Tanning bed use, risk of melanoma and opportunity for prevention with sulforaphane

Su, L. Joseph; Stahr, Shelbie; Kadlubar, Susan; Chiang, Tung-Chin; Wong, Henry K.

doi:10.21037/tcr.2016.10.92

Cited by 1 publication

(2 citation statements)

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“…The most important risk factor for melanoma development is exposure to UV (ultraviolet) radiation by means of prolonged exposure to solar energy and/or frequent use of tanning beds. Other factors that increase the likelihood of disease development include innate predisposition and inheritable traits including fair skin, sun sensitivity and/or a large number of moles [296]. The aggressive nature of melanoma is associated with the accumulation of mutations that activate oncogenes (e.g., BRAF , NRAS ), while inactivating tumour suppressor genes (e.g., phosphatase and tensin homolog; PTEN) [297].…”

Section: Itcs As Anti-melanoma Agentsmentioning

confidence: 99%

“…The anti-carcinogenic effect of ITCs in malignant melanoma has been studied by utilizing both in vitro and in vivo models. In general, ITCs were found to be able to induce growth arrest and apoptosis [301] and also inhibit metastasis [302,303] through induction of various signal transduction pathways, generation of oxidative stress and disruption of mitochondrial function, all of which are important mediators of cell growth and proliferation [296].…”

Section: Itcs As Anti-melanoma Agentsmentioning

confidence: 99%

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The Role of Isothiocyanates as Cancer Chemo-Preventive, Chemo-Therapeutic and Anti-Melanoma Agents

et al. 2019

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Many studies have shown evidence in support of the beneficial effects of phytochemicals in preventing chronic diseases, including cancer. Among such phytochemicals, sulphur-containing compounds (e.g., isothiocyanates (ITCs)) have raised scientific interest by exerting unique chemo-preventive properties against cancer pathogenesis. ITCs are the major biologically active compounds capable of mediating the anticancer effect of cruciferous vegetables. Recently, many studies have shown that a higher intake of cruciferous vegetables is associated with reduced risk of developing various forms of cancers primarily due to a plurality of effects, including (i) metabolic activation and detoxification, (ii) inflammation, (iii) angiogenesis, (iv) metastasis and (v) regulation of the epigenetic machinery. In the context of human malignant melanoma, a number of studies suggest that ITCs can cause cell cycle growth arrest and also induce apoptosis in human malignant melanoma cells. On such basis, ITCs could serve as promising chemo-therapeutic agents that could be used in the clinical setting to potentiate the efficacy of existing therapies.

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Section: Itcs As Anti-melanoma Agentsmentioning

confidence: 99%