Tanshinones from Salvia miltiorrhiza inhibit Mycobacterium tuberculosis via disruption of the cell envelope surface and oxidative stress

Immunomodulatory Activity of Diterpenes over Innate Immunity and Cytokine Production in a Human Alveolar Epithelial Cell Line Infected with Mycobacterium tuberculosis

“…Carvacrol showed good antitubercular activity and synergism with rifampicin [ 36 ]. Tanshinones from Salvia miltiorrhiza inhibited M. tb via disruption of the cell envelope surface and oxidative stress [ 37 ]. Ursolic acid reduced M.tb-induced ntric oxide release in human alveolar A549 cells [ 38 ].…”

Recent research progress in the plant contribution to the management of tuberculosis

“…Importantly, the disorganization of the cell membrane leads to nonspecific secondary effects, like the dysfunction of the efflux pumps and disturbances in energy production affecting other cellular processes and leading to cell death (Gautam et al, 2023). Some of the effects observed in mycobacterial cells exposed to natural products are common (upregulation of the lipid molecules needed in the formation of the cell wall layers; activation of detoxification mechanisms and reactive species scavengers; changes in genes coding stress-responsive sigma factors) (Sawicki et al, 2022a;Sieniawska et al, 2020bSieniawska et al, , 2021a, while others specific for the stressing agents (disruption of bacterial cell envelope surface and release of cell components to the medium caused by tanshinones, or induction of N6-tuberculosinyladenosine formation in mycobacterial cells by garlic sulfides) (Figure 5) (Sawicki et al, 2023;Sieniawska et al, 2021b). These underline the antibacterial potential of natural products, which often target other, and different than antibiotics, cellular metabolic pathways.…”

“…Minimal inhibitory concentration (MIC) and minimal bactericidal concentration (MBC) values are two basic indicators ranking the activity of studied samples. Numerous research evaluated the antimycobacterial potential of local, endemic, or rare plant extracts, for example, from Iran (Dehestani et al, 2022), Uganda (Oloya et al, 2022), or Namibia (Raidron et al, 2022), or reviewed activity of various plant extracts (Chevtchouk Jurno et al, 2019;Gautam et al, 2023;Li et al, 2013;Sarkar et al, 2021) and endophytes from medicinal plants (Alvin et al, 2014), including potential synergistic interactions of plant products with antibiotics (Rahgozar et al, 2018;Sieniawska et al, 2018).…”

“…Common and specific mycobacterial metabolic pathways altered by natural products. Based on Sawicki et al (2022a, 2023); Sieniawska et al (2020b, 2021a, 2021b). …”

Abietane Quinone Diterpenes With Antituberculosis Activity Isolated From the Genus Salvia

“…and "in vivo" [5,6,10]. Species of the genus Salvia have been studied as a potential resource of quinone diterpenes with antimicrobial and antituberculosis activity [3,17].…”