TAP1 and TAP2 polymorphisms associated with ankylosing spondylitis in genetically homogenous Chinese Han population

Feng, Min; Yin, Bo; Shen, Tong; Ma, Qing; Liu, Lidong; Zheng, Jiewei; Zhao, Yulin; Qian, Kun; Liu, Dazhuang

doi:10.1016/j.humimm.2009.01.028

Cited by 21 publications

(15 citation statements)

References 23 publications

(26 reference statements)

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“…Several studies have shown the association of TAP genes with various multifactorial diseases, such as rheumatoid arthritis (RA) in different populations [6 -9], ankylosing spondylitis in a Chinese Han population [10], diabetes mellitus [11], and viral infections such as dengue fever [12] and hepatitis B viral infection [13]. Thus, our study aimed to investigate the influence of TAP polymorphism in HIV-TB coinfections using amplification refractory mutation system (ARMS)-polymerase chain reaction (PCR).…”

Section: Introductionmentioning

confidence: 99%

Association of TAP 1 and 2 gene polymorphisms with human immunodeficiency virus–tuberculosis co-infection

et al. 2011

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Section: Introductionmentioning

confidence: 99%

Association of TAP 1 and 2 gene polymorphisms with human immunodeficiency virus–tuberculosis co-infection

et al. 2011

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“…Furthermore, Miao et al (2013) reported that the IL2RA rs3118470 SNP may constitute a genetic marker of AA risk in a Chinese population. One of the TAP1 SNPs (rs1135216) investigated in the present study has previously been associated with increased risk of ankylosing spondylitis (Feng et al, 2009). Thus, we expected that polymorphisms in this gene might be related to AA susceptibility and symptoms.…”

Section: Discussionmentioning

confidence: 71%

“…Thus, TAP genes represent possible susceptibility factors for some autoimmune diseases (Vinasco et al, 1998). Polymorphisms in such genes have been associated with various diseases, such as tuberculosis (Wang et al, 2012), ankylosing spondylitis (Feng et al, 2009), leprosy (Shinde et al, 2013), idiopathic bronchiectasis (Doğru et al, 2007), and cystic fibrosis (Ozbaş-Gerçeker et al, 2002). However, no study has investigated the association between TAP1 sequence variants and AA.…”

Section: Introductionmentioning

confidence: 99%

Association between TAP1 gene polymorphisms and alopecia areata in a Korean population

Hk¹,

H²,

Bl³

et al. 2015

Genet. Mol. Res.

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ABSTRACT. The transporter 1 ATP-binding cassette sub-family B (MDR/ TAP) gene (TAP1) is located in the major histocompatibility complex class 18821 TAP1 polymorphisms and alopecia areata ©FUNPEC-RP www.funpecrp.com.br Genetics and Molecular Research 14 (4): 18820-18827 (2015) II region, and forms a heterodimer that plays a key role in endogenous antigen presentation pathways. Investigation of polymorphisms identified in these loci has revealed an association with several autoimmune disorders. Alopecia areata (AA) is a common autoimmune disease resulting from T cell-induced damage to hair follicles. The present study documents for the first time a comparison between the allelic and genotypic frequencies of TAP1 single nucleotide polymorphisms (SNPs) in patients with AA and those of a control group, using a direct sequencing method. Our results suggest an association between a promoter SNP (rs2071480) and susceptibility to this disease.

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“…Polymorphisms of TAP genes have been associated with various diseases such as tuberculosis (Wang et al, 2012), ankylosing spondylitis (Feng et al, 2009), leprosy (Shinde et al, 2013), idiopathic bronchiectasis (Dogru et al, 2007), cystic fibrosis (Ozbas-Gerceker et al, 2002) and also with the risk of occurence of several malignant tumors including colon cancer (Yang et al, 2005), cervical carcinoma (Mehta et al, 2007) and esophageal carcinoma (Cao et al, 2005). To the best of our knowledge there has been no study on the association of TAP gene polymorphisms with hematological malignancies.…”

Section: Association Of Tap1 and Tap2 Gene Polymorphisms With Hematolmentioning

confidence: 99%

Association of TAP1 and TAP2 Gene Polymorphisms with Hematological Malignancies

Özbas‐Gerçeker

Bozman²,

Gezici³

et al. 2013

Asian Pacific Journal of Cancer Prevention

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Transporter associated with antigen presenting (TAP) 1 and TAP2 genes are localized in the major histocompatability complex (MHC) class II region and form a heterodimer playing a key role in endogenous pathways for antigen presentation. Defects of these genes have been reported to be common in different types of cancer. Polymorphisms identified in these loci have also been investigated and reported to be associated with several autoimmune disorders, viral infections and neoplasms. In the present study, for the first time, the allele and genotype frequencies of TAP1-333, TAP2-565, TAP2-651 and TAP2-665 were determined in patients with hematological malignancies (HM) using a PCR-RFLP method and compared with the frequencies in the control group. Our results suggested an association of TAP1-333 polymorphism with multiple myeloma-MM and TAP2-565 polymorphism with chronic lymphoid leukemia-CLL. In addition, it could be concluded that the TAP2-665 GG genotype might be a risk factor for all types of hematological malignancies included in this study.

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TAP1 and TAP2 polymorphisms associated with ankylosing spondylitis in genetically homogenous Chinese Han population

Cited by 21 publications

References 23 publications

Association of TAP 1 and 2 gene polymorphisms with human immunodeficiency virus–tuberculosis co-infection

Association of TAP 1 and 2 gene polymorphisms with human immunodeficiency virus–tuberculosis co-infection

Association between TAP1 gene polymorphisms and alopecia areata in a Korean population

Association of TAP1 and TAP2 Gene Polymorphisms with Hematological Malignancies

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