Tanshinone IIA targeting cell signaling pathways: a plausible paradigm for cancer therapy

Alam, Syed Sahajada Mahafujul; Samanta, Arijit; Uddin, Faizan; Ali, Safdar; Hoque, Mehboob

doi:10.1007/s43440-023-00507-y

Cited by 6 publications

(2 citation statements)

References 120 publications

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“…Among these, the most interesting is tanshinone IIA, which demonstrated cardiovascular-protective [29,30] and renoprotective [31] activities, and antiviral activity [32]. It has also been recently investigated as a natural anticancer compound, due to its inhibitory effect on cancer with a certain regulatory effect on tumor angiogenesis [33][34][35]. Several recent papers have also addressed the large-scale production of Salvia spp.…”

Section: Introductionmentioning

confidence: 99%

An Update on Recent Studies Focusing on the Antioxidant Properties of Salvia Species

Iacopetta,

Ceramella,

Scumaci

et al. 2023

Antioxidants

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Nutrition has crucial effects and a significant role in disease prevention. Recently, nutraceuticals have attracted much attention in scientific research due to their pleiotropic effects and relatively non-toxic behavior. Among the biological effects displayed by plants belonging to the Lamiaceae family, such as antibacterial, anticancer, anti-inflammatory, and anticholinesterase, sage is well known for its antioxidant properties and is a rich source of numerous compounds that are biologically active, amongst them polyphenols, with more than 160 types identified. In this review we summarized some of the significant studies published in the last decade reporting the most employed extraction methods and the different assays that are useful for establishing the antioxidant properties of some sage species. Even though the scientific literature contains plenty of data regarding the antioxidant properties of many sage species, further studies are needed in order to gain a deeper understanding of the mechanism of action and the compounds responsible for their antioxidant activity. Finally, it should be taken into account that the data on the antioxidant properties of sage extracts are often difficult to compare with each other, since a series of variables in the extraction procedures, the type of assay used, and standardization may affect the final result.

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Section: Introductionmentioning

confidence: 99%

An Update on Recent Studies Focusing on the Antioxidant Properties of Salvia Species

Iacopetta,

Ceramella,

Scumaci

et al. 2023

Antioxidants

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show abstract

“…Among these, tanshinones are the major bioactive compounds responsible for S. miltiorrhiza's therapeutic effects, which find extensive application in the treatment of tumors [5], diabetes [6], and cardiovascular and cerebrovascular diseases [7]. Recent studies have further revealed the potential use of tanshinone IIA in cancer therapy [8]. Given the medicinal value of tanshinones, there is a growing demand for S. miltiorrhiza.…”

Section: Introductionmentioning

confidence: 99%

Miltiradiene Production by Cytoplasmic Metabolic Engineering in Nicotiana benthamiana

Ren,

Lin,

Huang

et al. 2023

Metabolites

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Plant natural products are important sources of innovative drugs, but the extraction and isolation of medicinal natural products from plants is challenging as these compounds have complex structures that are difficult to synthesize chemically. Therefore, utilizing heterologous expression systems to produce medicinal natural products in plants is a novel, environmentally friendly, and sustainable method. In this study, Nicotiana benthamiana was used as the plant platform to successfully produce miltiradiene, the key intermediate of tanshinones, which are the bioactive constituents of the Chinese medicinal plant Salvia miltiorrhiza. The yield of miltiradiene was increased through cytoplasmic engineering strategies combined with the enhancement of isoprenoid precursors. Additionally, we discovered that overexpressing SmHMGR alone accelerated apoptosis in tobacco leaves. Due to the richer membrane systems and cofactors in tobacco compared to yeast, tobacco is more conducive to the expression of plant enzymes. Therefore, this study lays the foundation for dissecting the tanshinone biosynthetic pathway in tobacco, which is essential for subsequent research. Additionally, it highlights the potential of N. benthamiana as an alternative platform for the production of natural products in plants.

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Expression of RIPK1 and FADD are associated with chemosensitivity and survival in head and heck squamous cell carcinoma via tanshinone IIA‐mediated modulation of the RIPK1‐FADD‐Caspase 8 complex

Shen,

Han,

Tan

et al. 2024

Molecular Carcinogenesis

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Tanshinone IIA (Tan IIA), a main active ingredient of salvia miltiorrhiza, has a wide range of antitumor effects, while its specific role and mechanism in head and neck squamous cell carcinomas (HNSCC) is not fully understood. Totally 59 primary HNSCC patients underwent two courses of induction chemotherapy before surgery. The association between expression of Fas‐Associated Death Domain (FADD) and receptor interacting protein kinase 1 (RIPK1) and chemotherapy resistance and survival were evaluated. The cell counting kit‐8 was used to detect the effect of Tan IIA on the activity of cisplatin in chemoresistant HNSCC cells through a series of in vitro experiments. The quantitative real‐time reverse‐transcription polymerase chain reaction, Western blot analysis and flow cytometry were used. FADD and RIPK1 expressions were differentially expressed in Chemosensitive and drug‐resistant patients. Furthermore, patients with tumors exhibiting high expression of FADD and RIPK1 had significantly greater risk for chemoresistance and mortality than patients with tumors that had low levels of these proteins. Moreover, Tan IIA reduced the expression of RIPK1 and FADD in HNSCC chemoresistant cell lines, which could increase the chemosensitivity of cisplatin and promote apoptosis. Overexpression of RIPK1 led to attenuation of therapeutic effects of Tan IIA, which were mainly realized through regulation of the RIPK1‐FADD‐Caspase 8 complex. This study is the first to demonstrate the clinical value and role of FADD and RIPK1 in the treatment of HNSCC. This work establishes the proapoptotic effects of Tan IIA and its potential to enhance chemosensitivity in HNSCC by modulating the RIPK1‐FADD‐Caspase 8 complex.

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Tanshinone IIA targeting cell signaling pathways: a plausible paradigm for cancer therapy

Cited by 6 publications

References 120 publications

An Update on Recent Studies Focusing on the Antioxidant Properties of Salvia Species

An Update on Recent Studies Focusing on the Antioxidant Properties of Salvia Species

Miltiradiene Production by Cytoplasmic Metabolic Engineering in Nicotiana benthamiana

Expression of RIPK1 and FADD are associated with chemosensitivity and survival in head and heck squamous cell carcinoma via tanshinone IIA‐mediated modulation of the RIPK1‐FADD‐Caspase 8 complex

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