Tannins present in Cichorium intybus enhance glucose uptake and inhibit adipogenesis in 3T3-L1 adipocytes through PTP1B inhibition

Muthusamy, Velusamy Shanmuganathan; Anand, Suchith; Sangeetha, K. N.; Sujatha, S.; Balakrishnan, Arun; Lakshmi, Baddireddi Subhadra

doi:10.1016/j.cbi.2008.04.016

Cited by 113 publications

(71 citation statements)

References 33 publications

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“…Intriguingly, adipose PTP1B function could vary, depending on the adipose depot. PTP1B inhibition in 3T3-L1 adipocytes inhibits adipogenesis (53). In contrast, PTP1B deficiency in brown adipocytes promotes differentiation and adipogenesis (21,54).…”

Section: Discussionmentioning

confidence: 99%

Protein Tyrosine Phosphatase 1B Regulates Pyruvate Kinase M2 Tyrosine Phosphorylation

Bettaieb

Bakke

Nagata

et al. 2013

Journal of Biological Chemistry

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Background: Tyrosine phosphorylation of PKM2 inhibits its activity; however, the phosphatase(s) that regulates PKM2 phosphorylation remains unidentified. Results: PKM2 is a novel PTP1B substrate and PKM2 Tyr-105 and Tyr-148 are key sites that mediate the interaction. Conclusion: PTP1B regulates PKM2 tyrosine phosphorylation and activity in adipocytes. Significance: These findings provide new insights into the regulation of adipose PKM2 activity.

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Section: Discussionmentioning

confidence: 99%

Protein Tyrosine Phosphatase 1B Regulates Pyruvate Kinase M2 Tyrosine Phosphorylation

Bettaieb

Bakke

Nagata

et al. 2013

Journal of Biological Chemistry

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“…intybus is known to have antibacterial, digestive, bitter tonic, anti-inflammatory, diuretic, anti-hypercholestermic and laxative properties and does not cause any side effects (Saeed et al, 2015). Several authors have commended the medicinal importance of C. intybus due to the presence of a number of compounds such as inulin, sesquiterpene lactones, alkaloids, coumarins, chlorophyll pigments, flavonoids unsaturated sterols, vitamins, saponins and tannins (Muthusamy et al, 2008;Atta et al, 2010;Shad et al, 2013). This study was aimed at determining the effect of Cichorium intybus L. ethanol extract in comparison with vitamin C on the pathobiochemical indices of the liver and kidney of broilers reared under heat stress.…”

Section: The Effect Of Cichorium Intybus L Ethanol Extraction On Thementioning

confidence: 99%

The Effect of Cichorium Intybus L. Ethanol Extraction on the Pathological and Biomedical Indexes of the Liver and Kidney of Broilers Reared Under Heat Stress

Khodadadi

Mousavinasab

Khamesipour

et al. 2016

Rev. Bras. Cienc. Avic.

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The use of compounds with antioxidant properties as a source of phelanoeid compounds is highly recommendable in the poultry industry. Therefore, the effect of Cichorium intybus L. herb on pathobiochemical indexes of chicken under heat stress was studied. After exposure to heat stress (from day 21 to day 42 of growth), hydroalcoholic extraction was provided to 270 broiler chicks randomly divided into six groups and placed in two distinct poultry houses (heat stress and normal conditions). The three groups were recipient group of Cichorium intybus L.(1); recipient group of vitamin C (2) and control group (3). The birds in one of the houses were exposed to heat stress conditions (35 °C for 8 hours) for a time period between 22 to 42 days and the birds in the other house were reared under normal conditions (20-22°C) for the same time period. Blood samples collected from the birds showed that Cichorium intybus L. herb caused significant decrease in uric acid, Triglyceride, Alanine aminotransferase (ALT), total body clearance factors (CL-factors) and right ventricular failure index (RVF) and significant increase in K + under heat stress condition (p<0.05). Vitamin C caused significant decrease in uric acid, ALT, CL-factors and RVF index and significant increase in K+ and Na+ under heat stress condition (p<0.05). A significant decrease in cholesterol and triglyceride in recipient group of Cichorium intybus L was observed compared to the recipient group of vitamin C under heat stress condition (p<0.05). In a pathologic examination normal observations were in recipient group of Cichorium intybus L and recipient group of vitamin C compared to the control group. According to this study, use of Cichorium intybus L extract and vitamin C in chicken under heat stress induced improvement in liver, kidney activity and fat metabolism.

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“…Flavonoids are antioxidants that can protect the progressive destruction of pancreatic cells as a result of oxidative stress. Moreover, tannin is known to stimulate the glucose uptake by increasing the tissue sensitivity to insulin and prevent adipogenesis [12]. Both these effects help to increase the blood glucose levels.…”

Section: Resultsmentioning

confidence: 99%

Dietary Supplementation Effects of Noni (Morinda Citrifolia L.) Fruit Flour on Uric Acid and Blood Glucose of Quails (Coturnix Coturnix Japonica) Layer Phase

Adriani¹,

Yeane²

2017

KLS

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This study was aimed to determine the effect of noni fruit flour in ration on uric acid and blood glucose of quails layer phase. The research was conducted from March to May 2015 at Faculty of Animal Husbandry Universitas Padjadjaran. One hundred commercialquails aged 4 weeks were randomly allocated to four treatment groups as T1, T2, T3 and T4. The quails in the control group (T1) were given normal basal diet without the addition of noni fruit flour, while as other groups (T2, T3, T4) were supplemented with0.25, 0.50, and 0.75% noni fruit flour respectively with 25 quails per treatment group replicated five times with five quails per replicate in a Complete Randomized Design (CRD). The blood samples were randomly collected, five birds per replicate at the end experimental period (7 ℎ week) and analyzed for the estimation of uric acid and blood glucose. The results revealed that blood glucose was significantly (p > 0.05) increased in the groups fed noni at various levels when compared to the control. Further, a significantly (p < 0.05) proportional decreasing in blood uric acid levels was found with increase in the level of dietary noni fruit flour, with highest reduction in the group supplemented with 0.5% noni fruit flour (T3) compared to the control group and in the group suplemented with 0.25% (T2) for blood glucose.In conclusion, dietary inclusion of noni fruit flours had beneficial effect with regard to its ability in reducing the blood uric acid levels and increasing blood glucose of quails.

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Tannins present in Cichorium intybus enhance glucose uptake and inhibit adipogenesis in 3T3-L1 adipocytes through PTP1B inhibition

Cited by 113 publications

References 33 publications

Protein Tyrosine Phosphatase 1B Regulates Pyruvate Kinase M2 Tyrosine Phosphorylation

Protein Tyrosine Phosphatase 1B Regulates Pyruvate Kinase M2 Tyrosine Phosphorylation

The Effect of Cichorium Intybus L. Ethanol Extraction on the Pathological and Biomedical Indexes of the Liver and Kidney of Broilers Reared Under Heat Stress

Dietary Supplementation Effects of Noni (Morinda Citrifolia L.) Fruit Flour on Uric Acid and Blood Glucose of Quails (Coturnix Coturnix Japonica) Layer Phase

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