Tannic acid decorated poly(methacrylic acid) micro and nanoparticles with controllable tannic acid release and antioxidant properties

Şahiner, Nurettin; Sengel, Sultan Butun

doi:10.1016/j.colsurfa.2016.08.014

Cited by 16 publications

(16 citation statements)

References 41 publications

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“…The conjugation reactions are usually esterifications or acylations, mediated by coupling agents like dicyclohexyl carbodiimide, 1‐ethyl‐3‐(3‐dimethylaminopropyl) carbodiimide or N‐hydroxysuccinimide esters . For example, tannic acid has been covalently attached to poly(metacrylic acid) to form tannic acid‐decorated nanoparticles, the antioxidant activity of which is higher than that of the antioxidant alone …”

Section: Nanovectors For Antioxidant Targeting and Deliverymentioning

confidence: 99%

Antioxidants and Nanotechnology: Promises and Limits of Potentially Disruptive Approaches in the Treatment of Central Nervous System Diseases

Martinelli

Pucci

Battaglini

et al. 2019

Adv Healthcare Materials

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Many central nervous system (CNS) diseases are still incurable and only symptomatic treatments are available. Oxidative stress is suggested to be a common hallmark, being able to cause and exacerbate the neuronal cell dysfunctions at the basis of these pathologies, such as mitochondrial impairments, accumulation of misfolded proteins, cell membrane damages, and apoptosis induction. Several antioxidant compounds are tested as potential countermeasures for CNS disorders, but their efficacy is often hindered by the loss of antioxidant properties due to enzymatic degradation, low bioavailability, poor water solubility, and insufficient blood–brain barrier crossing efficiency. To overcome the limitations of antioxidant molecules, exploitation of nanostructures, either for their delivery or with inherent antioxidant properties, is proposed. In this review, after a brief discussion concerning the role of the blood–brain barrier in the CNS and the involvement of oxidative stress in some neurodegenerative diseases, the most interesting research concerning the use of nano‐antioxidants is introduced and discussed, focusing on the synthesis procedures, functionalization strategies, in vitro and in vivo tests, and on recent clinical trials.

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Section: Nanovectors For Antioxidant Targeting and Deliverymentioning

confidence: 99%

Antioxidants and Nanotechnology: Promises and Limits of Potentially Disruptive Approaches in the Treatment of Central Nervous System Diseases

Martinelli

Pucci

Battaglini

et al. 2019

Adv Healthcare Materials

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“…G/TAx matrices were prepared based on the protocol described in for 24 h at room temperature. After three rinsing steps, the matrices are lyophilized (6).…”

Section: G/tax Matrix Characterizationmentioning

confidence: 99%

“…2020;2:e200002. https://doi.org/10.20900/pf20200002 poly(methacrylic acid) microparticles releasing TA for more than 40 h [6].…”

Section: Introductionmentioning

confidence: 99%

Use of Gelatin as Tannic Acid Carrier for Its Sustained Local Delivery

2020

Pharm Front

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Background: Polyphenols are macromolecules that play a pivotal role in plant protection against external aggression from microorganisms or radiations. Their antimicrobial properties have raised interest in the medical community for several years now. Among them, tannic acid is one of the cheapest polyphenols extracted from plants. However, its broad use is impeded because it is unstable, with rapid hydrolysis leading to byproducts such as epigallocatechin with less activity. In this work, we developed a porous material to deliver locally tannic acid.Methods: The preparation of this matrix relied on the interaction between gelatin and tannic acid in an aqueous medium. Structure properties of the developed matrix were investigated through rheology measurement and by scanning electron microscopy (SEM). Tannic acid quantity and release over time were measured. Antimicrobial activity was tested in vitro on E. coli and S. aureus.Results: The presence of two tannic acid populations, one free to diffuse across the scaffold and the second stabilized by gelatin with a more structural activity, was demonstrated. We showed that the formulation is possible above a molar ratio of 1:15 (gelatin:tannic acid). Gelatin was used here as a carrier for the tannic acid. Tannic acid content could be modulated depending on its initial concentration during the preparation.Tannic acid was released from these matrices over a period of four days at a concentration that was above the minimum inhibitory concentration (MIC). Antimicrobial activity was confirmed on E. coli and S. aureus. The porous material could be conserved by lyophilization without loss of activity. Its handiness is good enough to consider its use as a wound dressing. Conclusions:We demonstrate herein an easy and cost-effective protocol to locally deliver tannic acid. Open Access

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“…These materials are of great interest since they find several applications as separation membranes 5 , sensors 6 , adsorbents, medical and pharmaceutical drug delivery systems, as well as in other various nanotechnology fields [7][8][9] .…”

Section: Introductionmentioning

confidence: 99%

“…For instance, poly(methacrylicacid)/tannic acid 7 and N-succinyl chitosan-poly(methacrylic acid) 10 have been tested for drug release; poly(methacrylic acid)-g-cellulose/bentonite 11 and poly(N-vinylpyrrolidone-methacrylic acid) 12 hydrogels are used as cationic dye uptake. Whereas hydrogels of (chitosan, itaconic and methacrylic acid) 13 for heavy metal adsorption.…”

Section: Introductionmentioning

confidence: 99%

Synthesis, Characterization and Swelling study of Poly (Methacrylic acid-co-Maleic acid) Hydrogels

Belkadi¹,

Bendaikha²,

Lebsir³

et al. 2018

Orient. J. Chem

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A series of poly (methacrylic acid-Co-maleic acid), P(MAA-MA), hydrogels have been prepared by free radical polymerization in aqueous medium using different amount of maleic acid (MA) (0-5 wt.%), initiated by potassium persulfate (KPS) in the presence of N,N'-methylenebisacrylamide (MBA) as a crosslinking agent. Fourier transform infrared spectroscopy (FTIR), thermogravimetric analysis (TGA) and scanning electron microscope (SEM) techniques were used to characterize the prepared hydrogels. Their swelling behaviours were investigated according to the maleic acid content and pH of solution. Kinetic swelling of hydrogels was studied too. The results showed that the swelling ratios increase with increasing the maleic acid content. Kinetic studies showed good fitting to pseudo-second order equation. The prepared hydrogels obeyed non-Fickian water diffusion.

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Tannic acid decorated poly(methacrylic acid) micro and nanoparticles with controllable tannic acid release and antioxidant properties

Cited by 16 publications

References 41 publications

Antioxidants and Nanotechnology: Promises and Limits of Potentially Disruptive Approaches in the Treatment of Central Nervous System Diseases

Antioxidants and Nanotechnology: Promises and Limits of Potentially Disruptive Approaches in the Treatment of Central Nervous System Diseases

Use of Gelatin as Tannic Acid Carrier for Its Sustained Local Delivery

Synthesis, Characterization and Swelling study of Poly (Methacrylic acid-co-Maleic acid) Hydrogels

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