Tannic acid-reinforced methacrylated chitosan/methacrylated silk fibroin hydrogels with multifunctionality for accelerating wound healing

He, Xi; Liu, Xuezhe; Jin, Yang; Du, Haibo; Chai, Ningwen; Zhou, Sha; Geng, Meng; Zhou, Xiaojun; He, Chuanglong

doi:10.1016/j.carbpol.2020.116689

Cited by 169 publications

(97 citation statements)

References 49 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Moreover, hydrogels can keep the wound moist, prevent microbial contamination and accelerate recovery, which make them ideal for use as wound dressings. 7,8 Hydrogels are porous three-dimensional crosslinked polymers that are obtained by the physical or chemical crosslinking of polymer chains. 9 In recent decades, hydrogels have been extensively researched and applied as wound dressings, drug delivery vehicles, implants, scaffolds and injectable polymer systems in the fields of tissue engineering, medicine and biomedical engineering, among others.…”

Section: Introductionmentioning

confidence: 99%

Silk fibroin/chitosan hydrogel with antibacterial, hemostatic and sustained drug‐release activities

Chen

Zhang

et al. 2021

Polymer International

View full text Add to dashboard Cite

Hydrogels are viable wound dressing materials that have gained increasing attention due to their specific physicochemical properties, biocompatibility and environmental responsiveness. In addition to keeping a wound area moist, hydrogels characterized by a porous network structure and regulated drug-release capacity promote the various phases of wound healing by effectively loading a drug and inducing anti-infection activity. In this study, we prepared a multifunctional hydrogel with antibacterial, hemostatic and sustained drug-release activities by chemically crosslinking silk fibroin (SF) and chitosan (CS) biomacromolecules. Results of characterization revealed that the synthesized hydrogel presents higher swelling and in vitro degradation rates under acidic conditions than in a neutral environment. Moreover, the three-dimensional network structure of the material and the transformation of the SF secondary structure resulted in enhanced compressive mechanical properties (maximum compressive stress of 50-130 kPa). In vitro studies of drug loading and release, antibacterial assay, cytotoxicity studies, and coagulation assay were performed. Results showed that the prepared hydrogel exhibits good bacteriostatic and hemostatic properties, and it is not toxic towards human skin fibroblasts. Therefore, the designed SF/CS hydrogel constitutes an excellent candidate material for wound dressings.

show abstract

Section: Introductionmentioning

confidence: 99%

Silk fibroin/chitosan hydrogel with antibacterial, hemostatic and sustained drug‐release activities

Chen

Zhang

et al. 2021

Polymer International

View full text Add to dashboard Cite

show abstract

“…By examining the wound area, clear variations and reductions in wound reduction were observed and measured. Wounds treated with PSA-Gel and PSA-Gel-TA hydrogels accelerated wound reduction as related with the control from day 7 after wound healing, in precise the results of PSA-Gel-TA hydrogels were considerably higher than the control and PSA-Gel hydrogels [38]. As shown, the wound with PSA-Gel-TA hydrogels exhibited excellent healing effects without obvious infection compared to the wound treated with blank PSA-Gel, which indicates the powerful antibacterial activity of the TA, rendering anti-infection feasible [39,40].…”

Section: In Vivo Wound Healing Studymentioning

confidence: 67%

“…After 14 days of wound treatment, the newly established extracellular matrix over scar tissue reported at a greater rate the aggregation of in ammatory cells, broblasts, and collagen bundles [41]. The in ammatory response was observed on day 7 to varying degrees in all groups; the development of granulation materials, with all the creation of new small blood vessels and hair follicles, in the wound treated with PSA-Gel-TA hydrogels [38,42].…”

Section: In Vivo Wound Healing Studymentioning

confidence: 98%

Preparation and characterization of a novel polysialic acid/gelatin composite hydrogels cross-linked by Tannic acid to improve healing and nursing care of cesarean section dressing

