Tanning and Whitening Agents in Cosmetics

Chisvert, Alberto; Benedé, Juan L.; Salvador, Amparo

doi:10.1016/b978-0-444-63508-2.00006-0

Cited by 5 publications

(1 citation statement)

References 81 publications

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“…Various side-effects have been in fact ascribed to these active cosmetic ingredients. 22 Since ever skin and hair pigmentation have impacted considerably to human overall physical appearance and to social/sexual communication, so that melanin-browning reactions are today highlights for both cosmetic and pharmaceutical industries. Several bioactive molecules of natural or synthetic origin, as well as mixtures such as plant extracts, are exploited therapeutically for numerous skin disorders involving depigmentation, from the most trivial cases to the most devastating ones such as vitiligo.…”

Section: Introductionmentioning

confidence: 99%

Promelanogenic Effects by an Annurca Apple-Based Natural Formulation in Human Primary Melanocytes

Ferraro¹,

Piccolo²,

Pezzella³

et al. 2021

CCID

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Introduction Melanocytes are engaged in synthesis, transport, and release of pigments at the epidermal-melanin units in response to the finely regulated melanogenic pathway. A multifaceted combination of both intrinsic and extrinsic factors – from endocrine and paracrine dynamics to exogenous stimuli such as sunlight and xenobiotics – modulates expression and activity of proteins involved in pigmentation, including the rate-limiting enzyme tyrosinase. As well as playing critical physiological functions comprising skin photoprotection, melanins define hair and skin pigmentation which in turn have impacted considerably to human social communication since time immemorial. Additionally, numerous skin diseases based on pigmentation alterations can have serious public influence. While several melanogenesis inhibitors are already available, the number of melanin activators and tyrosinase stimulators as drug-like agents is still limited. Methods To explore the biological effects of an Annurca Apple-based nutraceutical preparation (AMS) on melanin production, experiments in cellular models of human skin were performed. Both primary cultures and co-cultures of epidermal melanocytes (HEMa) and follicular keratinocytes (HHFK) were used. Results We show that AMS, by now branded for its cutaneous beneficial effects, induces in total biocompatibility a significant promelanogenic effect in human primary melanocytes. In line, we found melanin cytosolic accumulation consistent with tyrosinase up-regulation. Conclusion Disposal of skin pigmenting agents would be attractive for the treatment of hypopigmentation disorders, to postpone skin photoaging or simply for fashion, so that discovery and development of melanogenesis stimulators, especially from natural sources, is nowadays a dynamic area of research.

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Section: Introductionmentioning

confidence: 99%

Promelanogenic Effects by an Annurca Apple-Based Natural Formulation in Human Primary Melanocytes

Ferraro¹,

Piccolo²,

Pezzella³

et al. 2021

CCID

View full text Add to dashboard Cite

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Tuning multiple enzyme-like activities by metal doping for identification and quantitation of antioxidants in cosmetics

Wu,

Su,

Shen

et al. 2024

Chemical Engineering Journal

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A Novel Characteristic of a Water-soluble UV-B Absorber, 2-Phenylbenzimidazole-5-sulfonic Acid: Suppression of Riboflavin-sensitized Singlet Oxygen Generation

Hisanaga,

Miyazawa,

Yagi

et al. 2023

Chemistry Letters

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2-Phenylbenzimidazole-5-sulfonic acid (PBSA) is a water-soluble UV-B absorber used in cosmetic sunscreens. Riboflavin (RF) is a water-soluble vitamin B2. RF is an efficient singlet oxygen photosensitizer. The effects of PBSA on RF-photosensitized singlet oxygen generation have been studied through measurements of transient absorption and time-resolved near-IR phosphorescence in phosphate buffer (pH 7.4). PBSA suppresses the RF-photosensitized singlet oxygen generation. The observed suppression can be ascribed to the quenching of the lowest excited triplet state of RF by PBSA.

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Tanning and Whitening Agents in Cosmetics

Cited by 5 publications

References 81 publications

Promelanogenic Effects by an Annurca Apple-Based Natural Formulation in Human Primary Melanocytes

Promelanogenic Effects by an Annurca Apple-Based Natural Formulation in Human Primary Melanocytes

Tuning multiple enzyme-like activities by metal doping for identification and quantitation of antioxidants in cosmetics

A Novel Characteristic of a Water-soluble UV-B Absorber, 2-Phenylbenzimidazole-5-sulfonic Acid: Suppression of Riboflavin-sensitized Singlet Oxygen Generation

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