Tanshinone II is a potent candidate for treatment of lipopolysaccharide-induced acute lung injury in rat model

Li, Ling; Zhang, Yonggang; Tan, Yufei; Zhao, Jingjing; Zhang, Hua‐Ru; Zhao, Bing

doi:10.3892/ol.2017.7581

Cited by 10 publications

(20 citation statements)

References 25 publications

(21 reference statements)

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“…Increasing reports demonstrate that tan IIA possesses therapeutic potential for numerous diseases with few side effects ( 30 , 32 – 34 , 36 , 38 ). Among the numerous biological activities of tan IIA, greater attention has been focused on increasing the sensitivity of tumor cells to chemotherapeutic drugs ( 45 , 46 ). Our previous studies demonstrate that the combination of tan IIA with ADM functions to inhibit the malignant biological behaviors of NSCLC cells in a synergistic way and was able to enhance the antitumor effect of ADM ( 38 ).…”

Section: Discussionmentioning

confidence: 99%

RETRACTED: Combination of Tanshinone IIA and Cisplatin Inhibits Esophageal Cancer by Downregulating NF-κB/COX-2/VEGF Pathway

et al. 2020

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Cisplatin (DDP) represents one of the common drugs used for esophageal squamous cell carcinoma (ESCC), but side effects associated with DDP and drug resistance lead to the failure of treatment. This study aimed to understand whether tanshinone IIA (tan IIA) and DDP could generate a synergistic antitumor effect on ESCC cells. Tan IIA and DDP are demonstrated to restrain ESCC cell proliferation in a time-and dose-dependent mode. Tan IIA and DDP at a ratio of 2:1 present a synergistic effect on ESCC cells. The combination suppresses cell migration and invasion abilities, arrests the cell cycle, and causes apoptosis in HK and K180 cells. Molecular docking indicates that tan IIA and DDP could be docked into active sites with the tested proteins. In all treated groups, the expression levels of E-cadherin, β-catenin, Bax, cleaved caspase-9, P21, P27, and c-Fos were upregulated, and the expression levels of fibronectin, vimentin, Bcl-2, cyclin D1, p-Akt, pERK , p-JNK, P38, COX-2, VEGF, IL-6, NF-κB, and c-Jun proteins were downregulated. Among these, the combination induced the most significant difference. Our results suggest that tan IIA could be a novel treatment for combination therapy for ESCC.

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Section: Discussionmentioning

confidence: 99%

RETRACTED: Combination of Tanshinone IIA and Cisplatin Inhibits Esophageal Cancer by Downregulating NF-κB/COX-2/VEGF Pathway

et al. 2020

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“…Tanshinone IIA is derived from the dried root or rhizome of Salviae miltiorrhizae Bge [ 84 ] and has anti‐inflammatory, [ 85 ] antioxidant [ 86 ] and neuroprotection activities. [ 87 ] Tanshinone IIA decreased the levels of ROS and MDA, increased the activities of SOD and GSH‐Px, reduced the levels of phosphorylate PKR‐like (p‐PERK), phosphorylate eukaryotic initiation factor 2 and binding immunoglobulin heavy chain protein (Bip) in Aβ‐treated HT22 cells.…”

Section: Quinones and Its Role In Admentioning

confidence: 99%

Quinones as preventive agents in Alzheimer’s diseases: focus on NLRP3 inflammasomes

Chen

Gao

Peng

et al. 2020

Journal of Pharmacy and Pharmacology

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Objectives Alzheimer's disease (AD) is a hidden neurological degenerative disease, which main clinical manifestations are cognitive dysfunction, memory impairment and mental disorders. Neuroinflammation is considered as a basic response of the central nervous system. NLRP3 (Nucleotide-binding domain leucine-rich repeat (NLR) and pyrin domain containing receptor 3) inflammasome is closely related to the occurrence of neuroinflammation. Activation of the NLRP3 inflammasome results in the release of cytokines, pore formation and ultimately pyroptosis, which has demonstrated one of the critical roles in AD pathogenesis. Inhibition of the activity of NLRP3 is one of the focuses of the research. Therefore, NLRP3 represents an attractive pharmacological target, and discovery compounds with good NLRP3 inhibitory activity are particularly important. Key findings Quinones have good neuroprotective effects and prevent AD, which may be related to their regulation of inflammatory response. The molecular docking was used to explore 12 quinones with AD prevention and treatment and NLRP3. Docking results showed that the combination of anthraquinones and NLRP3 were the best, and the top two chemical compounds were Purpurin and Rhein, which are the most promising NLRP3 inhibitors. Summary These quinones may provide the theoretical basis for finding lead compounds for novel neuroprotective agents. Quinones as NLRP3 inflammasomes inhibitors Da-bao Chen et al.

