Tannic Acid Attenuates Peripheral and Brain Changes in a Preclinical Rat Model of Glioblastoma by Modulating Oxidative Stress and Purinergic Signaling

Bona, Natália Pontes; Soares, Mayara Sandrielly Pereira; Pedra, Nathália Stark; Spohr, Luíza; Santos, Francieli da Silva dos; Farias, Alana Seixas de; Alvez, Fernando Lopez; Meine, Bernardo de Moraes; Luduvico, Karina Pereira; Spanevello, Rosélia Maria; Stefanello, Francieli Moro

doi:10.1007/s11064-022-03547-7

Cited by 7 publications

(4 citation statements)

References 53 publications

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“…Tannic acid was administered orally 30 min prior to the ROT injection for 28 days. The dose of TA (50 mg/kg) was selected based on a previous study [ 60 ]. The experimental animals were randomly assigned into four experimental groups: Group 1, assigned as the naive control group; Group 2, assigned as the ROT control group; Group 3, assigned as the TA control group; Group 4, assigned as the ROT + TA group.…”

Section: Methodsmentioning

confidence: 99%

Tannic Acid Mitigates Rotenone-Induced Dopaminergic Neurodegeneration by Inhibiting Inflammation, Oxidative Stress, Apoptosis, and Glutamate Toxicity in Rats

Azimullah,

Meeran,

Ayoob

et al. 2023

IJMS

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Parkinson’s disease (PD), a movement disorder, is a neurodegenerative disease characterized by the degeneration of dopaminergic neurons in the substantia nigra pars compacta (SNpc) region of the brain. The etiopathogenesis of PD involves increased oxidative stress, augmented inflammation, impaired autophagy, accumulation of α-synuclein, and α-Glutamate neurotoxicity. The treatment of PD is limited and there is a lack of agents to prevent the disease/delay its progression and inhibit the onset of pathogenic events. Many agents of natural and synthetic origin have been investigated employing experimental models of PD, mimicking human PD. In the present study, we assessed the effect of tannic acid (TA) in a rodent model of PD induced by rotenone (ROT), a pesticide and an environmental toxin of natural origin reported to cause PD in agricultural workers and farmers. Rotenone (2.5 mg/kg/day, i.p.) was administered for 28 days, and TA (50 mg/kg, orally) was administered 30 min before ROT injections. The study results showed an increase in oxidative stress, as evidenced by the depletion of endogenous antioxidants and enhanced formation of lipid peroxidation products, along with the onset of inflammation following a rise in inflammatory mediators and proinflammatory cytokines. ROT injections have also augmented apoptosis, impaired autophagy, promoted synaptic loss, and perturbed α-Glutamate hyperpolarization in rats. ROT injections also induced the loss of dopaminergic neurons subsequent to the activation of microglia and astrocytes. However, TA treatment was observed to reduce lipid peroxidation, prevent loss of endogenous antioxidants, and inhibit the release and synthesis of proinflammatory cytokines, in addition to the favorable modulation of apoptosis and autophagic pathways. Treatment with TA also attenuated the activation of microglia and astrocytes along with preservation of dopaminergic neurons following reduced loss of dopaminergic neurodegeneration and inhibition of synaptic loss and α-Glutamate cytotoxicity. The effects of TA in ROT-induced PD were attributed to the antioxidant, anti-inflammatory, antiapoptotic, and neurogenesis properties. Based on the present study findings, it can be concluded that TA may be a promising novel therapeutic candidate for pharmaceutical as well as nutraceutical development owing to its neuroprotective properties in PD. Further regulatory toxicology and translational studies are suggested for future clinical usage in PD.

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Section: Methodsmentioning

confidence: 99%

Tannic Acid Mitigates Rotenone-Induced Dopaminergic Neurodegeneration by Inhibiting Inflammation, Oxidative Stress, Apoptosis, and Glutamate Toxicity in Rats

Azimullah,

Meeran,

Ayoob

et al. 2023

IJMS

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“…Thus, Bona et al [89] tested the antitumor effect of this substance in rats with glioblastoma and the interference with ectonucleotidases, in which tannic acid was able to increase the hydrolysis of ATP and AMP nucleotides and decrease the Purinergic system modulation in cutaneous melanoma by means of natural compounds. The literature has been evidenced in the adjuvant therapeutic perspective that several compounds derived from nature can act against carcinogenesis and cutaneous melanoma.…”

