Tantalum coated on titanium dioxide nanotubes by plasma spraying enhances cytocompatibility for dental implants

Wang, Feifan; Li, Chuanjie; Zhang, Shuo; Liu, Hongchen

doi:10.1016/j.surfcoat.2019.125161

Cited by 36 publications

(27 citation statements)

References 47 publications

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“…It has been suggested that a natural thin layer of tantalum pentoxide existing on Ta surface might play a key role on its excellent biocompatibility, corrosion resistance, bioactivity as well as positive cell/tissue responses for bone on/in-growth [ 9 ]. Unfortunately, Ta is not as popular as Ti and its alloys in orthopedic implant manufactures, since the processing is too difficult and expensive [ 10 ]. Moreover, the significantly high elastic modulus and high density restricts the widespread acceptance of bulk Ta metal for implant applications [ 10 ].…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Implantable PEKK/tantalum microparticles composite with improved surface performances for regulating cell behaviors, promoting bone formation and osseointegration

Mei

Qian

et al. 2021

Bioactive Materials

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Polyetherketoneketone (PEKK) exhibits admirable biocompatibility and mechanical performances but bioinert while tantalum (Ta) possesses excellent osteogenesis and osseointegration but high elastic modulus and density, and processing is too difficult and expensive. In the present study, combining of the advantages of both PEKK and Ta, implantable composites of PEKK/Ta were fabricated by blending PEKK with Ta microparticles of 20 v% (PT20) and 40 v% (PT40) content. In comparison with PT20 and PEKK, the surface hydrophilicity, surface energy, roughness and proteins adsorption as well as mechanical performances of PT40 significantly increased because of the higher Ta particles content in PEKK. Furthermore, PT40 exhibited the mechanical performances (e.g., compressive strength and modulus of elasticity) close to the cortical bone of human. Compared with PT20 and PEKK, PT40 with higher Ta content remarkably enhanced the responses (including adhesion, proliferation and osteogenic differentiation) of MC3T3-E1 cells in vitro . Moreover, PT40 markedly improved bone formation as well as osseointegration in vivo . In short, incorporation of Ta microparticles into PEKK created implantable composites with improved surface performances, which played key roles in stimulating cell responses/bone formation as well as promoting osseointegration. PT40 might have great potential for bear-loading bone substitute.

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Section: Introductionmentioning

confidence: 99%

“…Unfortunately, Ta is not as popular as Ti and its alloys in orthopedic implant manufactures, since the processing is too difficult and expensive [ 10 ]. Moreover, the significantly high elastic modulus and high density restricts the widespread acceptance of bulk Ta metal for implant applications [ 10 ].…”

Section: Introductionmentioning

confidence: 99%

Implantable PEKK/tantalum microparticles composite with improved surface performances for regulating cell behaviors, promoting bone formation and osseointegration

Mei

Qian

et al. 2021

Bioactive Materials

View full text Add to dashboard Cite

show abstract

“…to produce functional coating in industry. Recently, the metal ion-substituted calcium phosphate coatings deposited by plasmaassisted techniques has been well-reviewed [43] and various cations, such as Sr, [44] Si, [45] Ce, [46] and Ta, [47] doped or co-doped coating via plasma-assisted methods for enhancing the biocompatibility of Ti have been reported.…”

Section: Physical Methodsmentioning

confidence: 99%

“…[191] However, the osseointegration at 6 weeks in rabbit bone shows no significant upregulation for Mg ion releasing coating, indicating minor effect at bone maturation stage. [192] Recently, Ta has been introduced to NTs [47] and Ta has been shown to promote bone regeneration in vitro and in vivo [193,194] and improve the corrosion resistance. [195] As a result, Ta-NTs coatings show enhanced adhesion, differentiation, mineralization, and osteogenic-related genes (BMP-2, ALP, OCN, and OPN) expression of MC3T3-E1 cells.…”

Section: Experts Opinionmentioning

confidence: 99%

Biofunctional Elements Incorporated Nano/Microstructured Coatings on Titanium Implants with Enhanced Osteogenic and Antibacterial Performance

Zhao

et al. 2020

Adv Healthcare Materials

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Bone fracture is prevalent among athletes and senior citizens and may require surgical insertion of bone implants. Titanium (Ti) and its alloys are widely used in orthopedics due to its high corrosion resistance, good biocompatibility, and modulus compatible with natural bone tissues. However, bone repair and regrowth are impeded by the insufficient intrinsic osteogenetic capability of Ti and Ti alloys and potential bacterial infection. The physicochemical properties of the materials and nano/microstructures on the implant surface are crucial for clinical success and loading with biofunctional elements such as Sr, Zn, Cu, Si, and Ag into nano/microstructured TiO 2 coating has been demonstrated to enhance bone repair/regeneration and bacterial resistance of Ti implants. In this review, recent advances in biofunctional element-incorporated nano/microstructured coatings on Ti and Ti alloy implants are described and the prospects and limitations are discussed.

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“…Different surface modification techniques for metal biomaterials have been proposed in recent years seeking a better biological response after their implantation 6 . In recent years, studies have demonstrated the efficiency of using TiO 2 nanotube-containing surfaces to increase cell proliferation.…”

Section: Introductionmentioning

confidence: 99%

Coated Surface on Ti-30Ta Alloy for Biomedical Application: Mechanical and in-vitro Characterization

et al. 2020

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Several studies have been carried out to develop new materials for biomedical applications. Material surfaces that present biomimetic morphology like nanotubes or nanofibers that provides nanoscale architectures have been shown to alter cell/biomaterial interactions. The coated surface biomaterial with biocompatible polymers and nanotubes of TiO 2 is an alternative to improve osseointegration. The anodization process was performed to obtain nanotubes of TiO 2 covering the Ti-30Ta alloy surface and the electrospinning process has been used for producing polymer fibers. Characterization techniques such as scanning electron microscopy (SEM-FEG), X-ray diffraction analysis (X-rays), thermogravimetric analysis (TGA), Differential Scanning Calorimetry (DSC) and contact angle were used for samples analyses. Adult human adipose-derived stem cells (ADSCs) were used to investigate the cellular response and S. aureus antimicrobial activity on these coated surfaces. The results indicated that both surface modification treatment showed a favorable micro-environment for cells growth and proliferation such as adhesion, viability and morphology which is a desire property for an implant. In addition, the antimicrobial activity study presented both materials with similar growth of S. aureus. So, it can conclude nanotubes and nanofibers can be used at biomedical field and both present similar cell evaluation and antimicrobial activity results.

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Tantalum coated on titanium dioxide nanotubes by plasma spraying enhances cytocompatibility for dental implants

Cited by 36 publications

References 47 publications

Implantable PEKK/tantalum microparticles composite with improved surface performances for regulating cell behaviors, promoting bone formation and osseointegration

Implantable PEKK/tantalum microparticles composite with improved surface performances for regulating cell behaviors, promoting bone formation and osseointegration

Biofunctional Elements Incorporated Nano/Microstructured Coatings on Titanium Implants with Enhanced Osteogenic and Antibacterial Performance

Coated Surface on Ti-30Ta Alloy for Biomedical Application: Mechanical and in-vitro Characterization

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