TaOx decorated perfluorocarbon nanodroplets as oxygen reservoirs to overcome tumor hypoxia and enhance cancer radiotherapy

Song, Guohe; Ji, Chenghong; Liang, Chao; Song, Xuejiao; Yi, Xuan; Dong, Ziliang; Yang, Kai; Liu, Zhuang

doi:10.1016/j.biomaterials.2016.10.020

Cited by 203 publications

(169 citation statements)

References 35 publications

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“…[72] With PFC loading, PEG-Bi 2 Se 3 @PFC was able to act oxygen reservoir and gradually release oxygen, offering improved radio-sensitization effect at the in vitro level. [241] After saturating PFC with oxygen, TaOx@PFC could improve tumor oxygenation and greatly enhanced in vivo RT treatment. As the result, such oxygen loaded nanoparticles could remarkably and synergistically enhance RT by the high-Z radio-sensitization of bismuth, photothermal effect, and enhanced tumor oxygenation.…”

Section: Increase Of Tumor Oxygenation By Oxygen Deliverymentioning

confidence: 99%

“…Thus, our group further developed nano-droplets of PFC stabilized by albumin as an oxygen shuttle for tumor-specific delivery of oxygen with the help of tumor-focused low-intensity ultrasound (Figure 13). 2017, 29,1700996 Hemoglobin-based oxygen carrier [230,237] Perfluorocarbon (PFC) emulsions; BSA coated PFC emulsion; PFC loaded hollow Bi 2 Se 3 ; TaOx decorated with PFC nanodroplets [238][239][240][241] Mild hyperthermia [39,71,73] Increase tumor oxygenation by catalysis of endogenic H 2 O 2 MnO 2 nanopartilces; MnO 2 nanosheets@ upconversion; Au@MnO 2 core-shell [242][243][244][245][246][247] Polymer micelles encapsulating catalase and TaOx@catalase [248][249][250] Hypoxia-specific therapy accompany hypoxia-specific cytotoxicity of tirapazamine [58,251] X-ray controlled NO releasing [56] Radioprotection to reduce side effects Free radical scavengers CeO 2 nanoparticles [252,253] Melanin nanoparticles [254,255] MoS 2 dots [256] Oxygen-loaded nanoparticles were able to enhance tumor oxygenation triggered by the NIR laser. injected into tumorbearing mice under hyperoxic breathing.…”

Section: Increase Of Tumor Oxygenation By Oxygen Deliverymentioning

confidence: 99%

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Emerging Nanotechnology and Advanced Materials for Cancer Radiation Therapy

et al. 2017

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Radiation therapy (RT) including external beam radiotherapy (EBRT) and internal radioisotope therapy (RIT) has been widely used for clinical cancer treatment. However, owing to the low radiation absorption of tumors, high doses of ionizing radiations are often needed during RT, leading to severe damages to normal tissues adjacent to tumors. Meanwhile, the RT efficacies are limited by different mechanisms, among which the tumor hypoxia-associated radiation resistance is a well-known one, as there exists hypoxia inside most solid tumors while oxygen is essential to enhance radiation-induced DNA damages. With the development in nanotechnology, there have been great interests in using nanomedicine strategies to enhance radiation responses of tumors. Nanomaterials containing high-Z elements to absorb radiation rays (e.g. X-ray) can act as radio-sensitizers to deposit radiation energy within tumors and promote treatment efficacy. Nanoscale carriers are able to deliver therapeutic radioisotopes into tumors for internal RIT, or chemotherapeutic drugs for synergistically combined chemo-radiotherapy. As uncovered in recent studies, the tumor microenvironment could be modulated by various nanomedicine approaches to overcome hypoxia-associated radiation resistance. Herein, the authors will summarize the applications of nanomedicine for RT cancer treatment, and pay particular attention to the latest development of 'advanced materials' for enhanced cancer RT.

