Tannic acid elicits selective antitumoral activity in vitro and inhibits cancer cell growth in a preclinical model of glioblastoma multiforme

Bona, Natália Pontes; Pedra, Nathália Stark; Azambuja, Juliana H.; Soares, Mayara Sandrielly Pereira; Spohr, Luíza; Gelsleichter, Nicolly Espindola; Meine, Bernardo de Moraes; Sekine, F; Mendonça, Lorenço Torres; Oliveira, Francine Hehn de; Braganhol, Elizandra; Spanevello, Rosélia Maria; Silveira, Elita Ferreira da; Stefanello, Francieli Moro

doi:10.1007/s11011-019-00519-9

Cited by 30 publications

(10 citation statements)

References 41 publications

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“…This step may be hindered by TBMS1, as it downregulates MET. Superoxide dismutase (SOD) and catalase (CAT) downregulate ROS levels and could therefore also inhibit Akt activation when upregulated by tannic acid and berberine [ 39 , 58 ]. Finally, Akt activity can be reduced through the downregulation of PI3K.…”

Section: Mechanistic Effects Of Natural Compounds On Glioblastomamentioning

confidence: 99%

“…Trials on orthotopic animal models therefore constitute an initial step in assessing natural compounds’ clinical viability. Of the reviewed substances, astaxanthin, adonixanthin, crocetin, eucalyptal A, tannic acid, rutin, and quercetin exerted appreciable anti-GBM effects in murine orthotopic models [ 32 , 34 , 35 , 39 , 63 ]. As such, these compounds are promising with regard to in situ bioavailability and BBB permeability.…”

Section: Challenges and Considerations In The Use Of Natural Substances For Gbm Treatmentmentioning

confidence: 99%

“…Recent preclinical studies reveal varying levels of GBM selectivity between compounds and cell lines. Tannic acid did not alter the viability of normal rat astrocytes at concentrations up to 75 µM, while diosmin at up to 150 µM remained minimally cytotoxic toward human astrocytes [ 39 , 46 ]. In contrast, withaferin A, cedrol, and rupesin E exhibited dose-dependent cytotoxicity; these compounds inhibited only GBM cells at lower concentrations, but both GBM cells and astrocytes at higher concentrations.…”

Section: Challenges and Considerations In The Use Of Natural Substances For Gbm Treatmentmentioning

confidence: 99%

“…The carotenoids astaxanthin and crocetin meet the same criteria [ 34 , 35 ]. Tannic acid is also promising, as it exhibits efficacy in orthotopic models as well as selectivity for GBM cells and minimal toxicity to astrocytes [ 39 ].…”

Section: Implications For Lifestyle Medicinementioning

confidence: 99%

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Natural Compounds in Glioblastoma Therapy: Preclinical Insights, Mechanistic Pathways, and Outlook

Zhai

Siddiqui

Abdellatif

et al. 2021

Cancers

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Glioblastoma (GBM) is an aggressive, often fatal astrocyte-derived tumor of the central nervous system. Conventional medical and surgical interventions have greatly improved survival rates; however, tumor heterogeneity, invasiveness, and chemotherapeutic resistance continue to pose clinical challenges. As such, dietary natural substances—an integral component of the lifestyle medicine approach to chronic diseases—are examined as potential chemotherapeutic agents. These heterogenous substances exert anti-GBM effects by upregulating apoptosis and autophagy, inducing cell cycle arrest, interfering with tumor metabolism, and inhibiting proliferation, neuroinflammation, chemoresistance, angiogenesis, and metastasis. Although these beneficial effects are promising, natural substances’ efficacy in GBM is constrained by their bioavailability and blood–brain barrier permeability; various chemical formulations are proposed to improve their pharmacological properties. Many of the reviewed substances are available as over-the-counter dietary supplements, underscoring their viability as lifestyle interventions. However, clinical trials remain necessary to substantiate the in vitro and in vivo properties of natural substances.

