TAp63 contributes to sexual dimorphism in POMC neuron functions and energy homeostasis

Wang, C; He, Yi; Xu, Peng; Y, ang; Saito, Kazuki; Xia, Yunlong; Yan, Xiang; A, Hinton Jr; C, Yan; Ding, Hua

doi:10.1530/ey.15.15.12

Cited by 2 publications

(3 citation statements)

References 38 publications

(45 reference statements)

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“…Table 1 gives the benchmark of our FeFETs and FeCaps. Chou et al 37 demonstrated the largest 2Pr value, but due to a lower BDS value, it did not achieve the highest I ON /I OFF ratio and MW value. In contrast, Kim et al 36 showed the largest BDS with a higher I ON /I OFF ratio, but due to lower polarization, it did not achieve MW > 2 V. In our work, using surface morphology and stress engineering, with large a polarization and a high BDS value, we achieved the highest I ON /I OFF ratio, a large MW, a low SS, and a good nonlinearity of conductance modulation in the HZO/IGZO-based FeFET.…”

Section: Acs Appliedmentioning

confidence: 88%

Stress-Memorized HZO for High-Performance Ferroelectric Field-Effect Memtransistor

Tsai

Fang

Wang

et al. 2022

ACS Appl. Electron. Mater.

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A ferroelectric field-effect transistor (FeFET), capable of logic and memory functionalities in a single device, is a promising three-terminal memtransistor that enables high-performance in-memory computing for non Von Neumann architectures. Among all HfO2-based ferroelectric materials, HfZrO2 (HZO) has attracted the most attention due to the low process temperature of ≤500 °C; however, it has relatively weak polarization. Many prior works claimed that the way to improve HZO-based FeFET characteristics is to enhance HZO ferroelectric properties, while they did not account for the fundamental compromise on dielectric breakdown strength (BDS), transistor ON/OFF current (I ON/I OFF) ratio, and memory window (MW) due to the enhanced polarization. In this work, we propose an approach for controlling the ferroelectric orthorhombic phase (O phase) and the corresponding polarization in optimal value by engineering both the surface morphology and stress of HZO layer by a thermal expansion mismatch with a TiN/W stacked capping layer, to improve the BDS, I ON/I OFF ratio, and MW. Through electrode surface optimization and stress memorization we achieved an 18% HZO ferroelectricity increase with a high BDS value of ≥4.8 MV/cm. Our optimized FeFET shows good electrical characteristics and supports operation in an identical pulse programming (IPP) mode, showing good potentiation and depression nonlinearity (−0.84 and −2.04) with an asymmetry factor of 1.2. A simulation based on the proposed FeFET array demonstrates the high potential of application in an artificial neural network (ANN).

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Section: Acs Appliedmentioning

confidence: 88%

Stress-Memorized HZO for High-Performance Ferroelectric Field-Effect Memtransistor

Tsai

Fang

Wang

et al. 2022

ACS Appl. Electron. Mater.

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“…This extremely significant difference (p < 0.0001) is the result of the anti-adhesive membrane on the surface of organ, which is similar to our previous work. [30] Both the liver and kidney are ruptured during the peeling test, and it is impossible to record the data (Figure 4e). Obviously, the adhesive energy of IFA hydrogel is greater than the cohesion of the liver or kidney.…”

Section: Wet-adhesive Diversificationmentioning

confidence: 99%

“…As shown in Figure 6f, urea is a strong hydrogen bond acceptor and donor, which can serve as a hydrogen bond breaker; [35] while, ionic solution (PBS) can shield electrostatic effects to a certain extent. [30] In depth, reduced L-Glutathione (GSH) can easily cut disulfide bonds at the interface (Figure 6g).…”

Section: Controllable Adhesionmentioning

confidence: 99%

Ferried Albumin‐Inspired Bioadhesive With Dynamic Interfacial Bonds for Emergency Rescue

Chen,

Li,

et al. 2024

Adv Healthcare Materials

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Emergency prehospital wound closure and hemorrhage control are the first priorities for life‐saving. A majority bioadhesives form bonds with tissues through irreversible cross‐linking, and the remobilization of misalignment may cause severe secondary damage to tissues. Therefore, developing an adhesive that can quickly and tolerably adhere to traumatized dynamic tissue or organ surfaces in emergency situations is a major challenge. Inspiring by the structure of human serum albumin (HSA), a branched polymer with multitentacled sulfhydryl is synthesized, then an instant and fault‐tolerant tough wet‐tissue adhesion (IFA) hydrogel is prepared. The adhesive application time is just 5 s (interfacial toughness of ∼580 J/m2) and favorable tissue‐adhesion is maintained after 10 cycles. IFA hydrogel remains unchangeable adhesive performance after one month of storage based on the internal oxidation‐reduction mechanism. It not only can efficiently seal various organs, but also achieves effective hemostasis in models of the rat femoral artery and rabbit‐ear artery. This work also proposes an effective strategy for controllable adhesion, which enables the production of asymmetric adhesives with on‐demand detachment. Importantly, IFA hydrogel has sound antioxidation, antibacterial property, hemocompatibility, and cytocompatibility. Hence, the HSA‐inspired bioadhesive can emerge as a promising first‐aid supply for human‐machine interface‐based health management and non‐invasive wound closure.This article is protected by copyright. All rights reserved

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TAp63 contributes to sexual dimorphism in POMC neuron functions and energy homeostasis

Cited by 2 publications

References 38 publications

Stress-Memorized HZO for High-Performance Ferroelectric Field-Effect Memtransistor

Stress-Memorized HZO for High-Performance Ferroelectric Field-Effect Memtransistor

Ferried Albumin‐Inspired Bioadhesive With Dynamic Interfacial Bonds for Emergency Rescue

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