Tanshinone IIA inhibits atherosclerotic plaque formation by down-regulating MMP-2 and MMP-9 expression in rabbits fed a high-fat diet

Effects of tanshinone IIA, a major component of Salvia miltiorrhiza, on platelet aggregation in healthy newborn piglets

“…Studies have shown that MMP-2 increases and MMP-9 decreases platelet aggregation (Choi et al, 2008;Falcinelli et al, 2005;Lee et al, 2006). Our observation is somewhat similar to that reported previously that expressions of both MMP-2 and MMP-9 were inhibited in aorta of high fat diet rabbits after chronic treatment with tanshinone IIA (Fang et al, 2007). The lack of effect on MMP-2 and -9 activities in our present study could be due to different durations of STS treatment.…”

“…The interaction of platelets and endothelial cells, combining with the modulation of other cells, propagates further platelet aggregation to stop bleeding. Although the platelet function was not studied, a dose-related inhibition of both MMP-2 and MMP-9 expression in aorta of high fat diet rabbits was reported after chronic tanshinone IIA treatment for 2 months (Fang et al, 2007). More direct evidence has shown that incubating platelets with STS reduced the elevated P-selectin and ICAM expressions in thrombin-activated platelets (Jiang et al, 1998).…”

Anti-Inflammatory Effects of Tanshinone IIA on Atherosclerostic Vessels of Ovariectomized ApoE-/- Mice are Mediated by Estrogen Receptor Activation and Through the ERK Signaling Pathway

“…Tanshinone IIA(TanIIA), as the main lipophilic ingredient of Salvia miltiorrhiza, can significantly inhibit coronary artery contraction, improve coronary blood flow, exert anti-atherosclerotic actions, inhibit platelet aggregation and protect damaged endothelium [20,21,22,23,24,25,26]. Although there has been some research on the anti-inflammatory and anti-oxidative effects of TanIIA, these articles have not identificed a specific mechanism for these effects [21,27].…”

Direct purification of tanshinones from Salvia miltiorrhiza Bunge by high‐speed counter‐current chromatography without presaturation of the two‐phase solvent mixture

“…In the past years, a series of separation techniques, i.e. TLC, silica gel column chromatography, and preparative HPLC [14,[17][18][19], have been successfully applied for the purification of various compounds of S. miltiorrhiza Bunge. However, these traditional chromatographic methods are often time-consuming and suffer from sample loss because some minor samples are easily absorbed onto the solid support matrix.…”