Tanning from phototherapy for neonatal jaundice

Woody, Norman C.; Brodkey, Mark J.

doi:10.1016/s0022-3476(73)80439-1

Cited by 13 publications

(12 citation statements)

References 6 publications

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“…Melanocytes are present in the embryonic epidermis, and melanin synthesis in melanosomes begins already in the first trimester [11]. There are reports [19,20] of tanning of negroid and Asian newborns following phototherapy. This corresponds well with the increased melanin index found on the upper back and thigh of the phototherapy group in this study.…”

Section: Reflectance Parameter Changes During Phototherapymentioning

confidence: 99%

In vivo spectroscopy of jaundiced newborn skin reveals more than a bilirubin index

Randeberg¹,

Roll²,

Nilsen³

et al. 2005

Acta Paediatrica

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Section: Reflectance Parameter Changes During Phototherapymentioning

confidence: 99%

In vivo spectroscopy of jaundiced newborn skin reveals more than a bilirubin index

Randeberg¹,

Roll²,

Nilsen³

et al. 2005

Acta Paediatrica

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“…loose greenish stools, irritability, alteration of behavior (44), feeding difficulties, flea-bite rash, a tanning effect in Negro infants' skin (49), priapism, and the occasional case of the "bronze baby" (25). The long term consequences of phototherapy on intellectual and visual performance, recently reported by Drew et al (IS), are quite contrary to the findings of Teberg and Hodgman (47) and require further studies because of the many factors influencing the neuropsychologic development of neonate.…”

Section: Speculationmentioning

confidence: 99%

Influence of Phototherapy on the Serum Lipids of Jaundiced Newborn Infants

Hadjigeorgiou¹,

Triliouri²,

Trichopoulou³

et al. 1978

Pediatr Res

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SummaryThe serum nonesterified fatty acids (NEFA), triglycerides, total cholesterol, lipid P, lysolecithin, sphingomyelin, lecithin, and phosphatidylethanolamine were determined on 15 full term and 13 premature jaundiced infants, before and after 48 hr of phototherapy and compared to nonjaundiced matched control subjects.The cholesterol levels of the jaundiced full term newborns were significantly higher than those of the healthy control full term infants. Differences were also observed before and after phototherapy between the jaundiced full term and the jaundiced premature infants in the serum lipid P and sphingomyelin values, which were lower in the premature subjects. The serum triglycerides values of the jaundiced full term control infants were lower than those of the nonjaundiced newborns. A significant decrease of serum NEFA was observed after phototherapy in both the full term and premature groups of jaundiced infants.The differences noted in cholesterol and lipid P levels may be due to liver dysfunction because of the jaundice. The differences in NEFA levels before and after phototherapy can be caused by the photoosidative breaking up of the NEFA by the phototherapy, by the decreased absorption of NEFA, or the increased catabolism of lipids. The decreased synthesis of NEFA from ketone bodies and glucose, or the probability of binding of NEFA by the bilirubin during the phototherapy must also be considered. SpeculationThe higher serum cholesterol levels observed in the jaundiced infants could be due to hepatic damage (dysfunction or excretory impediment).The differences in NEFA levels before and after phototherapy can be caused by the photooxidative breaking up of the NEFA by the phototherapy, by the decreased absorption of NEFA, or by the increased catabolism of lipids. The decreased synthesis of NEFA from ketone bodies and glucose, or the probability of binding of NEFA by the bilirubin during phototherapy must also be considered.The effectiveness of phototherapy in the treatment of neonatal jaundice has been proved, but many questions about this form of treatment remain unanswered.Recognized short term complications of phototherapy (15) include growth retardation (SO), pyrexia, retinopathy (13). loose greenish stools, irritability, alteration of behavior (44), feeding difficulties, flea-bite rash, a tanning effect in Negro infants' skin (49), priapism, and the occasional case of the "bronze baby" (25). An i n vivo investigation into the influence of phototherapy on the levels of serum lipids of jaundiced newborns was undertaken by us.Review of the literature failed to reveal similar studies. MATERIALS AND METHODSThe serum NEFA, triglycerides, total cholesterol, lipid P, lysolecithin, sphingomyelin, lecithin, and phosphatidylethanolamine were determined on 15 full term and 13 premature jaundiced infants before and after 48 hr of phototherapy. The values after phototherapy were compared to 16 full term and 15 premature nonjaundiced controls subjects, matched for age and weight. The etiology of jaundice w...

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“…Melanocytes are present in the embryonic epidermis, and melanin synthesis in melanosomes begins already in the first trimester 11. There are reports 19,20 of tanning of negroid and Asian newborns following phototherapy. This corresponds well with the increased melanin index found on the upper back and thigh of the phototherapy group in this study.…”

Section: Discussionmentioning

confidence: 99%

In vivo spectroscopy of jaundiced newborn skin reveals more than a bilirubin index

et al. 2005

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Aim: The aims of this study were to improve the algorithms for calculating a transcutaneous bilirubin index (TcB), to follow the bilirubin concentrations during phototherapy and to evaluate possible changes in skin optical parameters such as pigmentation and erythema during phototherapy. Method: Reflectance measurements were performed on 51 jaundiced newborns, of which 10 were subjected to phototherapy. The measurements were collected with a diode array spectrophotometer with an integrating sphere accessory, and a TcB was calculated from the measured spectra using algorithms based on diffusion theory. The newborns' birthweights were 2000 g and their gestational age was 35.5 wk. They had no substantial illnesses, and no newborns were submitted to the study until their second day. Heel prick blood samples were analysed for total serum bilirubin (Sbr) by the diazo reaction method. Phototherapy equipment was either an overhead lamp or lightbed. Results: Measurements from the forehead gave the best correlation between TcB and Sbr (r=0.81, p<0.05). However, during phototherapy no significant correlation between TcB and Sbr was observed. A correlation (r=0.45, p<0.05) was found between phototherapy and melanin index obtained from the patients' back. Conclusions: Reflectance spectroscopy is useful in assessing bilirubin concentrations before phototherapy, and can also reveal changes in skin parameters such as pigmentation occurring as a result of phototherapy.

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Tanning from phototherapy for neonatal jaundice

Cited by 13 publications

References 6 publications

In vivo spectroscopy of jaundiced newborn skin reveals more than a bilirubin index

In vivo spectroscopy of jaundiced newborn skin reveals more than a bilirubin index

Influence of Phototherapy on the Serum Lipids of Jaundiced Newborn Infants

In vivo spectroscopy of jaundiced newborn skin reveals more than a bilirubin index

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