Tanshinone IIA ameliorates the development of dermal fibrosis in systemic sclerosis
Ying Jiang,
Feifei Hu,
Ming Li
et al.
Abstract:ObjectivesWe previously revealed the role of tanshinone IIA (TAN IIA) on endothelial cells and the impact of TAN IIA on the endothelial‐to‐mesenchymal transition in systemic sclerosis (SSc). In this study, we sought to further determine whether TAN IIA can directly act on the skin fibroblasts of scleroderma and look into its underlying anti‐fibrotic mechanisms.MethodsBleomycin was used to establish the SSc mouse model. After TAN IIA treatment, dermal thickness, type I collagen and hydroxyproline content were m… Show more
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