Tanshinone II A attenuates atherosclerotic calcification in rat model by inhibition of oxidative stress

Tanshinone IIA suppresses cholesterol accumulation in human macrophages: role of heme oxygenase-1

“…1 , we have shown that Tan attenuates atherosclerotic plaque formation in ApoE Ϫ / Ϫ mice. This is consistent with previous studies showing that Tan can inhibit atherogenesis ( 13,32 ). Macrophages play a critical role in the pathogenesis of atherosclerosis.…”

Oxytocin in The Prevention of Injury Due to Testicular Torsion/Detorsion in Rats

“…[34,35] ROS overexpression secondary to oxidative stress can negatively affect proteins, lipids, nucleic acids, carbohydrates, and other molecules and leads to cell membrane lipid peroxidation, protein denaturation, DNA damage, inflammation, cell proliferation, cell dysfunction, and apoptosis. [36] Thus, ROS may play a role in the pathogenesis of several diseases, such as atherosclerosis, [37] cancer, [38] diabetes mellitus, [39] infection, [40] central nervous system disorders, [41] and testicular torsion due to its involvement in lipid peroxidation. [38] In addition, negative effects of oxidative stress on the testes after the initiation of reperfusion have been reported in the testicular torsion induced rat model.…”

Hypolipidemic Effect of EthanolicExtract of Cyperus esculentumis in TritonWR-1339-Induced Hyperlipidemic Rats

“…This condition is an importance factor in the pathogenesis of coronary heart disease . 31, LDL carries cholesterol from the liver to the peripheral cells and arteries of the smooth muscle cells , a rise in LDL may cause deposition of cholesterol in the arteries and aorta .This contributes to the development of coronary heart disease 32 .Pretreatment with the ethanolictuber extract of Cyperus esculentumis at the doses of 300,400 and 600 mg/kgb.wt for a period of 29 days , lowered TG, TC, LDL and VLDL cholesterol in triton-induced hyperlipidemic rats. There was also an increased in HDL-cholesterol.…”