2001
DOI: 10.1128/iai.69.7.4417-4423.2001
|View full text |Cite
|
Sign up to set email alerts
|

Tapeworm Infection Reduces Epithelial Ion Transport Abnormalities in Murine Dextran Sulfate Sodium-Induced Colitis

Abstract: The rat tapeworm Hymenolepis diminuta was used to test the hypothesis that helminth infection could modulate murine colitis. Mice were infected with five H. diminuta cysticercoids, and colitis was evoked via free access to 4% (wt/vol) dextran sulfate sodium (DSS)-containing drinking water for 5 days. BALB/c mice were either infected with H. diminuta and 7 days later exposed to DSS (prophylactic strategy) or started on DSS and infected with H. diminuta 48 h later (treatment strategy). Naive and H. diminuta-only… Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
2
1
1

Citation Types

2
57
0

Year Published

2004
2004
2015
2015

Publication Types

Select...
7
2

Relationship

3
6

Authors

Journals

citations
Cited by 101 publications
(61 citation statements)
references
References 31 publications
2
57
0
Order By: Relevance
“…In support for no role for Th2 cytokines in protection, worm infection of mice deficient in both IL-4 and IL-13 were refractory to DSS-induced colitis. These findings that a schistosome-induced Th2 response was not protective in this model are consistent with work investigating the effect of another helminth, Hymenolepis diminuta on colitis, which although inducing a robust Th2 response, also did not reduce DSS-induced tissue damage (43). However, other gastrointestinal parasitic worms may induce a regulatory type 2 response that can suppress colon inflammation in different models of colitis.…”
Section: Discussionsupporting
confidence: 90%
“…In support for no role for Th2 cytokines in protection, worm infection of mice deficient in both IL-4 and IL-13 were refractory to DSS-induced colitis. These findings that a schistosome-induced Th2 response was not protective in this model are consistent with work investigating the effect of another helminth, Hymenolepis diminuta on colitis, which although inducing a robust Th2 response, also did not reduce DSS-induced tissue damage (43). However, other gastrointestinal parasitic worms may induce a regulatory type 2 response that can suppress colon inflammation in different models of colitis.…”
Section: Discussionsupporting
confidence: 90%
“…However, when using biological organisms, the situation is likely to be more complicated that this. We previously showed that infection with H. diminuta alleviated the electrophysiological abnormalities that characterize murine DSSinduced colitis (7). Using DNBS to evoke what is considered a Th1-driven colitis (24), the present study shows that H. diminuta infection in a prophylactic regimen almost abolished the colitis, as assessed by clinical parameters, histological assessment, and biochemical markers (i.e., MPO).…”
Section: Discussionsupporting
confidence: 62%
“…It is intuitive to think that this increase in Th2 cytokines will also have the benefit of protecting the host from an unrelated Th1-type disease, such as Crohn's disease, a major form of inflammatory bowel disease (IBD) 3 characterized as having a Th1 profile (6). Previous studies from our laboratory have shown that infection with the tapeworm parasite, Hymenolepis diminuta, given both prophylactically and as a treatment, improved the abnormalities in colonic epithelial ion transport that accompany dextran sodium sulfate (DSS)-induced murine colitis (7). Other studies showed that infection with parasitic helminths can reduce the Th1 response to an unrelated infection (8,9) and have confirmed an anticolitic effect of infection with parasitic helminths (principally nematodes and Schistosoma mansoni) in murine model systems (10 -12).…”
mentioning
confidence: 99%
“…This increase in eosinophils in DSS-induced colitis may explain, at least partially, the finding that infection with H. diminuta alleviated the ion transport abnormalities but not the histopathology in this model of colitis. 39 However, colitis in oxazolone and oxazoloneϩ anti-IL-5 AB-treated mice were similar. Thus, while colonic eosinophilia is characteristic of this model of colitis, these cells may play only a small role in the disease such that the normal variation between mice in their response to oxazolone is large enough to mask any role of eosinophils that could potentially be revealed by neutralization of IL-5.…”
Section: Il-5 Andmentioning
confidence: 95%