Tannic acid-reinforced zwitterionic hydrogels with multi-functionalities for diabetic wound treatment

Abstract

Diabetic wounds remain one of the most prevalent hard-to-heal wounds in the clinic. The causative factors impeding the wound healing process include not only the elevated oxidative stress and bacterial...

Multifunctional hydrogel coatings with high antimicrobial loading efficiency and pH-responsive properties for urinary catheter applications

“…TA was added to the pre-gel solution, and formed a hybrid polySBMA-TA hydrogel coating due to the formation of hydrogen bonding and electrostatic interactions between zwitterionic groups and TA, as reported in our previous work. 23 Finally, different types of commonly used antimicrobial agents ( e.g. PVP-I, Cu, nitrofurazone) were loaded in the hydrogel coating using a one-step impregnation method.…”

Polyelectrolyte Hydrogels for Tissue Engineering and Regenerative Medicine

“…For example, Fang et al synthesized a tannic acid-reinforced poly(sulfobetaine methacrylate) (PTAPS) hydrogel via free radical polymerization with poly(ethylene glycol) diacrylate as the crosslinker. [78] The Reproduced with permission. [70] polyzwitterionic hydrogel possesses high mechanical properties and strong tissue adhesiveness and are suitable for treatment of diabetic or chronic wounds.…”

Recent Advances in Mechanical Reinforcement of Zwitterionic Hydrogels

“…The Young’s modulus of SRgel was shown as 2 MPa, similar to the Young’s modulus of artery indicating SRgel might be a potential artificial blood vessel candidate with reliable resistance to coagulation. Fang et al [ 115 ] used the hydrogen bond–dipole interaction between tannic acid and zwitterionic units to enhance zwitterionic SB 3 MA 2 hydrogel. The toughness of zwitterionic hydrogels increased significantly with the increase of tannic acid concentration.…”