TAPPing into PIPs: A new reporter reveals the origin of plasma membrane PI(3,4)P2

Abstract

The membrane lipid phosphatidylinositol-3,4-bisphosphate (PI(3,4)P2) is an important signaling effector, controlling both anabolic pathways and membrane trafficking. In this issue, Goulden et al. (2019. J. Cell Biol. https://doi.org/10.1083/jcb.201809026) report a new PI(3,4)P2 probe and show that plasma membrane PI(3,4)P2 is a product of PI(3,4,5)P3 dephosphorylation.