Tanshinone IIA loaded bioactive nanoemulsion for alleviation of lipopolysaccharide induced acute lung injury via inhibition of endothelial glycocalyx shedding

El‐Moslemany, Riham M.; El-Kamel, Amal H.; Allam, Eman; Khalifa, Hoda; Hussein, Ahmed; Ashour, Asmaa A.

doi:10.1016/j.biopha.2022.113666

Cited by 14 publications

(8 citation statements)

References 77 publications

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“…Currently, research on EG in the ALI/ARDS field focuses mainly on two avenues: Firstly, it is broadly considered a potential therapeutic target. Several drug candidates have been evaluated for efficacy and safety against EG in animal models, such as Tanshinone IIA ( El-Moslemany et al, 2022 ), SERP 30 polysaccharide ( Feng et al, 2022 ), Crocin ( Zhang et al, 2020 ), and PCTR1(35). These candidates primarily target the expression of EG degradation products, like syndecan-1, or enzymes like HPA.…”

Section: Discussionmentioning

confidence: 99%

Global research progress of endothelial cells and ALI/ARDS: a bibliometric analysis

Zhou,

Long,

Chen

et al. 2024

Front. Physiol.

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BackgroundAcute lung injury (ALI) and acute respiratory distress syndrome (ARDS) are severe respiratory conditions with complex pathogenesis, in which endothelial cells (ECs) play a key role. Despite numerous studies on ALI/ARDS and ECs, a bibliometric analysis focusing on the field is lacking. This study aims to fill this gap by employing bibliometric techniques, offering an overarching perspective on the current research landscape, major contributors, and emerging trends within the field of ALI/ARDS and ECs.MethodsLeveraging the Web of Science Core Collection (WoSCC) database, we conducted a comprehensive search for literature relevant to ALI/ARDS and ECs. Utilizing Python, VOSviewer, and CiteSpace, we performed a bibliometric analysis on the corpus of publications within this field.ResultsThis study analyzed 972 articles from 978 research institutions across 40 countries or regions, with a total of 5,277 authors contributing. These papers have been published in 323 different journals, spanning 62 distinct research areas. The first articles in this field were published in 2011, and there has been a general upward trend in annual publications since. The United States, Germany, and China are the principal contributors, with Joe G. N. Garcia from the University of Arizona identified as the leading authority in this field. American Journal of Physiology-Lung Cellular and Molecular Physiology has the highest publication count, while Frontiers in Immunology has been increasingly focusing on this field in recent years. “Cell Biology” stands as the most prolific research area within the field. Finally, this study identifies endothelial glycocalyx, oxidative stress, pyroptosis, TLRs, NF-κB, and NLRP3 as key terms representing research hotspots and emerging frontiers in this field.ConclusionThis bibliometric analysis provides a comprehensive overview of the research landscape surrounding ALI/ARDS and ECs. It reveals an increasing academic focus on ALI/ARDS and ECs, particularly in the United States, Germany, and China. Our analysis also identifies several emerging trends and research hotspots, such as endothelial glycocalyx, oxidative stress, and pyroptosis, indicating directions for future research. The findings can guide scholars, clinicians, and policymakers in targeting research gaps and setting priorities to advance the field.

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Section: Discussionmentioning

confidence: 99%

Global research progress of endothelial cells and ALI/ARDS: a bibliometric analysis

Zhou,

Long,

Chen

et al. 2024

Front. Physiol.

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“…Sigma lipopolysaccharides (LPSs) were purchased from Sigma Aldrich, Cedex, France (Product name Lipopolysaccharides from Escherichia coli O111:B4, Product Number L2630, Sigma-Aldrich Chemie GmbH Eschenstrasse 5 D-82024 TAUFKIRCHEN company). The extracted LPS was obtained from E. coli ATCC 25922 bacteria according to El-Moslemany et al [ 19 ]. Nanocurcumin (NT-Cur-NPs; 4020) was purchased from Nanotech, Giza, Egypt for photo-electronics, Egypt.…”

Section: Methodsmentioning

confidence: 99%

“…Lipopolysaccharide was extracted by hot phenol–water method, as described previously, with some modifications [ 19 ]. In brief, bacterial suspensions E. coli ATCC 25922 (120 colony-forming units/mL) were centrifuged at 9000× g for 8 min.…”

Section: Methodsmentioning

confidence: 99%

The Neuroprotective and Antioxidant Effects of Nanocurcumin Oral Suspension against Lipopolysaccharide-Induced Cortical Neurotoxicity in Rats

et al. 2022

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Lipopolysaccharide (LPS) proved to be an important tool, not only in the induction of neuroinflammatory models, but also in demonstrating the behavioral and cognitive consequences of endotoxemia. Curcumin, in its native form, has proven to be a worthy candidate for further development as it protects the dopaminergic neurons against LPS-induced neurotoxicity. However, it remains hindered by its poor bioavailability. In this study we aim to explore the possible molecular mechanism of LPS-induced neurotoxicity and the possible protective effects of orally supplemented nanocurcumin. Thirty-six adult male Wistar rats weighing 170–175 g were divided into six groups and treated with single I.P. (intra-peritoneal) dose of LPS (sigma and extracted; separately) (5 mg/kg BW) plus daily oral nanocurcumin (15 mg/kg BW). The rats were followed for 7 days after the LPS injection and nanocurcumin supplementations daily via oral gavage. After scarification, the levels of neurotransmitters, antioxidants, and amyloidogenesis markers were assessed in brain tissues. Nanocurcumin showed adequate antioxidant and neuroprotective effects, rescuing the rats which had been injected intraperitoneally with LPS endotoxin.