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Section: Mechanistic Effects Of Natural Compounds On Glioblastomamentioning

confidence: 99%

Section: Challenges and Considerations In The Use Of Natural Substances For Gbm Treatmentmentioning

confidence: 99%

Section: Challenges and Considerations In The Use Of Natural Substances For Gbm Treatmentmentioning

confidence: 99%

Section: Implications For Lifestyle Medicinementioning

confidence: 99%

See 2 more Smart Citations

Natural Compounds in Glioblastoma Therapy: Preclinical Insights, Mechanistic Pathways, and Outlook

Zhai

Siddiqui

Abdellatif

et al. 2021

Cancers

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“…Induction of apoptosis resulted mostly from increased level of caspase-3 [41]. In contrast, in the report of Bona et al [42], the increased sub-G1 population of C6 cells, as a result of the treatment with TA in comparable concentrations, was described, along with the induction of apoptosis and necrosis. Moreover, TA reduced the formation and size of colonies, as well as cell migration and adhesion.…”

Section: Glioma Cancer Cellsmentioning

confidence: 73%

Tannic Acid: Specific Form of Tannins in Cancer Chemoprevention and Therapy-Old and New Applications

et al. 2020

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Purpose of Review This short review is aimed at providing an updated and comprehensive report on tannic acid biological activities and molecular mechanisms of action most important for cancer prevention and adjuvant therapy. Recent Findings Tannic acid (TA), a mixture of digallic acid esters of glucose, is a common ingredient of many foods. The early studies of its anti-mutagenic and anti-tumorigenic activity were mostly demonstrated in the mouse skin model. This activity has been explained by its ability to inhibit carcinogens activation, as well as antioxidant and anti-inflammatory properties. Recently, the cell cycle arrest, apoptosis induction, reduced rate of proliferation, and cell migration and adhesion of several cancer cell lines as a result of TA treatment were described. The underlining mechanisms include modulation of signaling pathways such as EGFR/Jak2/STATs, or inhibition of PKM2 glycolytic enzyme. Moreover, epithelial-to-mesenchymal transition prevention and decrease of cancer stem cells formation by TAwere also reported. Besides, TAwas found to be potent chemosensitizer overcoming multidrug resistance. Eventually, its specific physicochemical features were found useful for generation of drug-loaded nanoparticles. Summary TA was shown to be a very versatile molecule with possible application not only in cancer prophylaxis, as was initially thought, but also in adjuvant cancer therapy. The latter may refer to chemosensitization and its application as a part of drug delivery systems. More studies are required to better explore this subject. In addition, the effect of TA on normal cells and its bioavailability have to better characterized.

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Quaternary nanoparticles enable sustained release of bortezomib for hepatocellular carcinoma

Zhang

Zhou

et al. 2022

Hepatology

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Background and Aims: Hepatocellular carcinoma (HCC) represents the third leading cause of cancer-related mortality in the world. Over the past two decades, there has been minimal improvement in therapies as well as clinical outcomes for patients with Barcelona Clinic Liver Cancer (BCLC)-B.These patients are treated with local interventions, including transarterial chemoembolization. Current methodologies only allow sustained intratumoral release measured in hours. Methodologies to allow sustained local release of the drug cargo over days to weeks are acutely needed. We hypothesize that tumor response as well as outcomes of patients with BCLC-B can be improved through utilization of a highly cytotoxic agent delivered with a sustained release platform.Approach and Results: High-throughput drug screening across 40 HCC patient-derived organoids identified bortezomib (BTZ) as a highly cytotoxic small molecule for HCC. We designed and manufactured sustained release BTZ nanoparticles (BTZ-NP) using a flash nanocomplexation/nanoprecipitation process. We quantified the release profile and tested the anti-tumoral effects in vivo. The BTZ-NP formulation demonstrated a sustained release of BTZ of 30 days. This BTZ-NP formulation was highly effective in controlling tumor size and improved survival in vivo in three animal models of HCC, including when delivered via the hepatic artery, as we envision its delivery in patients. In addition, the BTZ-NP formulation was superior to treatment with doxorubicin-drug eluting beads. Conclusions:The BTZ-NP formulation provides a potent and safe treatment of HCC via a localized delivery approach. These results warrant additional preclinical studies to advance this technology to human clinical trials.

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Tannic acid elicits selective antitumoral activity in vitro and inhibits cancer cell growth in a preclinical model of glioblastoma multiforme

Cited by 30 publications

References 41 publications

Natural Compounds in Glioblastoma Therapy: Preclinical Insights, Mechanistic Pathways, and Outlook

Natural Compounds in Glioblastoma Therapy: Preclinical Insights, Mechanistic Pathways, and Outlook

Tannic Acid: Specific Form of Tannins in Cancer Chemoprevention and Therapy-Old and New Applications

Quaternary nanoparticles enable sustained release of bortezomib for hepatocellular carcinoma

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