 papers with 20,866 cases and 21,298 controls met the inclusion criteria to assess the association between the CETP TaqIB polymorphism and the composite ischemic CVD [ 23 , 24 , 25 , 26 , 27 , 28 , 29 , 30 , 31 , 32 , 33 , 34 , 35 , 36 , 37 , 38 , 39 , 40 , 41 , 42 , 43 , 44 , 45 , 46 , 47 , 48 , 49 , 50 , 51 , 52 , 53 , 54 , 55 , 56 , 57 , 58 , 59 , 60 , 61 , 62 , 63 , 64 , 65 ]. The selected study characteristics and data are listed in Table 1 .…”

Section: Resultsmentioning

confidence: 99%

“…Among these studies, 28 involved CAD [ 23 , 24 , 25 , 26 , 27 , 28 , 29 , 30 , 31 , 32 , 34 , 35 , 36 , 37 , 38 , 39 , 44 , 46 , 47 , 50 , 52 , 53 , 54 , 55 , 59 , 60 , 61 , 66 ], three involved IS [ 63 , 64 , 65 ], and 14 involved MI [ 33 , 40 , 41 , 42 , 43 , 45 , 48 , 49 , 51 , 56 , 57 , 58 , 62 ]. In addition, there were 26 studies on Caucasians [ 23 , 24 , 25 , 27 , 30 , 38 , 39 , 40 , 41 , 42 , 43 ...…”

Section: Resultsmentioning

confidence: 99%

“…In addition, there were 26 studies on Caucasians [ 23 , 24 , 25 , 27 , 30 , 38 , 39 , 40 , 41 , 42 , 43 , 44 , 45 , 47 , 48 , 50 , 51 , 53 , 56 , 57 , 58 , 60 , 62 , 63 , 64 ] and 19 studies on Asians [ 26 , 28 , 29 , 31 , 32 , 33 , 34 , 35 , 36 , 37 , 46 , 49 , 52 , 54 , 55 , 59 , 61 , 65 , 66 ]. Controls of 23 studies were hospital-based [ 23 , 24 , 25 , 26 , 27 , 28 , 29 , 30 , 31 , 32 , 33 ,…”

Section: Resultsmentioning

confidence: 99%

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Associations of Cholesteryl Ester Transfer Protein TaqIB Polymorphism with the Composite Ischemic Cardiovascular Disease Risk and HDL-C Concentrations: A Meta-Analysis

Guo

Yao

Ding

et al. 2016

IJERPH

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Background: Previous studies have evaluated the associations between the cholesteryl ester transfer protein (CETP) TaqIB polymorphism (rs708272), the risk of developing composite ischemic cardiovascular disease (CVD) and the concentration of high-density lipoprotein cholesterol (HDL-C), but results remain controversial. The objective of this study was to investigate whether a relationship exists between these factors. Methods: We conducted a meta-analysis of available studies to clarify the associations of the CETP TaqIB polymorphism with HDL-C concentration and the composite ischemic CVD risk in both Asians and Caucasians. All statistical analyses were done with Stata 12.0. Results: Through utilization of the Cochrane Library, Embase, PubMed, Web of Science, Springer, China Science and Technology Journal Database, China National Knowledge Infrastructure, Google Scholar, and Baidu Library, a total of 45 studies from 44 papers with 20,866 cases and 21,298 controls were combined showing a significant association between the CETP TaqIB variant and composite ischemic CVD risk. Carriers of allele TaqIB-B1 were found to have a higher risk of composite ischemic CVD than non-carriers: OR = 1.15, 95% CI = 1.09–1.21, p < 0.001. Meanwhile, 28 studies with 23,959 subjects were included in the association between the CETP TaqIB polymorphism and the concentration of HDL-C. Results suggested that carriers of the B1B1 genotype had lower concentrations of HDL-C than those of the B2B2 genotype: SMD = 0.50, 95% CI = 0.36–0.65, p < 0.001. Conclusions: The synthesis of available evidence demonstrates that the CETP TaqIB polymorphism protects against composite ischemic CVD risk and is associated with a higher HDL-C concentration in both Asians and Caucasians.

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“…Several CETP gene variants such as TaqIB (rs708272) and I405V (rs5882) are associated with reduced CETP mass and HDL cholesterol (HDL-C) [ 12 , 13 ]. Both TaqIB and I405V variants are the most widely studied and were found to be associated with CAD [ 5 , 14 , 15 ], left main CAD [ 16 ] and longevity [ 17 , 18 ].…”

Section: Introductionmentioning

confidence: 99%

Biomarkers and Gene Polymorphisms in Members of Long- and Short-lived Families: A Longevity Study

Kolovou

Diakoumakou

Papazafiropoulou

et al. 2018

TOCMJ

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Background:The influence of biomarkers in human lifespan has been investigated but with no clear results yet.Materials and methods:Lipids, Uric Acid (UA), Adiponectin (ADIPOQ), Insulin-like Growth Factor (IGF-1), cholesteryl ester transfer protein (CETP) and angiotensin-converting enzyme (ACE) proteins, as well as CETP, ADIPOQ, insulin-like growth factor binding protein-3 (IGFBP3) and ACE-gene polymorphisms were evaluated in 149 Greek individuals. The Long-Lived Families (LON) (n=84) comprised of 3 generations: long-lived aged ≥90 years (P), offspring (FL1) and their grandchildren (FL2), while the Short-Lived Families (EAD) (n=65) where both parents died <75 years, comprised of 2 generations: middle-aged (FD1) and children (FD2).Results:Serum CETP and IGF-1 levels were lower, whereas AdipoQ concentrations were higher in P compared with FL1 and FL2 members (CETP: p = 0.03 for both comparisons; IGF-1 p < 0.001 for both comparisons and ADIPOQ: p = 0.001 and p = 0.004, respectively). Furthermore, serum triglycerides, UA and glucose concentrations were higher in FD1 compared with FD2 subjects (p=0.001, 0.02 and ≤0.001, respectively). In FD2 and FL2, CETP levels were lower in individuals with B2B2 compared with B1B1 genotype (p=0.007). Additionally, ACE concentrations were higher in individuals with DD compared with II genotype in both Families (p=0.001). After adjustment for age and gender, CETP levels were lower in P and FL2 individuals with B2B2 compared with the B1B1 genotype (p=0.004 and 0.007, respectively).Conclusion:Increase serum TGs, UA and GL concentrations were higher in the middle-aged individuals compared with their children in families independently of their lifespan. The serum adiponectin concentration was the highest in the oldest old individuals implying beneficial influence on lifespan. Independently of family’s lifespan history, the youngest individuals with CETPB2B2 genotype, compared with individuals with CETPB1B1 genotypes, had lower serum CETP concentrations. The knowledge of the unfavourable gene(s)influencing human lifespan may be helpful in encouraging individuals to follow healthier lifestyle habits and better control their high-risk biomarkers.

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TaqIB and severity of coronary artery disease in the Turkish population: a pilot study

Cited by 13 publications

References 29 publications

Impact of variants in CETP and apo AI genes on serum HDL cholesterol levels in men and women from the Polish population

Impact of variants in CETP and apo AI genes on serum HDL cholesterol levels in men and women from the Polish population

Associations of Cholesteryl Ester Transfer Protein TaqIB Polymorphism with the Composite Ischemic Cardiovascular Disease Risk and HDL-C Concentrations: A Meta-Analysis

Biomarkers and Gene Polymorphisms in Members of Long- and Short-lived Families: A Longevity Study

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