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“…Degradation and shedding of the glycocalyx, the gel-like layer that lines the surface of the lumen of the vascular endothelium, has been implicated as an important mechanism in the pathogenesis of acute lung injury. 96 El-Moslemany et al 71 prepared a tanshinone IIA-loaded NEs formulation (TSIIA-NE) using ultrasound technology based on bioactive natural ingredients, rhamnolipid biosurfactant and TTO (as the oily phase). TSIIA-NE ameliorated LPS-induced pulmonary ventilatory dysfunction and pathological changes through antioxidant (up-regulation of superoxide dismutase, glutathione peroxidase, down-regulation of malondialdehyde), anti-inflammatory (up-regulation of IL-10, down-regulation of TNF-α and IL-17) and inhibition of glycocalyx degradation, as evidenced by a 1.4-fold and 1.9-fold increase in tidal volume and minute respiratory volume, respectively, a 32% decrease in the wet/dry lung weight ratio, and an improvement in arterial blood gas levels.…”

Section: Inhaled Nanoformulations Based On Natural Productsmentioning

confidence: 99%

“…TSIIA-NE ameliorated LPS-induced pulmonary ventilatory dysfunction and pathological changes through antioxidant (up-regulation of superoxide dismutase, glutathione peroxidase, down-regulation of malondialdehyde), anti-inflammatory (up-regulation of IL-10, down-regulation of TNF-α and IL-17) and inhibition of glycocalyx degradation, as evidenced by a 1.4-fold and 1.9-fold increase in tidal volume and minute respiratory volume, respectively, a 32% decrease in the wet/dry lung weight ratio, and an improvement in arterial blood gas levels. 71 Similarly, Arbain et al 72 prepared an O/W NE formulation loaded with quercetin using palm oil ester/ricinoleic acid as the oil phase. The formulation had an acceptable MMAD (3.09 ± 0.05 μm), high FPF (90.52 ± 0.10%), and percent inhaled (81.26 ± 1.28%), which met the physicochemical and nebulization characteristics required for deep lung delivery applications.…”

Section: Inhaled Nanoformulations Based On Natural Productsmentioning

confidence: 99%

Natural Products-Based Inhaled Formulations for Treating Pulmonary Diseases

Yong,

Shu,

Zhang

et al. 2024

IJN

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Given the unique physiological and pathological characteristics of the lung, the direct, inhalable route is more conducive to pulmonary drug delivery and disease control than traditional systemic drug delivery, significantly circumventing drug loss, off-target effects, systemic and organ toxicity, etc., and is widely regarded as the preferred regimen for pulmonary drug delivery. However, very few lung diseases are currently treated with the preferred inhaled formulations, such as asthma, chronic obstructive pulmonary disease and pulmonary hypertension. And there is a lack of appropriate inhaled formulations for other critical lung diseases, such as lung cancer and pulmonary fibrosis, due to the fact that the physicochemical properties of the drugs and their pharmacokinetic profiles do not match the physiology of the lung, and conventional inhalation devices are unable to deliver them to the specific parts of the lung. Phytochemicals of natural origin, due to their wide availability and clear safety profile, hold great promise for the preparation of inhalable formulations to improve the current dilemma in the treatment of lung diseases. In particular, the preparation of inhalable formulations based on nano- and microparticulate carriers for drug delivery to deep lung tissues, which overcome the shortcomings of conventional inhalation therapies while targeting the drug activity directly to a specific part of the lung, may be the best approach to change the current dilemma of lung disease treatment. In this review, we discuss recent advances in nano- and micron-carrier-based inhalation formulations for the delivery of natural products for the treatment of pulmonary diseases, which may represent an opportunity for practical clinical translation of natural products.

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Tanshinone IIA loaded bioactive nanoemulsion for alleviation of lipopolysaccharide induced acute lung injury via inhibition of endothelial glycocalyx shedding

Cited by 14 publications

References 77 publications

Global research progress of endothelial cells and ALI/ARDS: a bibliometric analysis

Global research progress of endothelial cells and ALI/ARDS: a bibliometric analysis

The Neuroprotective and Antioxidant Effects of Nanocurcumin Oral Suspension against Lipopolysaccharide-Induced Cortical Neurotoxicity in Rats

Natural Products-Based Inhaled Formulations for Treating Pulmonary Diseases

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