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“…Specific pathogen-free (SPF) male Wistar rats (2 months old, 180 ± 200 g) were purchased from Charles River Experimental Animal Co., Ltd. (Beijing, China) and raised in the Xiamen University Laboratory Animal Center (License number: SYXK (Min) 2018-0010). The animals were housed one week before the start of experiment under standard laboratory conditions at a stable temperature (22 ± 2 °C), humidity (50 ± 10%), and a 12/12 h light/dark cycle with food and water ad libitum [ 15 , 16 ]. All animal procedures were carried out at the Xiamen University Laboratory Animal Center and approved by the Ethics Committee of the First Affiliated Hospital of Xiamen University.…”

Section: Methodsmentioning

confidence: 99%

“…Previous studies have shown that SMI has a protective effect on ALI [14,15], but the mechanism remains unclear.…”

Section: Salvia Miltiorrhiza Injection (Smi) a Chinese Materiamentioning

confidence: 97%

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Salvia miltiorrhiza Injection Alleviates LPS‐Induced Acute Lung Injury by Adjusting the Balance of MMPs/TIMPs Ratio

Chen

Zhu

et al. 2020

Evidence-Based Complementary and Alternative Medicine

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Salvia miltiorrhiza injection (SMI) is a classical traditional Chinese medicine, which plays an active role in the treatment of many diseases such as promoting blood circulation, removing blood stasis, reducing inflammatory reaction, and improving acute lung injury (ALI). Previous studies have shown that matrix metalloproteinases (MMPs) and tissue inhibitors of metalloproteinases (TIMPs) are involved in the pathophysiological process of ALI. However, the relationship between SMI and MMPs/TIMPs remains unclear. In this study, Wistar rats were randomly divided into control group (NC), Salvia miltiorrhiza group (SM), lipopolysaccharide group (LPS), and Salvia miltiorrhiza treatment group (Tsm). The four groups were subdivided into four time points (2, 6, 12, and 24 hours), and specimens were collected after animal sacrifice at each time point. Serum TNF-α and IL-6 levels were detected by ELISA. The degree of lung injury was determined by lung tissue hematoxylin-eosin staining, lung wet/dry weight (W/D) ratio, and lung permeability index. The changes in lung MMPs/TIMPs protein and mRNA were detected by Western blot and real-time quantitative PCR. The results showed that rats injected with LPS experience acute lung injury, and the ratio of MMPs/TIMPs in lung tissues increased gradually with time. In the Tsm group, the ratio of MMPs/TIMPs decreased gradually, and likewise, the balance was gradually restored, while indicators related to lung injury were gradually declined. These data suggest that SMI alleviates LPS-induced acute lung injury; this protective effect may be related to regulation of the balance of MMPs/TIMPs ratio.

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Tanshinone II is a potent candidate for treatment of lipopolysaccharide-induced acute lung injury in rat model

Cited by 10 publications

References 25 publications

RETRACTED: Combination of Tanshinone IIA and Cisplatin Inhibits Esophageal Cancer by Downregulating NF-κB/COX-2/VEGF Pathway

RETRACTED: Combination of Tanshinone IIA and Cisplatin Inhibits Esophageal Cancer by Downregulating NF-κB/COX-2/VEGF Pathway

Quinones as preventive agents in Alzheimer’s diseases: focus on NLRP3 inflammasomes

Salvia miltiorrhiza Injection Alleviates LPS‐Induced Acute Lung Injury by Adjusting the Balance of MMPs/TIMPs Ratio

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