Tannins, Flavonol Sulfonates, and a Norlignan from Phyllanthus virgatus

Huang, Yun-Ju; Chen, Chien Chih; Hsu, Feng Lin; Chen, Chieh Fu

doi:10.1021/np970336v

Cited by 29 publications

(14 citation statements)

References 18 publications

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“…Optically active acetylenic norlignan virgatyne (22A, Fig. 26), a potential shikimate-derived natural product, was identified with tannins and flavonoid sulfonates from Phyllanthus virgatus [263].…”

Section: Biosynthesis Of Acetylenes Originating From the Shikimate Pamentioning

confidence: 99%

Biosynthesis and function of polyacetylenes and allied natural products

Minto

Blacklock

2008

Progress in Lipid Research

291

233

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Polyacetylenic natural products are a substantial class of often unstable compounds containing a unique carbon-carbon triple bond functionality, that are intriguing for their wide variety of biochemical and ecological functions, economic potential, and surprising mode of biosynthesis. Isotopic tracer experiments between 1960 and 1990 demonstrated that the majority of these compounds are derived from fatty acid and polyketide precursors. During the past decade, research into the metabolism of polyacetylenes has swiftly advanced, driven by the cloning of the first genes responsible for polyacetylene biosynthesis in plants, moss, fungi, and actinomycetes, and the initial characterization of the gene products.The current state of knowledge of the biochemistry and molecular genetics of polyacetylenic secondary metabolic pathways will be presented together with an up-to-date survey of new terrestrial and marine natural products, their known biological activities, and a discussion of their likely metabolic origins.

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Section: Biosynthesis Of Acetylenes Originating From the Shikimate Pamentioning

confidence: 99%

Biosynthesis and function of polyacetylenes and allied natural products

Minto

Blacklock

2008

Progress in Lipid Research

291

233

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“…Compounds 1 -20 were isolated from P. virgatus Forst. f. (Huang et al , 1996b;Huang et al , 1998b). Compounds 21 and 22 were isolated from P. tenellus Roxb.…”

Section: Compoundsmentioning

confidence: 99%

Screening of 25 compounds isolated from Phyllanthus species for anti‐human hepatitis B virus in vitro

Huang

et al. 2003

Phytotherapy Research

Self Cite

110

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Using an HBV-producing cell line and inhibition of the expression of the HBsAg and HBeAg as antiviral indicators, a study was conducted on 25 compounds isolated from four Phyllanthus (Euphorbiaceae) plants, including P. amarus Schum. & Thonn., P. multi florus Willd., P. tenellus Roxb. and P. virgatus Forst. f. It was found that niranthin (1), nirtetralin (3), hinokinin (5) and geraniin (13) at the non-cytotoxic concentration of 50 micro m, suppressed effectively both HBsAg and HBeAg expression, with the highest inhibition at 74.3%, 45.3%; 69.6%, 33.9%; 68.1%, 52.3%; 32.1%, 46.6%, respectively. Of these, niranthin (1) showed the best anti-HBsAg activity, while the most potent anti-HBeAg activity was observed with hinokinin (5).

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“…The traditional medicinal plant, Phyllanthus species, is common in tropical and subtropical regions of both hemispheres. The plant contains tannins and flavonoids, both active antioxidants 5 . Phyllanthus species have been widely used in Asian countries for the treatment of liver disorders 6, 7.…”

mentioning

confidence: 99%

Phyllanthus urinaria ameliorates the severity of nutritional steatohepatitis both in vitro and in vivo

Shen¹,

Shiyan

et al. 2007

Hepatology

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Hepatic oxidative stress plays a critical role in metabolic forms of steatohepatitis. Phyllanthus urinaria, an herbal medicine, has been reported to have potential antioxidant properties. We tested the effects of P. urinaria on nutritional steatohepatitis both in vitro and in vivo. Immortalized normal hepatocytes (AML-12) or primary hepatocytes were exposed to control, the methionine-and-choline-deficient (MCD) culture medium, in the presence or absence of P. urinaria for 24 hours. Hepatocyte triglyceride, release of alanine aminotransferase, lipoperoxides, and reactive oxygen species production were determined. Age-matched C57BL/6 and db/db mice were fed control or MCD diet for 10 days with or without P. urinaria. Hepatic steatosis, necroinflammation, triglycerides, and lipid peroxide levels were determined. Hepatic expression of inflammatory factors and lipid regulatory mediators were assayed. P. urinaria reduced steatosis and alanine aminotransferase (ALT) levels in culture of hepatocytes in a dose-dependent manner. Phyllanthus prevented MCD-induced hepatic fat accumulation and steatohepatitis in mice. This effect was associated with repressed levels of hepatic lipid peroxides, reduced expression of cytochrome P450-2E1, pro-inflammatory tumor necrosis factor alpha, interleukin-6, dampened activation of inflammatory c-Jun N-terminal kinase (JNK) and nuclear factor kappa B (NF-B), increased expression of lipolytic cytochrome P450 (Cyp4a10), and suppressed transcriptional activity of lipogenic CCAAT/enhancer binding protein ␤ (C/EBP␤). Hepatic acyl co-enzyme A oxidase that regulated hepatic beta-oxidation of fatty acid and other lipid regulators were not affected by P. urinaria. In conclusion, P. urinaria effectively alleviated the steatohepatitis induced by the MCD, probably through dampening oxidative stress, ameliorating inflammation, and decreasing lipid accumulation. (HEPATOLOGY 2008;47:473-483.)

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Tannins, Flavonol Sulfonates, and a Norlignan from Phyllanthus virgatus

Cited by 29 publications

References 18 publications

Biosynthesis and function of polyacetylenes and allied natural products

Biosynthesis and function of polyacetylenes and allied natural products

Screening of 25 compounds isolated from Phyllanthus species for anti‐human hepatitis B virus in vitro

Phyllanthus urinaria ameliorates the severity of nutritional steatohepatitis both in vitro and in vivo

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