Zhang¹,

Chunjie²,

Wang³

et al. 2021

Preprint

View full text Add to dashboard Cite

The infections and delayed wound healing after cesarean delivery is one of the most complicated issues in surgical medicinal field. In the present investigation, designed novel polysialic acid loaded gelatin (PSA-Gel) composite hydrogels cross-linked by tannic acid (TA) has been developed and used as a facile wound dressing to improve cesarean wound healing ability with prevent bactericidal infections. The cross-linking effect was predominant when the TA content was lower, resulting in the formation of a cross-linked network. An effective TA cross-linking effect on the PSA-Gel hydrogel matrix was achieved when the amount of TA was around 15 wt %. The morphology of as-fabricated hydrogels was characterized using scanning electron microscopy (SEM) with an average pore sizes of PSA-Gel, PSA-Gel-TA-5%, PSA-Gel-TA-10%, and PSA-Gel-TA-15% hydrogels were 95.4 ± 12.6 µm, 120.4 ± 8.2 µm, 165.3 ± 21.6 µm, and 270.2 ± 32.5 µm, respectively. The effects of hydrogels on the swelling ratio, in vitro degradation, and mechanical properties were systemically evaluated. The TA cross-linked PSA-Gel hydrogels display strong antimicrobial behavior against gram-positive (Staphylococcus aureus) gram-negative (Escherichia coli) bacteria strains. Moreover, PSA-Gel-TA hydrogels also displayed favorable cytotoxicity toward L929 fibroblast cell lines. Finally, the therapeutic and wound healing potential of the PSA-Gel-TA hydrogels has been studied in vivo using the excision wound model in rats. The results indicate that the PSA-Gel-TA hydrogels have a greater and significant effect on wound closure and increased the wound healing rate compared with native PSA-Gel hydrogels and untreated control group. The findings suggest that PSA-Gel-TA hydrogels are promising dressing materials for the treatment of wound healing.

show abstract

“…Also, the degree of methacrylation was found to be tuned by adjusting the ratio of chitosan to methacrylic anhydride in the reaction (Figure S2, Supporting Information), which is consistent with the observation by Shen et al [24] As mentioned in the literature, chitosan has weak mechanical properties. [25] Thus, in the design of our wound dressing, as shown in Figure 1A,B, we introduced a 3D printable backing layer made from a rigid thermoplastic polymer. In our case, poly(caprolactone) (PCL) was used.…”

Section: Resultsmentioning

confidence: 99%

3D Printing Personalized, Photocrosslinkable Hydrogel Wound Dressings for the Treatment of Thermal Burns

Teoh

Mozhi

Sunil

et al. 2021

Adv Funct Materials

View full text Add to dashboard Cite

Considering the variations in burns depending on the circumstances that caused them, the need for personalized medicine and care for burn victims is vital to ensure that optimal treatment is provided. With the level of accuracy and customization that 3D printing brings as a technology, there is potential in its use to fabricate wound dressings that can provide better treatment for burn patients, provided that the material of choice has good printability and can be customized while facilitating wound healing. In this study, the versatility of chitosan methacrylate as said material to be used to fabricate customizable wound dressings via 3D printing is investigated. Synthesized chitosan methacrylate is evaluated to be printable, biodegradable, and biocompatible during wound healing. Various drugs relevant to the treatment of burns are then loaded and different multimaterial wound dressing designs containing different dosages are fabricated via 3D printing. The incorporation of said drugs does not significantly affect the printability of chitosan methacrylate, and the incorporation of antimicrobial agents significantly improves its antimicrobial capabilities. Through in vivo models, these variations in wound dressing designs have good wound healing properties and do not cause any adverse effects in the process.

show abstract

Tannic acid-reinforced methacrylated chitosan/methacrylated silk fibroin hydrogels with multifunctionality for accelerating wound healing

Cited by 169 publications

References 49 publications

Silk fibroin/chitosan hydrogel with antibacterial, hemostatic and sustained drug‐release activities

Silk fibroin/chitosan hydrogel with antibacterial, hemostatic and sustained drug‐release activities

Preparation and characterization of a novel polysialic acid/gelatin composite hydrogels cross-linked by Tannic acid to improve healing and nursing care of cesarean section dressing

3D Printing Personalized, Photocrosslinkable Hydrogel Wound Dressings for the Treatment of Thermal Burns

Contact Info

Product

Resources

About