TAp63 contributes to sexual dimorphism in POMC neuron functions and energy homeostasis

Abstract

Sexual dimorphism exists in energy balance, but the underlying mechanisms remain unclear. Here we show that the female mice have more pro-opiomelanocortin (POMC) neurons in the arcuate nucleus of hypothalamus than males, and female POMC neurons display higher neural activities, compared to male counterparts. Strikingly, deletion of the transcription factor, TAp63, in POMC neurons confers "male-like" diet-induced obesity (DIO) in female mice associated with decreased POMC neural activities; but the same deletion does not affect male mice. Our results indicate that TAp63 in female POMC neurons contributes to the enhanced POMC neuron functions and resistance to obesity in females. Thus, TAp63 in POMC neurons is one key molecular driver for the sexual dimorphism in energy homeostasis.

Stress-Memorized HZO for High-Performance Ferroelectric Field-Effect Memtransistor

“…Table 1 gives the benchmark of our FeFETs and FeCaps. Chou et al 37 demonstrated the largest 2Pr value, but due to a lower BDS value, it did not achieve the highest I ON /I OFF ratio and MW value. In contrast, Kim et al 36 showed the largest BDS with a higher I ON /I OFF ratio, but due to lower polarization, it did not achieve MW > 2 V. In our work, using surface morphology and stress engineering, with large a polarization and a high BDS value, we achieved the highest I ON /I OFF ratio, a large MW, a low SS, and a good nonlinearity of conductance modulation in the HZO/IGZO-based FeFET.…”