Tantalum implanted entangled porous titanium promotes surface osseointegration and bone ingrowth

Abstract

Porous Ti is considered to be an ideal graft material in orthopaedic and dental surgeries due to its similar spatial structures and mechanical properties to cancellous bone. In this work, to overcome the bioinertia of Ti, Ta-implanted entangled porous titanium (EPT) was constructed by plasma immersion ion implantation & deposition (PIII&D) method. Ca-implanted and unimplanted EPTs were investigated as control groups. Although no difference was found in surface topography and mechanical performances, both Ca- and Ta-implanted groups had better effects in promoting MG-63 cell viability, proliferation, differentiation, and mineralization than those of unimplanted group. The expression of osteogenic-related markers examined by qRT-PCR and western blotting was upregulated in Ca- and Ta-implanted groups. Moreover, Ta-implanted EPT group could reach a higher level of these effects than that of Ca-implanted group. Enhanced osseointegration of both Ca- and Ta-implanted EPT implants was demonstrated through in vivo experiments, including micro-CT evaluation, push-out test, sequential fluorescent labeling and histological observation. However, the Ta-implanted group possessed more stable and continuous osteogenic activity. Our results suggest that Ta-implanted EPT can be developed as one of the highly efficient graft material for bone reconstruction situations.

Microstructure and Corrosion Resistance of WC-Based Cermet/Fe-Based Amorphous Alloy Composite Coatings

“…Nevertheless, although the E corr of the WC-CoCr coating are comparable to the composite coating, the i corr of WC-CoCr is higher than that of the composite coating. Generally, the i corr is an important parameter to evaluate the kinetic of corrosion reactions, and besides the corrosion rate is proportional to the corrosion current density measured via polarization [35]. That means the lower i corr led to the lower corrosion rate [36].…”

“…SEM images from morphology and cross-section of (a-c) WC-CoCr powder, (d,e) mixture of WC-CoCr powder and Fe-based metallic glass powder with weight ratio of 65:35, and (f) Fe-based metallic glass particle. Label 1: WC-CoCr particles; Label 2: Fe-based metallic glass particles.…”

Significantly enhanced osteoblast response to nano-grained pure tantalum

“…, outstanding bone-like apatite forming capability in simulated body fluid (SBF), no cytotoxic ion release or dissolution in local, systemic and remote organs, as well as good osseointegration), superior strength, as well as anti-corrosion properties12345. Particularly, in vitro studies36 comparing the Ta implant and the common titanium (Ti) implant show that the bioactivity and cell-material interactions are significantly better in the case of Ta, further indicating Ta exhibits high promise for bone implant application.…”

Porous Titanium Associated with CaP Coating: In Vivo and In Vitro Osteogenic Performance

“…Among the reasons justifying these results, there is the fact that bioactive covering of porous surfaces allows rapid osseoconduction of the surrounding bone tissue as well as direct chemical linking between bone and implant 35 . Then, new surface has been continuously developed with the objective to be used in biomedical applications 9,13,22,29,30 . Porous scaffolds have attracted considerable attention for applications in bone tissue engineering because their interconnected pores can provide a favorable environment for bone in-growth and osseointegration 1,2,14,15,23 .…”

“…The biomimetic treatment is a method using supersaturated solution to form a calcium phosphate layer (e.g. hydroxyapatite), making the implant's surface osseoconductive 29,34,37 . In order to assess the precipitation of calcium and phosphate ions, the samples were observed with EDS analysis in which peaks of these ions had been observed on a diffractogram, a finding also reported elsewhere 34,37 .…”