Section: Natural Compounds With Antitumor Effect and Their Purinergic...mentioning

confidence: 99%

“…When comparing the levels of ectonucleotidases in control mice, those with glioblastoma and those with glioblastoma treated with tannic acid, it was observed that the substance was able to maintain levels similar to those in mice without the disease. Bearing in mind that the purinergic system is able to modulate tumor progression, the aggressiveness of this type of cancer, and the results obtained in the study in question, tannic acid can be considered a promising agent for the treatment of cancer [89].…”

Section: Natural Compounds With Antitumor Effect and Their Purinergic...mentioning

confidence: 99%

The Potential of the Purinergic System as a Therapeutic Target of Natural Compounds in Cutaneous Melanoma

Silva¹,

Mânica²,

Moreno³

et al. 2022

Purinergic System

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Cutaneous melanoma is an aggressive and difficult-to-treat disease that has rapidly grown worldwide. The pharmacotherapy available in so many cases results in low response and undesirable side effects, which impair the life quality of those affected. Several studies have been shown that the purinergic system is involved in cancer context, such as in cutaneous melanoma. With technological advances, several bioactive compounds from nature are studied and presented as promising adjuvant therapies against cancer, as phenolic compounds and related action by purinergic system modulations. Thus, phenolic compounds such as rosmarinic acid, resveratrol, tannic acid, as well as vitamin D may be promising substances in a therapeutic perspective to treat cutaneous melanoma via purinergic system pathway. More research needs to be done to open up new horizons in the treatment of melanoma by the purinergic signaling.

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“…[36,37] TA in nature can help plants resist the invasion of marine bacteria (such as TA in mangrove bark) [38] , and commercial TA also has good antibacterial properties. [37] Previous reports have also shown that the TA structure contains numerous catechol, pyrogallol, and aromatic ring structures, which not only endow it with strong ROS scavenging ability, [39,40] but also enable TA to bind to various surfaces through various interactions, such as hydrogen bonds, ion bonds ππ/cation-π interactions. [36] The above evidence suggests that using TA to remove ROS may affect the surface adhesion of fouling organisms.…”

Section: Introductionmentioning

confidence: 99%

An Eco-Friendly Antifouling Coating Based on Tannic Acid

Wang,

Zhao,

Wang

et al. 2023

Preprint

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Marine fouling has caused serious economic losses, and exploring multiple eco-friendly antifouling strategies has a positive significance. As a natural polyphenolic antioxidant, Tannic acid (TA) has a wide range of sources and biosafety, excellent antibacterial properties and its special chemical structure makes it easy to bind to the surface, which may provide inspiration for the development of antifouling materials. In this paper, a TA-based antifouling coating was designed and prepared. A stable intermediate transition layer was formed by co-deposited 3,4-dihydroxy phenyl-L-alanine (DOPA) and polyethyleneimine (PEI) on the surface of polyvinyl chloride (PVC), and then TA molecules were grafted on that surface to prepare a TA functionalized (PVC/(PDA/PEI)-TA) coating. The effect of the coating on the adhesion of marine bacteria and benthic diatoms was investigated. Then, the effect of TA on the adhesion behavior of mussels on the coating surface was studied. The results indicated that the coating had good antifouling performance. Marine bacteria and benthic diatoms had a low adhesion rate on the coating surface and were prone to the detachment under water flow erosion. The TA on the coating surface affected the adhesion behavior of mussels. Mussels did not like TA coating and only secreted a small amount of adhesive plaques on the surface. Moreover, the adhesion force between the plaques and the substrate was low. This study may provide new solutions to marine biofouling.

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Tannic Acid Attenuates Peripheral and Brain Changes in a Preclinical Rat Model of Glioblastoma by Modulating Oxidative Stress and Purinergic Signaling

Cited by 7 publications

References 53 publications

Tannic Acid Mitigates Rotenone-Induced Dopaminergic Neurodegeneration by Inhibiting Inflammation, Oxidative Stress, Apoptosis, and Glutamate Toxicity in Rats

Tannic Acid Mitigates Rotenone-Induced Dopaminergic Neurodegeneration by Inhibiting Inflammation, Oxidative Stress, Apoptosis, and Glutamate Toxicity in Rats

The Potential of the Purinergic System as a Therapeutic Target of Natural Compounds in Cutaneous Melanoma

An Eco-Friendly Antifouling Coating Based on Tannic Acid

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