Tanycytic ependymoma arising from the right lateral ventricle: A case report and review of the literature

Zhang, Sheng; Wang, Xingfu; Zhang, Zhenzhen; Chen, Yupeng

doi:10.1111/j.1440-1789.2007.00857.x

Cited by 18 publications

(13 citation statements)

References 26 publications

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“…Both myxopapillary tumors found in this cohort were extramedullary and located around the filum terminale, in keeping with previous reports of the typical location of this tumor subtype [8, 21, 34]. The case of the one patient with multiple grade II tanycytic tumors demonstrates the potential for aggressive behavior possessed by ependymomas, even in a histologic subtype reported to have a good prognosis [51]. …”

Section: Discussionsupporting

confidence: 89%

Spinal cord ependymoma: a review of the literature and case series of ten patients

et al. 2016

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Spinal cord ependymoma (SCE) is a rare tumor that is most commonly low-grade. Complete surgical resection has been established as first-line treatment and can be curative. However, SCEs tend to recur when complete tumor resection is not possible. Evidence supporting the use of adjuvant radiation and chemotherapy is not definitive. We review the most recent literature on SCE covering a comprehensive range of topics spanning the biology, presentation, clinical management, and outcomes. In addition, we present a case series of ten SCE patients with the goal of contributing to existing knowledge of this rare disease.

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Section: Discussionsupporting

confidence: 89%

Spinal cord ependymoma: a review of the literature and case series of ten patients

et al. 2016

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“…The prognosis of TE is associated with the patient age, tumor site and the extent of surgical resection. It has been reported that the 5-year and 10-year survival rates for TE are improved compared with those with other subtypes of ependymoma ( 33 , 39 ).…”

Section: Discussionmentioning

confidence: 99%

Tanycytic ependymoma of filum terminale: Clinical characteristics and surgical outcomes

et al. 2018

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Tanycytic ependymoma (TE), a rare subtype of ependymoma, was classified as grade II ependymoma by the World Health Organization in 2000 and 2007. Preoperative diagnosis of TE is challenging due to its similarities to schwannoma and astrocytoma; therefore, differentiation is required. The present study investigated the clinical, imaging and pathological characteristics of TE in the filum terminale. A retrospective analysis was conducted on the clinical, imaging, pathological and immunohistochemical characteristics of 8 patients with TE in the filum terminale and the relevant literature was reviewed. Of the 8 patients 7 were female and 1 was male, with an age range of 24–62 years old. The primary clinical symptom observed was lumbago, accompanied by lower limb pain and numbness. Magnetic resonance imaging predominantly identified isointensity on thoracic (T) 1-weighted images and iso- or hyperintense signal intensity on T2-weighted images, with homogeneous or inhomogeneous enhancement. All patients underwent resection of the tumor through a posterior median approach, and total resection was acighieved in 7 patients. During postoperative follow-up, all patients experienced improvement compared with their preoperative status, and were without tumor recurrence. The present study comprised the largest group of cases with TE in the filum terminale reported so far, to the best of our knowledge, which could foster a better understanding of this disease. Complete surgical resection of the tumor has the greatest effectiveness of any treatment for TE in the filum terminale. Postoperative histological examination, immunohistochemistry and electron microscopy for tumor specimens may assist in its diagnosis and differential diagnosis.

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“…In 1978, Friede and Pollak first described tanycytic ependymoma as a variant of ependymoma, being relatively common in the spinal cord. 11 To date, a number of tanycytic ependymomas have been described in both the cerebrum [12][13][14][15][16] and spinal cord. [17][18][19][20][21][22][23][24][25] Tanycytic ependymoma as the glial component of a cerebral ganglioglioma has also been described.…”

Section: Discussionmentioning

confidence: 99%

Cerebral and spinal cord tanycytic ependymomas in a young adult with a mutation in the NF2 gene

et al. 2014

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We studied one frontal lobe tumor and multiple spinal cord tumors (one in an extramedullary location) that had been resected from a 24-year-old man. The frontal lobe tumor was well demarcated and non-infiltrating, and consisted of eosinophilic, elongated fibrillary cells arranged in a fascicular pattern. A similar histology was reproduced in the spinal cord tumors, with additional areas showing standard features of ependymoma. Immunohistochemical and ultrastructural observations revealed that all the tumors were ependymal in nature with positivity for GFAP and epithelial membrane antigen and negativity for oligodendrocyte transcription factor 2, showing intra- and intercellular microrosettes, leading us to a diagnosis of tanycytic ependymoma for the frontal lobe tumor and tanycytic ependymoma with ordinary ependymomatous component for the spinal cord tumors. The spinal extramedullary tumor was a schwannoma. Importantly, a heterozygous truncating mutation in the NF2 gene was identified in the blood lymphocytes from the patient. It is known that multiple nervous system tumors can occur in neurofibromatosis type 2 (NF2), which is caused by mutation in the NF2 gene, and that occurrence of ependymoma, including the tanycytic variant, can be associated with this genetic condition. The present case provides further information about the clinicopathology of tanycytic ependymoma with details of the immunohistochemical, ultrastructural and genetic features.

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Tanycytic ependymoma arising from the right lateral ventricle: A case report and review of the literature

Cited by 18 publications

References 26 publications

Spinal cord ependymoma: a review of the literature and case series of ten patients

Spinal cord ependymoma: a review of the literature and case series of ten patients

Tanycytic ependymoma of filum terminale: Clinical characteristics and surgical outcomes

Cerebral and spinal cord tanycytic ependymomas in a young adult with a mutation in the NF2 gene

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