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Section: Increase Of Tumor Oxygenation By Oxygen Deliverymentioning

confidence: 99%

Section: Increase Of Tumor Oxygenation By Oxygen Deliverymentioning

confidence: 99%

Emerging Nanotechnology and Advanced Materials for Cancer Radiation Therapy

et al. 2017

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“…The tumor microenvironment (TME), which is often featured with tumor hypoxia, acidic pH, and vascular abnormalities, [ 14–18 ] is an important factor that largely results in resistance of tumors to many conventional cancer therapies. In particular, for oxygen‐dependent therapy such as radiotherapy (RT) [ 19–21 ] and photodynamic therapy (PDT), [ 22–24 ] which oxygen is actively involved in the treatment process, the therapeutic effects are severely limited by the hypoxic tumor microenvironment and rapid consumption of oxygen. Therefore, designing TME‐modulating microswimmers with the capability of O 2 generation and improvement of the tumor oxygen may be of great interest for enhancing RT/PDT efficiency in hypoxic solid tumors.…”

Section: Introductionmentioning

confidence: 99%

Photosynthetic Biohybrid Nanoswimmers System to Alleviate Tumor Hypoxia for FL/PA/MR Imaging‐Guided Enhanced Radio‐Photodynamic Synergetic Therapy

Zhong

et al. 2020

Adv Funct Materials

125

108

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Biohybrid microswimmers have recently shown to be able to actively perform in targeted delivery and in vitro biomedical applications. However, more envisioned functionalities of the microswimmers aimed at in vivo treatments are still challenging. A photosynthetic biohybrid nanoswimmers system (PBNs), magnetic engineered bacteria-Spirulina platensis, is utilized for tumor-targeted imaging and therapy. The engineered PBNs is fabricated by superparamagnetic magnetite (Fe 3 O 4 NPs) via a dip-coating process, enabling its tumor targeting ability and magnetic resonance imaging property after intravenous injection. It is found that the PBNs can be used as oxygenerator for in situ O 2 generations in hypoxic solid tumors through photosynthesis, modulating the tumor microenvironment (TME), thus improving the effectiveness of radiotherapy (RT). Furthermore, the innate chlorophyll released from the RT-treated PBNs, as a photosensitizer, can produce cytotoxic reactive oxygen species under laser irradiation to achieve photodynamic therapy. Excellent tumor inhibition can be realized by the combined multimodal therapies. The PBNs also possesses capacities of chlorophyll-based fluorescence and photoacoustic imaging, which can monitor the tumor therapy and tumor TME environment. These intriguing properties of the PBNs provide a promising microrobotic platform for TME hypoxic modulation and cancer theranostic applications.

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“…Among all the parameters, oxygen levels play an essential role; tumor hypoxia has been shown to have a close relationship with the resistance of chemotherapy or radiotherapy [3]. For example, researchers are investigating new treating modalities called hypoxia modification therapy, using hyperbaric oxygen [4] or small-particle oxygen delivery systems [5] to improve tumor oxygen conditions and hence to help prevent tumor expansion and therapy resistance. In other examples like severe traumatic brain injury [6,7], great loss of blood may induce severe cerebral ischemia and harm the brain.…”

Section: Introductionmentioning

confidence: 99%

Photoacoustic Imaging in Oxygen Detection

Cao

Qiu

et al. 2017

Applied Sciences

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Oxygen level, including blood oxygen saturation (sO 2 ) and tissue oxygen partial pressure (pO 2 ), are crucial physiological parameters in life science. This paper reviews the importance of these two parameters and the detection methods for them, focusing on the application of photoacoustic imaging in this scenario. sO 2 is traditionally detected with optical spectra-based methods, and has recently been proven uniquely efficient by using photoacoustic methods. pO 2 , on the other hand, is typically detected by PET, MRI, or pure optical approaches, yet with limited spatial resolution, imaging frame rate, or penetration depth. Great potential has also been demonstrated by employing photoacoustic imaging to overcome the existing limitations of the aforementioned techniques.

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TaOx decorated perfluorocarbon nanodroplets as oxygen reservoirs to overcome tumor hypoxia and enhance cancer radiotherapy

Cited by 203 publications

References 35 publications

Emerging Nanotechnology and Advanced Materials for Cancer Radiation Therapy

Emerging Nanotechnology and Advanced Materials for Cancer Radiation Therapy

Photosynthetic Biohybrid Nanoswimmers System to Alleviate Tumor Hypoxia for FL/PA/MR Imaging‐Guided Enhanced Radio‐Photodynamic Synergetic Therapy

Photoacoustic Imaging in Oxygen Detection

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