Tantalum-coated polylactic acid fibrous membranes for guided bone regeneration

Hwang, Changha; Park, Suhyung; Kang, In-Ku; Kim, Hyoun‐Ee; Han, Cheol-Min

doi:10.1016/j.msec.2020.111112

Cited by 38 publications

(24 citation statements)

References 36 publications

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“…Among various methods for additive modifications of biomaterial surface, a magnetron sputtering deserves special attention as it enables deposition of many types of coating (ceramics and metals) onto substrate materials under vacuum condition [110,111]. For example, Hwang et al [112] fabricated tantalum-coated polylactic acid membranes using the magnetron sputtering technique. In vitro experiments exhibited that coated membranes promoted attachment, proliferation, and differentiation of MC3T3-E1 cells, whereas in vivo studies using a rabbit model showed that tantalum-coated polylactic acid membranes had better osteoconductivity than the uncoated ones.…”

Section: Magnetron Sputtering Modificationsmentioning

confidence: 99%

Osteoconductive and Osteoinductive Surface Modifications of Biomaterials for Bone Regeneration: A Concise Review

Kazimierczak

Przekora

2020

Coatings

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The main aim of bone tissue engineering is to fabricate highly biocompatible, osteoconductive and/or osteoinductive biomaterials for tissue regeneration. Bone implants should support bone growth at the implantation site via promotion of osteoblast adhesion, proliferation, and formation of bone extracellular matrix. Moreover, a very desired feature of biomaterials for clinical applications is their osteoinductivity, which means the ability of the material to induce osteogenic differentiation of mesenchymal stem cells toward bone-building cells (osteoblasts). Nevertheless, the development of completely biocompatible biomaterials with appropriate physicochemical and mechanical properties poses a great challenge for the researchers. Thus, the current trend in the engineering of biomaterials focuses on the surface modifications to improve biological properties of bone implants. This review presents the most recent findings concerning surface modifications of biomaterials to improve their osteoconductivity and osteoinductivity. The article describes two types of surface modifications: (1) Additive and (2) subtractive, indicating biological effects of the resultant surfaces in vitro and/or in vivo. The review article summarizes known additive modifications, such as plasma treatment, magnetron sputtering, and preparation of inorganic, organic, and composite coatings on the implants. It also presents some common subtractive processes applied for surface modifications of the biomaterials (i.e., acid etching, sand blasting, grit blasting, sand-blasted large-grit acid etched (SLA), anodizing, and laser methods). In summary, the article is an excellent compendium on the surface modifications and development of advanced osteoconductive and/or osteoinductive coatings on biomaterials for bone regeneration.

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Section: Magnetron Sputtering Modificationsmentioning

confidence: 99%

Osteoconductive and Osteoinductive Surface Modifications of Biomaterials for Bone Regeneration: A Concise Review

Kazimierczak

Przekora

2020

Coatings

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“…Currently, Ta is extensively applied as suture wires, cranioplasty plates and artificial joints as well as radiopaque markers, for surgical purposes [ 2 ]. Ta has historically been regarded as a bioinert material because of surface formation of a layer of passivating oxide with excellent chemical stability, which is highly unreactive and biocompatible in the body [ 3 ]. Early studies revealed that Ta had no obvious effect on osteoblast behaviors as compared with non-degradable plastics or metals in vitro cell culture, and thus did not stimulate inflammatory responses or induce giant cells in surrounding tissues in vivo animal experiments [ 4 ].…”

Section: Introductionmentioning

confidence: 99%

Implantable PEKK/tantalum microparticles composite with improved surface performances for regulating cell behaviors, promoting bone formation and osseointegration

Mei

Qian

et al. 2021

Bioactive Materials

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Polyetherketoneketone (PEKK) exhibits admirable biocompatibility and mechanical performances but bioinert while tantalum (Ta) possesses excellent osteogenesis and osseointegration but high elastic modulus and density, and processing is too difficult and expensive. In the present study, combining of the advantages of both PEKK and Ta, implantable composites of PEKK/Ta were fabricated by blending PEKK with Ta microparticles of 20 v% (PT20) and 40 v% (PT40) content. In comparison with PT20 and PEKK, the surface hydrophilicity, surface energy, roughness and proteins adsorption as well as mechanical performances of PT40 significantly increased because of the higher Ta particles content in PEKK. Furthermore, PT40 exhibited the mechanical performances (e.g., compressive strength and modulus of elasticity) close to the cortical bone of human. Compared with PT20 and PEKK, PT40 with higher Ta content remarkably enhanced the responses (including adhesion, proliferation and osteogenic differentiation) of MC3T3-E1 cells in vitro . Moreover, PT40 markedly improved bone formation as well as osseointegration in vivo . In short, incorporation of Ta microparticles into PEKK created implantable composites with improved surface performances, which played key roles in stimulating cell responses/bone formation as well as promoting osseointegration. PT40 might have great potential for bear-loading bone substitute.

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“…In the result; It has been observed that Ta-PLA coated membranes are mechanically more stable and most importantly their osteoconductive effects are more intense than GBR membranes containing PLA alone. In addition, when looking at collagen activity in the rest of the study, it was observed that Ta-coated PLA membranes had greater activity and contributed to bone regeneration [22]. When the study of Pyzik et al, which took into account the diameter of the pore in 2016, was examined, it was seen that PCL and PLA biopolymers prepared fibers with two different processing methods.…”

Section: Pla and Gel Based Gbr Membrane Case Studiesmentioning

confidence: 99%

A Review Polylactic Acid and Gelatin Biomaterial GBR (Guided Bone Regeneration) and Multilayer GBR Membranes

Kamacı¹,

Yucel²,

Köten³

et al. 2021

Journal of Polytechnic

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Tantalum-coated polylactic acid fibrous membranes for guided bone regeneration

Cited by 38 publications

References 36 publications

Osteoconductive and Osteoinductive Surface Modifications of Biomaterials for Bone Regeneration: A Concise Review

Osteoconductive and Osteoinductive Surface Modifications of Biomaterials for Bone Regeneration: A Concise Review

Implantable PEKK/tantalum microparticles composite with improved surface performances for regulating cell behaviors, promoting bone formation and osseointegration

A Review Polylactic Acid and Gelatin Biomaterial GBR (Guided Bone Regeneration) and Multilayer GBR Membranes

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