Tantalum-incorporated hydroxyapatite coating on titanium implants: its mechanical and in vitro osteogenic properties

Lü, Rui; Wang, Xing; He, Huixia; Lingling, E; Liu, Ying; Zhang, Guilan; Li, Chuanjie; Ning, Chengyun; Liu, Hongchen

doi:10.1007/s10856-019-6308-9

Cited by 45 publications

(31 citation statements)

References 37 publications

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“…In vivo experiments using a rabbit model showed that the Si-nHA coating significantly promoted new bone formation and osseointegration. The atmospheric plasma spraying was also used to deposit tantalum-doped HA on the Ti substrates by Lu et al [92]. The tantalum-doped HA coatings promoted cell adhesion, proliferation, and osteogenic differentiation of rat BMDSCs.…”

Section: Inorganic and Composite Coatingsmentioning

confidence: 99%

Osteoconductive and Osteoinductive Surface Modifications of Biomaterials for Bone Regeneration: A Concise Review

Kazimierczak

Przekora

2020

Coatings

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The main aim of bone tissue engineering is to fabricate highly biocompatible, osteoconductive and/or osteoinductive biomaterials for tissue regeneration. Bone implants should support bone growth at the implantation site via promotion of osteoblast adhesion, proliferation, and formation of bone extracellular matrix. Moreover, a very desired feature of biomaterials for clinical applications is their osteoinductivity, which means the ability of the material to induce osteogenic differentiation of mesenchymal stem cells toward bone-building cells (osteoblasts). Nevertheless, the development of completely biocompatible biomaterials with appropriate physicochemical and mechanical properties poses a great challenge for the researchers. Thus, the current trend in the engineering of biomaterials focuses on the surface modifications to improve biological properties of bone implants. This review presents the most recent findings concerning surface modifications of biomaterials to improve their osteoconductivity and osteoinductivity. The article describes two types of surface modifications: (1) Additive and (2) subtractive, indicating biological effects of the resultant surfaces in vitro and/or in vivo. The review article summarizes known additive modifications, such as plasma treatment, magnetron sputtering, and preparation of inorganic, organic, and composite coatings on the implants. It also presents some common subtractive processes applied for surface modifications of the biomaterials (i.e., acid etching, sand blasting, grit blasting, sand-blasted large-grit acid etched (SLA), anodizing, and laser methods). In summary, the article is an excellent compendium on the surface modifications and development of advanced osteoconductive and/or osteoinductive coatings on biomaterials for bone regeneration.

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Section: Inorganic and Composite Coatingsmentioning

confidence: 99%

Osteoconductive and Osteoinductive Surface Modifications of Biomaterials for Bone Regeneration: A Concise Review

Kazimierczak

Przekora

2020

Coatings

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“…In order to successfully install the implants, researchers make efforts to create bioactive coating materials on titanium surface using different techniques. 1,2 In these studies, favorable osteogenic, angiogenic and antibacterial capacities of coating materials have been widely explored. 3,4 However, many coating materials with excellent properties mentioned above could not achieve satisfactory results in the subsequent in vivo studies in terms of the regeneration of bones.…”

Section: Introductionmentioning

confidence: 99%

<p>Magnesium-doped Nanostructured Titanium Surface Modulates Macrophage-mediated Inflammatory Response for Ameliorative Osseointegration</p>

Qiao¹,

Yang²,

Shang³

et al. 2020

IJN

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Background: Next generation of coating materials on the surface of implants is designed with a paradigm shift from an inert material to an osteoimmunomodulatory material. Regulating immune response to biomedical implants through influencing the polarization of macrophage has been proven to be an effective strategy. Methods: Through anodization and hydrothermal treatment, magnesium ion incorporated TiO 2 nanotube array (MgN) coating was fabricated on the surface of titanium and it is hypothesized that it has osteoimmunomodulatory properties. To verify this assumption, systematic studies were carried out by in vitro and in vivo experiments. Results: Mg ion release behavior results showed that MgN coating was successfully fabricated on the surface of titanium using anodization and hydrothermal technology. Scanning electron microscopy (SEM) images showed the morphology of the MgN coating on the titanium. The expression of inflammation-related genes (IL-6, IL-1β, TNF-α) was downregulated in MgN group compared with TiO 2 nanotube (NT) and blank Ti groups, but anti-inflammatory genes (IL-10 and IL-1ra) were remarkably upregulated in the MgN group. The in vitro and in vivo results demonstrated that MgN coating influenced macrophage polarization toward the M2 phenotype compared with NT and blank-Ti groups, which enhanced osteogenic differentiation of rat bone mesenchymal stem cells rBMSCs in conditioned media (CM) generated by macrophages. Conclusion: MgN coating on the titanium endowed the surface with immune-regulatory features and exerted an advantageous effect on osteogenesis, thereby providing excellent strategies for the surface modification of biomedical implants.

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“…Porous tantalum has attracted much attention for its good biocompatibility and microstructure similar to cancellous bone[ 27 ]. In a recent study, Ta-incorporated HA coatings were developed by Lu et al[ 28 ] using the plasma spray technique on a titanium substrate. The result demonstrated that Ta-incorporated HA coating could promote initial adhesion and faster cell proliferation after incubation for 3 and 5 days, but it also promotes osteogenic differentiation of BMSCs compared to HA coatings.…”

Section: Biofunctionalization Of Orthopedic Implant With Bioactive Cementioning

confidence: 99%

Approaches to promoting bone marrow mesenchymal stem cell osteogenesis on orthopedic implant surface

Huo¹,

Yue²

2020

WJSC

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Bone marrow-derived mesenchymal stem cells (BMSCs) play a critical role in the osseointegration of bone and orthopedic implant. However, osseointegration between the Ti-based implants and the surrounding bone tissue must be improved due to titanium’s inherent defects. Surface modification stands out as a versatile technique to create instructive biomaterials that can actively direct stem cell fate. Here, we summarize the current approaches to promoting BMSC osteogenesis on the surface of titanium and its alloys. We will highlight the utilization of the unique properties of titanium and its alloys in promoting tissue regeneration, and discuss recent advances in understanding their role in regenerative medicine. We aim to provide a systematic and comprehensive review of approaches to promoting BMSC osteogenesis on the orthopedic implant surface.

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Tantalum-incorporated hydroxyapatite coating on titanium implants: its mechanical and in vitro osteogenic properties

Cited by 45 publications

References 37 publications

Osteoconductive and Osteoinductive Surface Modifications of Biomaterials for Bone Regeneration: A Concise Review

Osteoconductive and Osteoinductive Surface Modifications of Biomaterials for Bone Regeneration: A Concise Review

<p>Magnesium-doped Nanostructured Titanium Surface Modulates Macrophage-mediated Inflammatory Response for Ameliorative Osseointegration</p>

Approaches to promoting bone marrow mesenchymal stem cell osteogenesis on orthopedic implant surface

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